Search results for "Helium"
showing 10 items of 1689 documents
Extreme ameloblastoma of the mandible with hypoproteinemia. A case report and review of clinicopathological features
2011
Ameloblastoma is a tumor of odontogenic epithelium. It has an intermediate malignant potential, thus positioning it in a gray zone between benign and malignant neoplasms. Invasive ameloblastomas of excessive size are rarely confronted. Although these ameloblastomas are benign, they are life threatening. Many have eventuated in death due to airway obstruction, starvation from restriction of feeding, and complications of hypoproteinemia. These tumors cause significant expansion of skin and lips [tissue expanders]. Due to its metabolic demands, a tumor of enormous size will have numerous feeding vessels. Patients with extreme ameloblastomas are usually from rural areas of developing countries …
On the numerical assessment of the thermo-mechanical performances of the DEMO Helium-Cooled Pebble Bed breeding blanket module
2014
Within the framework of the European DEMO Breeder Blanket Programme, a research campaign has been launched by University of Palermo, ENEA-Brasimone and Karlsruhe Institute of Technology to theoretically investigate the thermo-mechanical behavior of the Helium-Cooled Pebble Bed (HCPB) breeding blanket module of the DEMO1 blanket vertical segment, under normal operation and over-pressurization loading scenarios. The research campaign has been carried out following a theoretical-computational approach based on the finite element method (FEM) and adopting a qualified commercial FEM code. A realistic 3D FEM model of the HCPB blanket module central poloidal-radial region has been developed, inclu…
Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved.
1998
Abstract —Estrogens have been found to reduce the incidence of cardiovascular disease that has been ascribed in part to an increased expression and/or activity of the vasoprotective endothelial NO synthase (NOS III). Some reports have shown that the level of expression of this constitutive enzyme can be upregulated by estrogens. The current study investigates the molecular mechanism of the NOS III upregulation in human endothelial EA.hy 926 cells. Incubation of EA.hy 926 cells with 17β-estradiol or the more stable 17α-ethinyl estradiol enhanced NOS III mRNA and protein expression up to 1.8-fold, without changing the stability of the NOS III mRNA. There was no enhancement of NOS III mRNA af…
Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide syntha…
2002
Background— Generation of the second-messenger molecule ceramide by stimulated sphingomyelinase activity has been implicated in the inflammatory processes contributing to the pathogenesis of atherosclerosis. However, reports of stimulatory effects of ceramide on endothelial NO production in animal models suggest antiatherosclerotic effects of the molecule. Therefore, we investigated long-term effects of ceramide on NO generation in human endothelial cells. Methods and Results— In human umbilical vein endothelial cells (HUVECs) and in HUVEC-derived EA.hy 926 endothelial cells, C6-ceramide ( N -hexanoyl- d -erythro-sphingosine) reduced the generation of bioactive NO (RFL-6 reporter-cell assa…
Histamine Upregulates Gene Expression of Endothelial Nitric Oxide Synthase in Human Vascular Endothelial Cells
2003
Background— Histamine has a short-term, transient, stimulating effect on endothelial nitric oxide synthase (eNOS) activity; however, long-term effects on eNOS have not been described yet. In addition, the vascular effect of histamine seems to depend critically on eNOS functionality. Therefore, we studied the effects of histamine on eNOS gene expression and function. Methods and Results— In human umbilical vein endothelial cells (HUVECs) and HUVEC-derived EA.hy 926 cells, histamine upregulated eNOS mRNA (RNase protection assay) and protein (electron microscopic immunocytochemistry) expression. The upregulation of eNOS could be prevented by mepyramine, a selective antagonist at the H 1 recep…
Ionizing radiation-induced E-selectin gene expression and tumor cell adhesion is inhibited by lovastatin and all-trans retinoic acid
2004
E-selectin mediated tumor cell adhesion plays an important role in metastasis. Here we show that ionizing radiation (IR) induces E-selectin gene and protein expression in human endothelial cells at therapeutically relevant dose level. E-selectin expression is accompanied by an increase in the adhesion of human colon carcinoma cells to primary human umbilical vein endothelial cells (HUVEC). The HMG-CoA reductase inhibitor lovastatin impairs IR-stimulated E-selectin expression as analyzed at the level of the protein, mRNA and promoter. Inactivation of Rho GTPases either by use of Clostridium difficile toxin A or by co-expression of dominant-negative Rho blocked IR-induced E-selectin gene indu…
Single cell RNAseq provides a molecular and cellular cartography of changes to the human endometrium through the menstrual cycle
2018
SummaryIn a human menstrual cycle, the endometrium undergoes remodeling, shedding, and regeneration, all of which are driven by substantial gene expression changes in the underlying cellular hierarchy. Despite its importance in human fertility and regenerative biology, mechanistic understanding of this unique type of tissue homeostasis remains rudimentary. We characterized the transcriptomic transformation of human endometrium at single cell resolution, dissecting the multidimensional cellular heterogeneity of this tissue across the entire natural menstrual cycle. We profiled the behavior of 6 endometrial cell types, including a previously uncharacterized ciliated epithelial cell type, duri…
Helium isotopes distribution in groundwater and thermal waters of Tunisia: relationship to tectonics and geology
2008
Regional variations in the chemical and helium–carbon isotope composition of geothermal fluids across Tunisia
2011
Abstract Tunisia has numerous thermo-mineral springs. Previous studies have shown that their chemical composition and occurrence are strongly influenced by the regional geology. However little work has been done so far to study the isotopic composition of volatiles associated with these geothermal manifestations. Here, we report on the results of an extensive survey of both natural hot springs and production wells across Tunisia, aimed at investigating the spatial distribution of thermal fluids' geochemical characteristics and He–C isotopic composition. The chemistry of the analyzed samples highlights the heterogeneity of the water mineralization processes in Tunisia, as a consequence of th…
Stationary heat flux profile in turbulent helium II in a semi-infinite cylindrical channel
2012
In this paper we determine a set of solutions for a system of partial dif- ferential equations describing stationary heat flux in a semi-infinite cylindrical channel filled with turbulent superfluid helium. This study uses a continuous model for liquid helium II, derived from Extended Thermodynamics, in which the heat flux q is a fundamental variable. The influence of the vortex line den- sity on the radial distribution of the heat flux is especially discussed.