Search results for "High dose"
showing 10 items of 36 documents
Tryptophan immunoadsorption during pregnancy and breastfeeding in patients with acute relapse of multiple sclerosis and neuromyelitis optica.
2017
Background: Up to every fourth woman with multiple sclerosis (MS) or neuromyelitis optica spectrum disorder (NMOSD) suffers a clinically relevant relapse during pregnancy. High doses of steroids bear some serious risks, especially within the first trimester of pregnancy. Immunoadsorption (IA) is an effective and more selective treatment option in disabling MS relapse than plasma exchange. Data on the use of IA during pregnancy and breastfeeding are scarce. Methods: In this retrospective multicenter study, we analyzed the safety and efficacy of IA treatment in acute relapses during pregnancy or breastfeeding. The primary outcome parameter - change of acute relapse-related disability after IA…
Sex differences in estimation of time intervals and in reaction time are removed by moderate but not high doses of caffeine in coffee
2002
Estimation of the passage of time in the seconds-to-minutes range and reaction time are strongly dependent on a hypothetical internal clock. Dopamine is the neurotransmitter most closely related to the rate of this clock. Caffeine, probably the most consumed drug in the world, leads to an augmentation of dopamine neurotransmission. In this study coffee, which reproduces the conditions under which caffeine is normally ingested, containing 3, 75, 150 or 300 mg of caffeine, was given to healthy male and female volunteers. A computerized time estimation and reaction time test was carried out 50 min after ingestion. Sex differences in placebo control subjects (who took decaffeinated coffee with …
Pre-treatment with high doses of cocaine decreases the reinforcing effects of cocaine in the conditioned place preference paradigm.
2012
The aim of the present study was to determine if pre-exposure to high doses of cocaine can subsequently alter the rewarding effects of this drug. Adult male mice received a pretreatment of physiological saline, or 12.5 or 25 mg/kg of cocaine (one injection a day for five days). After an interval of six days without injections, the rewarding effects of low doses of cocaine (0.5, 1 or 1.5 mg/kg) were evaluated in the conditioned place preference (CPP) paradigm. Doses of 1 and 1.5 mg/kg induced a clear CPP in animals pre-treated with saline but were ineffective in those pre-treated with 25 mg/kg of cocaine. Only the dose of 1.5 mg/kg induced CPP in mice pre-treated with 12.5 mg/kg of cocaine. …
FMECA Analyses of radiological over-exposure accident to patients in brachytherapy
2012
This paper presents safety analyses of accidental events which can involve patient during High Dose Rate brachytherapy treatment in over-exposures. The study has been performed by using the well-known techniques FMECA modified by Fuzzy logic theory. Moreover, fuzzy HEART methodology was employed in order to evaluate human error probabilities for each treatment stage. The obtained results, aimed to obtain a list of the deviations with a reasonable probability to produce significant adverse outcomes, provided some recommendations for procedures and safety equipments to reduce the occurrence of radiological over-exposure accidents.
TEATRO MUSICAL Y PERSPECTIVA DE GÉNERO: LA OBRA SICALÍPTICA DE VICENTE LLEÓ DURANTE SU ETAPA EN EL TEATRO ESLAVA DE MADRID (1907-1912)
2020
A principios del siglo XX surgió un nuevo modelo de teatro bufo denominado género sicalíptico caracterizado por sus altas dosis de frivolidad y erotismo que hizo furor en la escena madrileña. Vicente Lleó Balbastre (1870-1922) fue el máximo exponente del género en el teatro musical. Bajo su dirección, como empresario y compositor, el Teatro Eslava se convirtió en el templo de la sicalipsis. En este artículo se estudia el nacimiento y eclosión del género, se recopilan todas las obras sicalípticas de Vicente Lleó en la época dorada de la sicalipsis en el teatro musical y se analizan las principales características de su estilo compositivo.
Effects of chronic administration with high doses of testosterone propionate on behavioral and physiological parameters in mice with differing basal …
2003
The effects of testosterone propionate, an anabolic-androgenic steroid, on the behavior displayed during a social encounter by gonadally intact male mice were investigated. Animals were distributed into three groups according to their attack latency in a pre-screening test (high-, moderate-, and low-attacking mice) and each group received weekly injections of 60 or 120 mg/kg of testosterone or sesame oil for 10 weeks. Behavioral tests were then carried out. Afterwards, organs were weighed and blood samples collected in order to obtain hormonal data. Treatment had a differential impact on attack in the three groups of animals. Only the high-attacking testosterone-treated mice showed lower to…
Nuclear Power, No Thanks?
2012
The greatest misunderstanding related to nuclear energy, which is continuously exploited by its opponents, is the nature of radioactivity. Pierre and Marie Curie carried in the pockets of their laboratory coats test tubes full of highly radioactive substances, unaware that gamma radiation could be harmful at high doses. In contrast, antinuclear propaganda has been so effective that most people are convinced that any radioactive “leakage” is deadly or that radioactive waste has to be buried at a depth of kilometers to avoid harmful effects—in fact, a few meters of soil is enough to absorb even the most intense gamma radiation—or that cancer risk grows exponentially due to nuclear power plant…
Oral glutathione increases hepatic glutathione and prevents acetaminophen toxicity
1990
Administration of oral glutathione (GSH) increases hepatic GSH levels in fasted rats, in mice treated with GSH depletors such as diethylmaleate and in mice treated with high doses of paracetamol. An increase in hepatic GSH levels after administration of oral GSH does not occur in animals treated with buthionine suphoximine, an inhibitor of GSH synthesis. Administration of oral GSH leads to an increase in the concentration of L-cysteine, a precursor of GSH, in portal blood plasma. Oral administration of L-methio-nine to fasted rats produced a significant decrease of hepatic ATP, but not in fed rats. Administration of N-acetyl-cysteine or GSH did not affect the hepatic ATP levels. The results…
IVIG in APS pregnancy
2004
For more than two decades, the intravenous administration of high doses of IgG pooled from the plasma of healthy donors (immune globulin therapy, also known as ‘IVIG’) has benefited patients with a variety of autoimmune disorders. A potential therapeutic role of IVIG in the prevention of thrombosis and of miscarriages in antiphospholipid syndrome (APS) has been postulated. Multicenter randomized controlled trials attempted to define the role of IVIG in preventing pregnancy complications in APS indicate that simple anticoagulation could not be completely satisfactory, and certain patient subgroups might take advantage of IVIG therapy alone or in combination with heparin.
Efficacy and Safety of IQYMUNE®, a Ten Percent Intravenous Immunoglobulin in Adult Patients With Chronic, Primary Immune Thrombocytopenia
2018
Background: Intravenous immunoglobulin (IVIG) IQYMUNE® is a highly purified 10% IVIG that was assessed using the new stringent definition of response described in the revised guideline on the clinical investigation of IVIG. The efficacy and the safety of IQYMUNE® were investigated in adult patients with chronic primary immune thrombocytopenia (ITP). Methods: In this phase III multinational, multicentre, prospective, uncontrolled, open-label, single-arm study, adult patients with a baseline platelet count < 30 × 10 9 /L were treated with IVIG 10% at a dose of 2 g/kg body weight administered over 2 consecutive days. The primary endpoint was Response over the study period and was defined accor…