Search results for "Helsinki"

An In-between Reader : Situatedness and Belonging in Tove Jansson’s Helsinki

2021

Finnish-Swedish artist and writer Tove Jansson (1914–2001), widely known as the author of the Moomin books, was born in Helsinki and resided there for the greater part of her life. The city features as a setting for her adult-oriented fiction – notably, semi-autobiographical fix-up novels Sculptor’s Daughter (1968/2015) and Fair Play (1989/2011). This article adopts a situated approach to literary geography, examining the researcher’s own position as a Helsinki resident and a ‘situated’ reader. Using autoethnography as a method, I analyze how the city and Jansson’s life narrative are co-produced by the writer, her texts, texts about her (such as biographies and press articles) and myself as…

Töölön kisahalli ja Myllypuron liikuntamylly pääkaupunkiseutulaisten liikuntapaikkoina

2002

Indeksi liikuntaympäristöjen monipuolisuudesta asukkaiden lähialueella

2023

Liikunta on välttämätöntä terveyden ylläpitämiselle, ja sillä on lukemattomia positiivisia vaikutuksia sekä fyysiseen että psyykkiseen hyvinvointiin. Liikuntaympäristöjen monipuolisuus lähellä kotia voi edistää liikunnan harrastamista ja fyysisesti aktiivista elämäntapaa. Liikunnallisen elämäntavan mahdollistaminen kaikille, etenkin huono-osaisilla alueilla, voi tasoittaa alueiden välisiä hyvinvointieroja ja näin vähentää segregaation vaikutuksia. Suomessa yhdenvertaisten liikuntapalvelujen järjestäminen asukkaille on pääosin kuntien vastuulla. Tässä artikkelissa esittelemme uuden indeksin, jolla voidaan kuvata ja analysoida asukkaiden lähialueella olevien erityyppisten liikuntaympäristöjen…

PNPLA3 Rs738409 C>G Variant Predicts Liver-Related Outcomes in Patients with Non-Alcoholic Fatty Liver Disease

2019

Background: Patients with NAFLD are at higher risk of developing liver-related complications -liver decompensation(LD) and hepatocellular carcinoma (HCC), including death-. A single nucleotide polymorphism in PNPLA3 gene is associated with a higher prevalence of liver damage and HCC, but prospective date are not available. We aimed to assess whether the common rs738409 variant in PNPLA3 gene can predict the occurrence of liver-related events and death in a large cohort of NAFLD patients.   Methods: We considered 471 consecutive Italian individuals with histological diagnosis of NAFLD or clinical diagnosis of compensated NAFLD-related cirrhosis, prospectively followed for at least 6 months. …

Prognostic Impact of 3-HM Concentration in Patients with Alcoholic or Viral Cirrhosis

2018

The role of endotoxemia related to intestinal bacterial translocation in worsening liver disease is the subject of many studies, but its impact on cirrhosis mortality has not been well evaluated. In this study, 3-hydroxymyristate (3-HM) (specific lipid of lipopolysaccharides) was directly quantified by an innovative patented assay with the aim of assessing the impact on cirrhosis mortality. The 3-HM concentration was measured in 593 patients with alcoholic or viral cirrhosis in stable clinical condition. A Cox hazards regression model was used to evaluate association between 3-HM and its fractions bound or nor bound to lipoprotein and the mortality. The 3-HM concentration was increased in p…

<i>PCSK9</i> rs11591147 R46L Loss-of-Function Variant Protects Against Liver Damage in Individuals with NAFLD

2020

Background and Aims: The proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in cholesterol homeostasis, and its inhibition represents an effective therapy to lower LDL-C levels. In this study, we examined the impact of PCSK9 rs11591147 loss-of-function (LOF) variant on liver damage in a multicenter collection of patients at risk of nonalcoholic steatohepatitis (NASH), in clinical samples and experimental models. Methods: We considered 1,874 consecutive individuals at risk of NASH as determined by histology. The SNP rs11591147, encoding for the p.R46L variant of PCSK9, was genotyped by TaqMan assays. We also evaluated 1) PCSK9 mRNA hepatic expression in human liver, and 2…

GEMS, a GEnetic and Metabolic Staging predicting the outcome of non-alcoholic fatty liver disease

2021

Background and Aim: Non-alcoholic fatty liver disease(NAFLD) is an emergent cause of liver-related events(LRE). We have assessed the ability of a composite score based on clinical features, metabolic comorbidities and genetic background, to predict LRE. Methods: 546 consecutive patients with NAFLD were recruited and stratified according to FIB-4(low risk <1.3;intermedium-high risk ≥1.3). LRE were defined as occurrence of HCC or hepatic decompensation. Cox regression multivariate analysis was used to identify baseline variables associated with LRE. Results: Over a median follow-up of 73.8 months, 58 patients experienced LRE(only 1 in the cohort of patients with FIB-4 65 years(HR 17.96), plat…

Health promotion activities of sports clubs and coaches, and health and health behaviours in youth participating in sports clubs: the Health Promotin…

2015

Introduction: Sports clubs form a potential setting for health promotion, but the research is limited. The aim of the Health Promoting Sports Club (HPSC) study was to elucidate the current health promotion activities of youth sports clubs and coaches, and to investigate the health behaviours and health status of youth participating in sports clubs compared to non-participants. Methods and analysis: The study design employs cross-sectional multilevel and multimethod research with aspirations to a prospective cohort study in the next phase. The setting-based variables at sports clubs and coaching levels, and health behaviour variables at the individual level, are investigated using surveys; a…

Biomarker testing of lung cancer in Spain

2019

Abstract Background Target therapy guide by biomarkers have become the standard of care for patients with lung cancer (LC). So, identify those molecular alterations is one of the most important care needs nowdays. Our objective was to know the implementation degree of these tests in a large cohort of patients in Spain using the Thoracic Tumor Registry (TTR) of the Grupo Espanol de Cancer de Pulmon (Spanish Lung Cancer Group). Methods The TTR is an observational cohort multicenter study of LC in Spain. The study is conducted according to the Declaration of Helsinki and approved by the institutional review board of each participating institute. The registry was approved by the Spanish Drug Ag…

Tobacco use in lung cancer (LC) patients (p) in Spain

2019

Abstract Background Tobacco use, mainly as cigarette smoking, is the leading cause of lung cancer. Eighty-five percent of LC occur in smokers. Understanding the Spanish smoking habits allows the government to design health care policies against this consumption. To do so, the Grupo Espanol de Cancer de Pulmon (Spanish Lung Cancer Group) made this analysis within the context of the Thoracic Tumor Registry (TTR). Methods The TTR is an observational cohort multicenter study in Spain. The study is conducted according to the Declaration of Helsinki and approved by the institutional review board of each participating site. The registry was approved by the Spanish Drug Agency, as a non-post-author…