Search results for "Helix"
showing 6 items of 196 documents
Modeling of the N-terminal Section and the Lumenal Loop of Trimeric Light Harvesting Complex II (LHCII) by Using EPR
2015
The major light harvesting complex II (LHCII) of green plants plays a key role in the absorption of sunlight, the regulation of photosynthesis, and in preventing photodamage by excess light. The latter two functions are thought to involve the lumenal loop and the N-terminal domain. Their structure and mobility in an aqueous environment are only partially known. Electron paramagnetic resonance (EPR) has been used to measure the structure of these hydrophilic protein domains in detergent-solubilized LHCII. A new technique is introduced to prepare LHCII trimers in which only one monomer is spin-labeled. These heterogeneous trimers allow to measure intra-molecular distances within one LHCII mon…
Orejas valgas: estabilización mediante colgajo dermo-graso-pericóndrico retroauricular
2013
El tratamiento quirúrgico para la corrección de las orejas prominentes o valgas se basa en crear una distancia de entre 17-21 mm entre el hélix y la mastoides, así como recrear unos pliegues auriculares anteriores bien definidos. Desde finales de 1800 hasta la actualidad se han descrito muchas técnicas para corregir las orejas despegadas, prominentes o valgas, cada una de ellas con sus propias características. En el presente trabajo describimos una técnica para estabilizar el resultado quirúrgico cuando se corrige esta entidad y evitar su recidiva. Se trata de un procedimiento de fijación mastoidea de la oreja mediante un colgajo dermo-graso-pericóndrico de sencillo diseño, útil, seguro y f…
Common variants at VRK2 and TCF4 conferring risk of schizophrenia
2011
To access publisher full text version of this article. Please click on the hyperlink in Additional Links field. Common sequence variants have recently joined rare structural polymorphisms as genetic factors with strong evidence for association with schizophrenia. Here we extend our previous genome-wide association study and meta-analysis (totalling 7 946 cases and 19 036 controls) by examining an expanded set of variants using an enlarged follow-up sample (up to 10 260 cases and 23 500 controls). In addition to previously reported alleles in the major histocompatibility complex region, near neurogranin (NRGN) and in an intron of transcription factor 4 (TCF4), we find two novel variants show…
LA SCALA DI MOMO AI MUSEI VATICANI. Curve coniche gobbe e superfici rigate da esse generate.
2014
This study is part of a more vast research that aims to examine in depth the geometrical-spatial origin of skew curves belonging to conical surfaces of revolution: conical spiral and conical helix. The study begins with an investigation concerning the geometrical tracing, and the spatial origin of both the skew curves and the ruled surfaces they generate, carrying out a comparison of the different formal characteristics through a number of algorithms that control the reference properties, written within the renown Rhinoceros plug-in, Grasshopper. Then follows an in-depth analysis of an admirable example of architecture dating back to the first thirty years of the past century and made by th…
Properties of transmembrane helix TM1 of the DcuS sensor kinase of Escherichia coli, the stator for TM2 piston signaling
2021
Abstract The sensor kinase DcuS of Escherichia coli perceives extracellular fumarate by a periplasmic PASP sensor domain. Transmembrane (TM) helix TM2, present as TM2-TM2′ homo-dimer, transmits fumarate activation in a piston-slide across the membrane. The second TM helix of DcuS, TM1, is known to lack piston movement. Structural and functional properties of TM1 were analyzed. Oxidative Cys-crosslinking (CL) revealed homo-dimerization of TM1 over the complete membrane, but only the central part showed α-helical +3/+4 spacing of the CL maxima. The GALLEX bacterial two-hybrid system indicates TM1/TM1′ interaction, and the presence of a TM1-TM1′ homo-dimer is suggested. The peripheral TM1 regi…
Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus
2010
Apoptosis is a fundamental host defence mechanism against invading microbes. Inactivation of NF-kappaB attenuates encephalomyocarditis virus (EMCV) virulence by triggering rapid apoptosis of infected cells, thereby pre-emptively limiting viral replication. Recent evidence has shown that hypoxia-inducible factor (HIF) increases NF-kappaB-mediated anti-apoptotic response in clear-cell renal cell carcinoma (CCRCC) that commonly exhibit hyperactivation of HIF due to the loss of its principal negative regulator, von Hippel-Lindau (VHL) tumour suppressor protein. Here, we show that EMCV challenge induces a strong NF-kappaB-dependent gene expression profile concomitant with a lack of interferon-me…