Search results for "Hep"
showing 10 items of 12243 documents
Evaluation of the animal-assisted therapy in Alzheimer's disease
2017
Animal-assisted therapy sessions have been set up in a protected unit for patients with a dementia-related syndrome. The aim is to measure the effects of animal-assisted therapy on behavioural disorders in daily life and care. The results obtained provided some interesting areas to explore and recommendations with a view to optimising the implementation of such a system.
Dipeptidyl Enoates As Potent Rhodesain Inhibitors That Display a Dual Mode of Action
2015
Dipeptidyl enoates were prepared through a high-yielding two-step synthetic route. They have a dipeptidic structure with a 4-oxoenoate moiety as a warhead with multiple reactive sites. Dipeptidyl enoates were screened against rhodesain and human cathepsins B and L, and were found to be potent and selective inhibitors of rhodesain. Among them (S,E)-ethyl 5-((S)-2-{[(benzyloxy)carbonyl]amino}-3-phenylpropanamido)-7-methyl-4-oxooct-2-enoate (6) was the most potent, with an IC50 value of 16.4 nm and kinact/Ki=1.6×106 m−1 s−1 against rhodesain. These dipeptidyl enoates display a reversible mode of inhibition at very low concentrations and an irreversible mode at higher concentrations. Inhibition…
El impacto de la inmunosupresión precoz en las complicaciones no asociadas al injerto hepático
2018
La falta de mejora a largo plazo de los resultados post-TH se debe en gran medida a complicaciones no asociadas al injerto en principio muy relacionadas con la exposición crónica a IS. En diferentes estudios se ha demostrado como la minimización de los ICN tiene un efecto protector en términos de toxicidad renal, metabólica, cardíaca y oncogénica. Sin embargo, no existe una evidencia sólida sobre el impacto que pueda tener la IS precoz, es decir aquella administrada en el post-trasplante inicial, y el desarrollo de dichas complicaciones. El grupo de Rodríguez-Perálvarez ha demostrado que tanto los niveles de Tac mayores de 10 ng/mL durante los primeros 15 días post-TH como la presencia de p…
Two-particle transverse momentum correlations in pp and p-Pb collisions at energies available at the CERN Large Hadron Collider
2023
Two-particle transverse momentum differential correlators, recently measured in Pb--Pb collisions at energies available at the CERN Large Hadron Collider (LHC), provide an additional tool to gain insights into particle production mechanisms and infer transport properties, such as the ratio of shear viscosity to entropy density, of the medium created in Pb-Pb collisions. The longitudinal long-range correlations and the large azimuthal anisotropy measured at low transverse momenta in small collision systems, namely pp and p-Pb, at LHC energies resemble manifestations of collective behaviour. This suggests that locally equilibrated matter may be produced in these small collision systems, simil…
Työn ja perheen yhteensovittamisen ongelma vanhemmuuden ja yritysorganisaation näkökulmasta
2005
Search for photons with energies above 1018 eV using the hybrid detector of the Pierre Auger Observatory
2017
A search for ultra-high energy photons with energies above 1 EeV is performed using nine years of data collected by the Pierre Auger Observatory in hybrid operation mode. An unprecedented separation power between photon and hadron primaries is achieved by combining measurements of the longitudinal air-shower development with the particle content at ground measured by the fluorescence and surface detectors, respectively. Only three photon candidates at energies 1-2 EeV are found, which is compatible with the expected hadron-induced background. Upper limits on the integral flux of ultra-high energy photons of 0.027, 0.009, 0.008, 0.008 and 0.007 km-2 sr-1 yr-1 are derived at 95% C.L. for ener…
Dis grand-mère, est-ce que tu as des belles dents ?
2022
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
2020
2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…
Perhepäivähoito- ja päiväkoti-instituutio varhaiskasvatuksen kunnallisten viranhaltijoiden puheessa
2022
Tutkimuksessa tarkasteltiin perhepäivähoito- ja päiväkoti-instituutioiden tuottamista varhaiskasvatuksesta vastaavien kunnallisten viranhaltijoiden puheessa. Tutkimus tehtiin kymmenessä suomalaisessa kunnassa, ja aineistona käytettiin teemahaastatteluja (N =42). Perhepäivähoito ja päiväkotitoiminta ymmärrettiin diskursiivisen institutionalismin näkökulmasta sosiaalisina käytäntöinä, joiden merkitykset ilmenevät ja muuttuvat varhaiskasvatuksen instituutioiden kielenkäytössä. Aineistoa analysoitiin diskursiivisesti, ja puheesta erotettiin vaihtelevia tapoja puhua perhepäivähoidosta ia päiväkotitoiminnasta. Löydetyissä puhetavoissa perhepäivähoidolle ja päiväkotitoiminnalle tuotettiin erilaise…