Search results for "Hemorheology"
showing 3 items of 23 documents
Modification of human platelet adhesion on biomaterial surfaces by protein preadsorption under static and flow conditions.
2004
Biomaterial-induced thrombosis remains one of the main complications of vascular implant devices. Preadsorbed proteins on the biomaterial/blood interface will modify the adhesion and activation of platelets (PTLs) during the initial contact-phase. Our results clearly show that PTL-adherence on biomaterials is influenced not only by protein preadsorption, but also by flow conditions. The covalent coating of TCPS and glass by phosphorylcholine (PC) induces a significant decrease of PTL adhesion but leads to a slight, but nevertheless significant activation of PTL, which was detected by the induction of P-selectin expression using FACS analysis. Methodologically, the visualization of PTL adhes…
Perspectives in Clinical Hemorheology and Microcirculation: Review of the Conference of the German Society for Clinical Microcirculation and Hemorheo…
2011
During the 29th conference of the German Society for Clinical Microcirculation and Hemorheology – held in the Freie Universitat Berlin a broad range of different topics of experimental and clinical studies in the field were presented. A special spotlight was dedicated to the Conference President’s (Prof. Dr. J. Plendl, Head of the Department of Veterinary Anatomy) scientific area “Anatomical and Experimental Microcirculation” [5, 6, 9, 13]. Of special interest were the angiogenetic studies: Examinations of the influence of PDGF-BB on adipose-tissue derived stem cells and how these influence angiogenesis [9] and the angiogenesis and healing with non-shrinking, fast degradable PLGA/CaP scaffo…
Oxidative stress in cardiovascular disease: successful translation from bench to bedside?
2007
Over the last decades, sound evidence has been generated that oxidative stress is one of the most potent inductors of endothelial dysfunction and is involved at all stages of atherosclerotic plaque evolution.1,2 Experimental and animal models provide a clear association between the amount of oxidative challenge and reversible vascular dysfunction that can be observed before permanent alterations of the vessel wall occur. Article p 1367 Important for cardiovascular biology is the consumption of nitric oxide (NO) by reactive oxygen species. Endothelium relaxant factor is a central molecule in vascular homeostasis as a modulator of endothelial tone and reactivity.3 It is produced by NO synthas…