Search results for "Hemodynamic"

showing 10 items of 526 documents

Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol…

2017

Background Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multice…

MaleLung DiseasesTime Factors[SDV]Life Sciences [q-bio]Respiratory Medicine and Allergymedicine.medical_treatmentRESPIRATORY-DISTRESS-SYNDROMEMedicine (miscellaneous)HemodynamicsMechanical ventilation; Obesity; Positive end-expiratory pressure; Postoperative pulmonary complication; Recruitment maneuver; Medicine (miscellaneous); Pharmacology (medical)LAPAROSCOPIC BARIATRIC SURGERYLung DiseaseBody Mass Indexlaw.inventionPositive-Pressure RespirationStudy Protocol0302 clinical medicineMechanical ventilationClinical ProtocolsRandomized controlled trialRisk Factors030202 anesthesiologylawMedicine and Health SciencesClinical endpointAnesthesiaPharmacology (medical)Respiratory function030212 general & internal medicineLungLungmedicin och allergi2. Zero hungerlcsh:R5-920ddc:617Positive end-expiratory pressurerespiratory systemOperative3. Good healthTreatment OutcomeRecruitment maneuverTIDAL VOLUMESResearch DesignMechanical ventilation Positive end-expiratory pressure Recruitment maneuver Obesity Postoperative pulmonary complicationSurgical Procedures OperativeAnesthesiaBreathingFemaleErratumlcsh:Medicine (General)ALVEOLAR RECRUITMENT MANEUVERHumancirculatory and respiratory physiologymedicine.medical_specialtyTime FactorMechanical ventilation ; Obesity ; Positive end-expiratory pressure ; Postoperative pulmonary complication ; Recruitment maneuverAnesthesia GeneralLung injuryMechanical ventilation; Obesity; Positive end-expiratory pressure; Postoperative pulmonary complication; Recruitment maneuver; Body Mass Index; Clinical Protocols; Female; Humans; Intraoperative Care; Lung; Lung Diseases; Male; Obesity; Positive-Pressure Respiration; Protective Factors; Research Design; Risk Factors; Time Factors; Treatment Outcome; Anesthesia General; Surgical Procedures Operative; Medicine (miscellaneous); Pharmacology (medical)NOGENERAL-ANESTHESIADRIVING PRESSURE03 medical and health sciencesmedicineHumansddc:610ObesityClinical ProtocolGeneralProtective FactorPositive end-expiratory pressurePOSTOPERATIVE PULMONARY COMPLICATIONSMechanical ventilationSurgical ProceduresIntraoperative CareINTERNATIONAL CONSENSUSbusiness.industryRisk FactorProtective FactorsSurgeryMechanical ventilation; Obesity; Positive end-expiratory pressure; Postoperative pulmonary complication; Recruitment maneuverrespiratory tract diseasesbusinessPostoperative pulmonary complicationLUNG INJURY
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Perioperative goal-directed hemodynamic therapy based on radial arterial pulse pressure variation and continuous cardiac index trending reduces posto…

2013

Introduction Several single-center studies and meta-analyses have shown that perioperative goal-directed therapy may significantly improve outcomes in general surgical patients. We hypothesized that using a treatment algorithm based on pulse pressure variation, cardiac index trending by radial artery pulse contour analysis, and mean arterial pressure in a study group (SG), would result in reduced complications, reduced length of hospital stay and quicker return of bowel movement postoperatively in abdominal surgical patients, when compared to a control group (CG). Methods 160 patients undergoing elective major abdominal surgery were randomized to the SG (79 patients) or to the CG (81 patien…

MaleMean arterial pressuremedicine.medical_specialtyCardiac indexBlood PressureCritical Care and Intensive Care MedicinePatient Care PlanningPerioperative CarePostoperative ComplicationsMonitoring Intraoperativemedicine.arterymedicineHumansProspective StudiesRadial arteryAgedAged 80 and overArterial pulse pressurebusiness.industryResearchHemodynamicsPerioperativeMiddle AgedSurgeryPulse pressureBlood pressureElective Surgical ProceduresAnesthesiaRadial ArteryFemalebusinessAbdominal surgeryCritical Care
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A Comparison of 2 Mitral Annuloplasty Rings for Severe Ischemic Mitral Regurgitation: Clinical and Echocardiographic Outcomes.

2016

Controversies regarding the choice of annuloplasty rings for treatment of ischemic mitral regurgitation still exist. Aim of the study is to compare early performance of 2 different rings in terms of rest and exercise echocardiographic parameters (transmitral gradient, systolic pulmonary artery pressure, and mitral valve area), clinical outcomes, and recurrence of mitral regurgitation. From January 2008 till December 2013, prospectively collected data of patients who underwent coronary artery bypass grafting and undersizing mitral valve annuloplasty for severe chronic ischemic mitral regurgitation at our Institution were reviewed. A total of 93 patients were identified; among them 44 had sem…

MaleMitral Valve AnnuloplastyTime FactorsMyocardial IschemiaHemodynamics030204 cardiovascular system & hematologySeverity of Illness IndexVentricular Function Left0302 clinical medicinePostoperative ComplicationsRecurrenceMitral valve annuloplastyMitral valve030212 general & internal medicineHospital MortalityHeart Valve Prosthesis ImplantationExercise ToleranceIschemic mitral regurgitationMitral Valve InsufficiencyGeneral MedicineMiddle Agedmedicine.anatomical_structureTreatment OutcomeItalyHeart Valve ProsthesisCardiologyMitral ValveFemaleCardiology and Cardiovascular MedicineArteryEchocardiography StressPulmonary and Respiratory Medicinemedicine.medical_specialtyProsthesis Design03 medical and health sciencesInternal medicinemedicine.arterymedicineHumansMitral AnnuloplastyAgedRetrospective StudiesMitral regurgitationbusiness.industryRecovery of FunctionSurgeryPulmonary arteryChronic DiseaseExercise TestSurgerybusinessSeminars in thoracic and cardiovascular surgery
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Novel Small Molecule Inhibitor of C1s Exerts Cardioprotective Effects in Ischemia-Reperfusion Injury in Rabbits

2001

Abstract Myocardial ischemia-reperfusion injury can be related to complement activation with generation of chemotactic agents, adhesion molecule expression, release of cytokines and oxygen-derived free radicals, and subsequent neutrophil accumulation. In the present study the cardioprotective effects of a novel highly selective small molecule C1s inhibitor (C1s-INH-248, Knoll) were examined in a rabbit model of myocardial ischemia (I) and reperfusion (R; i.e., 60 min I + 180 min R). In in vitro tests (enzyme activity and SRBC lysis) C1s-INH-248 demonstrated profound inhibitory potency. In vivo C1s-INH-248 (1 mg/kg body weight) administered 5 min before reperfusion significantly attenuated m…

MaleNecrosisEndotheliumNeutrophilsG proteinImmunologyMyocardial IschemiaIschemiaMyocardial Reperfusion InjuryComplement C1 Inactivator ProteinsPharmacologyHemolysisLeukocyte CountClassical complement pathwaySuperoxidesIn vivomedicineAnimalsImmunology and AllergyComplement Activationbusiness.industryHemodynamicsmedicine.diseaseComplement systemmedicine.anatomical_structureAnesthesiaEndothelium VascularRabbitsmedicine.symptombusinessReperfusion injuryThe Journal of Immunology
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The Effects of Sodium Nitroprusside-Induced Hypotension on Splanchnic Perfusion and Hepatocellular Integrity

1999

UNLABELLED The purpose of our study was to investigate the effects of sodium nitroprusside-induced hypotension on splanchnic perfusion and hepatocellular integrity. Thirty patients undergoing radical prostatectomy were allocated randomly to a sodium nitroprusside (SNP) or control group (control). Regional pco2 was measured using gastric tonometry, and the regional to arterial difference in partial pressure of CO2 and intramucosal pH were calculated. The cytosolic liver enzyme alpha-glutathione S-transferase and standard liver enzyme markers (alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyltransferase) were also measured. Mean arterial pressure in the SNP group was 50…

MaleNitroprussideMean arterial pressuremedicine.medical_specialtyPartial PressureVasodilator AgentsUrologyHemodynamicsBlood PressurepCO2medicineHumansSplanchnic CirculationGastric tonometryAntihypertensive AgentsGlutathione TransferaseProstatectomybusiness.industryLiver DiseasesCarbon DioxideMiddle AgedIsoenzymesOxygenAnesthesiology and Pain MedicineLiverAnesthesiaSodium nitroprussideLiver functionChemical and Drug Induced Liver InjuryHypotensionSplanchnicbusinessPerfusionBiomarkersmedicine.drugAnesthesia & Analgesia
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A Scanning Technique to Measure Regional Cerebral Blood Flow and Oxyhemoglobin Level

2001

OBJECTIVE: The application of a laser scanning technique to measure regional cerebral blood flow (CBF) and tissue hemoglobin oxygenation (HbO 2 ) using the rat closed cranial window preparation is described. METHODS: Twenty-nine male Wistar rats were used to consecutively measure local CBF by laser Doppler flowmetry and tissue HbO 2 by a microspectrophotometric method at multiple corresponding cortical locations. The scanning technique used a computer-controlled micromanipulator. Data from three experimental models are presented: the whisker stimulation model, the ischemia-reperfusion model, and the sinus-vein thrombosis model. Sequential changes in local CBF and HbO 2 data before, during, …

MaleOptics and PhotonicsIschemiaHemodynamicsStimulationBrain IschemiaPhysical StimulationLaser-Doppler FlowmetrymedicineAnimalsSagittal Sinus ThrombosisRats WistarBalayagebusiness.industryBrainOxygenationLaser Doppler velocimetrymedicine.diseaseThrombosisRatsCerebral blood flowSpectrophotometryCerebrovascular CirculationOxyhemoglobinsReperfusion InjuryVibrissaeAnesthesiaSurgeryNeurology (clinical)businessBiomedical engineeringNeurosurgery
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First-degree atrioventricular block and pseudopacemaker syndrome

2013

MalePacemaker Artificialmedicine.medical_specialtySystoleVena Cava InferiorInferior vena cavaVentricular Function LeftHeart RateInternal medicinemedicineHumansCardiac OutputAtrioventricular BlockAged 80 and overBloc atrioventriculaire du premier degrébusiness.industryCardiac Pacing ArtificialHemodynamicsSynchronisme atrioventriculaireGeneral MedicineFirst degree AV blockmedicine.diseaseEchocardiography DopplerPacemakerFirst-degree AV blockStimulateur cardiaqueTreatment Outcomemedicine.veinRegional Blood FlowFirst-degree atrioventricular blockElectrocardiography AmbulatoryCardiologyAV synchronyCardiology and Cardiovascular MedicinebusinessAtrioventricular blockArchives of Cardiovascular Diseases
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ASSOCIATION OF RENAL RESISTIVE INDEX WITH MARKERS OF EXTRARENAL VASCULAR CHANGES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2016

Introduction: Recent data suggest that renal hemodynamic parameters obtained by duplex Doppler sonography, especially the intrarenal resistive index (RRI), may be associated with systemic vascular changes. However, limited and conflicting data exist about the relationship between aortic stiffness and RI in autoimmune diseases, like systemic lupus erythematosus (SLE). Aim: To evaluate the relationship between RRI and arterial stiffness, assessed by aortic pulse wave velocity (aPWV), and between RRI and carotid atherosclerosis, evaluated by intima-media thickness (IMT) measurement in patients with SLE. Methods: In this cross-sectional study, we enrolled 39 SLE subjects (mean age 39 years) tha…

MalePathologyRadiology Nuclear Medicine and ImagingSettore MED/09 - Medicina InternaAcoustics and UltrasonicsSLE030204 cardiovascular system & hematologyCarotid Intima-Media Thickness0302 clinical medicineLupus Erythematosus Systemicskin and connective tissue diseasesPulse wave velocityAortaRadiological and Ultrasound TechnologyRENAL RESISTIVE INDEXAortic stiffneAtherosclerosicardiovascular systemCardiologyAortic stiffnessFemaleAdultmedicine.medical_specialtyMean arterial pressureAmbulatory blood pressureBiophysicsRenal functionSystemic lupus erythematosuPulse Wave AnalysisSensitivity and SpecificityRenal Circulation03 medical and health sciencesCAROTID IMTVascular StiffnessInternal medicinemedicineHumansIn patient030203 arthritis & rheumatologySettore MED/14 - NefrologiaRenal hemodynamicbusiness.industryReproducibility of ResultsUltrasonography Dopplermedicine.diseaseAtherosclerosisResistive indexPulse wave velocitySettore MED/16 - ReumatologiaArterial stiffnessbusinesshuman activitiesBiomarkers
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Immune escape mechanism: defective resting and stimulated leukocyte-endothelium interaction in hepatocellular carcinoma of the rat.

2004

Hepatocellular carcinoma represents an increasing therapeutic challenge due to its high incidence and early metastasis. Numerous studies have demonstrated the influence of the vascular system on tumor growth and development. In addition, the role of leukocyte-endothelium interaction in tumor vessels is of particular significance with regard to immunological tumor therapy. In this study we used an experimental in vivo animal model that allows a quantitative analysis on vessel morphology, microcirculation, and leukocyte-endothelium interaction. The vessel architecture in tumor tissue was found to be extremely heterogeneous, with a consecutively variable blood flow velocity. Following superfus…

MalePathologymedicine.medical_specialtyCell signalingCarcinoma HepatocellularEndotheliumPhysiologyCell CommunicationBiologyMetastasisMicrocirculationNeovascularizationmedicineLeukocytesAnimalsChemotactic FactorsNeovascularization PathologicCell adhesion moleculeMicrocirculationLiver NeoplasmsGastroenterologyHemodynamicsChemotaxismedicine.diseaseRatsRats Inbred ACImedicine.anatomical_structureLiverModels AnimalEndothelium Vascularmedicine.symptomLiver cancerCell Adhesion MoleculesBlood Flow VelocityDigestive diseases and sciences
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Stimulation of regional lymphatic and blood flow by epicutaneous oxazolone.

2002

The application of the epicutaneous antigen oxazolone results in persistent induration and erythema; however, the relative changes in lymph and blood flow in the inflammatory skin are largely unknown. To define the contribution of lymph and blood flow to the clinical appearance of cutaneous inflammation, we studied the sheep ear after the application of oxazolone. As a model for the study of these changes, the sheep ear had several experimental advantages: 1) a simplified superficial vascular network, 2) defined lymphatic drainage, and 3) an avascular and alymphatic cartilaginous barrier. Lymph flow was continuously monitored by cannulation of the prescapular efferent lymph duct. Blood flo…

MalePathologymedicine.medical_specialtyErythemaPhysiologyHemodynamicsVascular permeabilityMicrocirculationOxazolonechemistry.chemical_compoundAdjuvants ImmunologicPhysiology (medical)MedicineAnimalsSkinSheepbusiness.industryOxazoloneEarBlood flowLymphatic systemchemistryImmunologyBlood CirculationLymphDrug EruptionsLymphmedicine.symptombusinessJournal of applied physiology (Bethesda, Md. : 1985)
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