Search results for "Hf"
showing 10 items of 909 documents
CHF2819: Pharmacological profile of a novel acetylcholinesterase inhibitor
2002
CHF2819 is a novel orally active acetylcholinesterase inhibitor (AChEI) developed for the treatment of Alzheimer's disease (AD). CHF2819 is a selective inhibitor of AChE, it is 115 times more potent against this enzyme than against butyrylcholinesterase (BuChE). Moreover, CHF2819 is more selective for inhibition of central (brain) AChE than peripheral (heart) AChE. In vivo CHF2819, 0.5, 1.5, and 4.5 mg/kg p.o., significantly and in dose-dependent manner increased acetylcholine (ACh) levels in hippocampus of young adult rats. Moreover, aging animals, with lower basal ACh levels than young adult rats, also exhibit a marked increase in hippocampal levels of this neurotransmitter after administ…
Emergency hernia repair in the elderly: multivariate analysis of morbidity and mortality from an Italian registry
2020
Abstract Purpose The incidence of inguinal hernia is higher in elderly because of aging-related diseases like prostatism, bronchitis, collagen laxity. A conservative management is common in elderly to reduce surgery-related risks, however watchful waiting can expose to obstruction and strangulation. The aim of the present study was to assess the impact of emergency surgery in a large series of elderly with complicated groin hernia and to identify the independent risk factors for postoperative morbidity and mortality. The predictive performance of prognostic risk scores has been also assessed. Methods This is a prospective observational study carried out between January 2017 and June 2018 in…
Theoretical Approaches on Successful Email Marketing Campaigns
2016
Nowadays, the consumer has extremely varied product options. E-mail marketing could be atool to complement traditional marketing activities by increasing customer engagement, and whichdoes not involve high costs. While there have been many predictions for years that email marketing will be replaced withsomething else, it remained one of the most useful ways to reach current and potential customers. This paper aims to bring some clarifications on what could bring success to email marketingcampaigns. Responses are related to how sent emails can draw the attention of people (ie how theycan be observed), given that, users’ inboxes are invaded by messages of all kinds, how to measurethe results …
Millennials, Peer-to-Peer Accommodation and the Hotel Industry
2016
Today’s world market is a buyer’s market and the new customers, the millennials, are thoughtto be distinctively different than others. Technologically comfortable, the most educated generationever, multitaskers, and strongly influenced by friends and peers, millennials have a different buyingbehaviour and other expectations from service providers. Thus, companies from the hospitalityindustry and policy makers face a number of challenges in trying to meet their (future) demands. Atthe same time, the “sharing economy” has led to the rise of the peer-to-peer accommodation sectorand to a new business model (Airbnb). The aim of this paper is to present these challenges for the hotel industry, be…
Impact du diabete de type 2 sur l'etat de type “dépressif” chez la souris
2013
La liste des auteurs est incomplète.; absent
Positive Motivation of the Employees – One of the Organizations’ Extremely Important Aspects
2020
A current and important issue, on which depends the success of the companies, is the problem of effective motivation. The specialized literature it is very generous in approaching the concept of motivation, due to its major role in meeting the organization’s objectives. The effects of organizational motivation are and will remain particularly broad, as it targets the most valuable resource of an organization - the staff, with its skills, know-how and energy. The purpose of this paper is to determine an to prove that the positive motivation of employees is a basic condition for the organization’s survival and success, being a priority and also an art and a continuous effort.
Análisis del la relación del genotipado y marcadores de estrés oxidativo con la presencia y grado de vasculopatía periférica en pacientes con diabete…
2014
RESUMEN: Padecer diabetes tipo 2 (DM2) ejerce un efecto independiente y multiplicador en la incidencia de complicaciones vasculares, añadido a la presencia de factores de riesgo clásicos. No todos los diabéticos desarrollan con la misma gravedad la vasculopatía periférica (VP). Este riesgo está presente en la fase de prediabetes, donde las complicaciones vasculares pueden preceder a la aparición de la propia diabetes. La biología vascular ha puesto de manifiesto la participación de otros factores como el estrés oxidativo (EO) y el estado crónico inflamatorio en el incremento de este riesgo. Los principales sistemas conocidos de EO a nivel endotelial generan especies reactivas de oxígeno. Pa…
Study on the Correlation Between Working Capital and Economic Value Added for the Companies Relating to the Hotel and Restaurant Industry Listed on t…
2020
In the present study was determined the influence of the value change of the working capital on the variation of the economic value added indicator on a sample consisting of a number of 26 companies (2007-2017) belonging to the hotel and restaurant industry, listed on the Bucharest Stock Exchange. The correlation between the indicators was achieved by using the multiple linear regression method. The study showed that there is a strong link between the two economic indicators, over 80% of the change in economic value being explained by the change in working capital. It was found that a 1% increase in working capital, for the period 2007-2017, had the effect of increasing the economic value a…
The Influence of Hedonic and Utilitarian Motivators on Likelihood to Buy a Tourism Package
2013
To fully understand the pattern of choice, it is important that any explanation of consumer behavior to be accompanied by a complete understanding of the interplay between a consumer’s functional goals and experiential preferences within the decision context. Consumer researchers have increasingly begun to investigate consumer choice based on distinctions that involve the purchase and consumption of goods for pleasure versus for more utilitarian and instrumental purposes. Consumers are often faced with these types of choices between hedonic and utilitarian alternatives that are at least partly driven by emotional desires rather than cold cognitive deliberations. This research approaches fac…
Buying Intentions Influenced by Various Determinants in Tourism
2014
Marketing has acquired a central role in tourism because it helps organizations to create value in transactions with buyers. Thus, this important area of any business process is used to educate consumers, to add value to their experience in tourism, and to seek new ways to reward loyalty through innovative schemes (e.g., programs for frequent travelers). This paper presents the examination of the responses of 154 tourists in relation to their intention to purchase a travel package and the factors that are usually decisive in the decision making process regarding tourism services, factors that could also create the loyalty that any tourism enterprise can create through marketing.