Search results for "Helminth Infection"
showing 3 items of 23 documents
Taste, a new incentive to switch to (R)-praziquantel in schistosomiasis treatment.
2009
Background Praziquantel (PZQ) is the drug compound of choice in the control and treatment of schistosomiasis. PZQ is administered as a racemate, i. e. 1∶1 mixture of enantiomers. The schistosomicidal activity arises from one PZQ-enantiomer, whereas the other enantiomer does not contribute to the activity. The WHO's Special Programme for Research and Training in Tropical Diseases (TDR) has assigned the low-cost preparation of pure schistosomicidal (−)-PZQ a key priority for future R&D on PZQ, but so far this transition has not happened. PZQ has two major administration drawbacks, the first being the high dose needed, and its well documented bitter and disgusting taste. Attempts of taste-mask…
S. haematobium as a Common Cause of Genital Morbidity in Girls: A Cross-sectional Study of Children in South Africa
2013
Background Schistosoma (S.) haematobium infection is a common cause of genital morbidity in adult women. Ova in the genital mucosal lining may cause lesions, bleeding, pain, discharge, and the damaged surfaces may pose a risk for HIV. In a heterogeneous schistosomiasis endemic area in South Africa, we sought to investigate if young girls had genital symptoms and if this was associated with urinary S. haematobium. Methodology In a cross-sectional study of 18 randomly chosen primary schools, we included 1057 schoolgirls between the age of 10 and 12 years. We interviewed assenting girls, whose parents had consented to their participation and examined three urines from each of them for schistos…
Parasites as indicators of social structure and stock identity of marine mammals
1995
Abstract Introduction: the use of parasites as biological indicators of marine mammals has not yet received all the necessary attention. The aim of this review is to show the value of parasite data in studies of stock identity and social structure. Methods: the application of the technique to marine mammals is hampered by the lack of control over sampling conditions and the paucity of information about the biology of their parasites. Relevant criteria for, suitable parasite tags are discussed. Case studies: previous work on marine mammals is presented to illustrate the usefulness and limitations of parasite data. A study of pilot whales revealed that differences in helminth infections betwe…