Search results for "High fat diet"

showing 3 items of 13 documents

MATERNAL HIGH FAT DIET CONSUMPTION DURING PREGNANCY AND LACTATION: IMPACT ON INTESTINAL MORPHOLOGY AND FUNCTION IN PREWEANING OFFSPRING

2015

Different evidence supports an important role for maternal obesity in the development of childhood obesity and subsequent adult disease. This study is addressed to investigate if and to which extend maternal high fat feeding would induce compensatory and adaptative responses in gut predisposing to the eventual development of paediatric obesity. Adult female mice were divided into two groups fed with i) high fat (HF) diet and ii) standard chow (SC)diet, during pregnancy and lactation. HF mothers showed a significant weight gain, higher levels of blood glucose and an abnormal glucose tolerance compared to SC mother, indicating the establishment of metabolic syndrome. Then, offspring subdivide…

gastrointestinal tract maternal obesity high fat dietSettore BIO/09 - Fisiologia
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Glucagon-like peptide-2 analog and inflammatory state in obese mice

2020

Obesity is characterized by chronic low grade of systemic inflammation that develops in response to nutrient excess and plays a key role in the pathogenesis of insulin resistance. It is characterized by macrophage infiltration into adipose tissue (AT) and abnormal cytokine production. These factors damage the metabolic homeostasis leading to alteration in the insulin signaling in specific tissues and organs such as AT and liver. Thus, obese subjects develop over the time resistance to the cellular actions of insulin. Glucagon like peptide-2 (GLP-2) is an intestinal proglucagon-derived hormone released together with GLP1, in response to the passage of food by the distal small intestine. Once…

medicine.medical_specialtybusiness.industryEndocrinology Diabetes and MetabolismGlucagon-like Peptide-2 AnalogMice Obesemedicine.diseaseSettore BIO/09 - FisiologiaGlucagon-Like Peptide-1 ReceptorPeptide FragmentsMiceEndocrinologyEndocrinologyGlucagon-Like Peptide 1Diabetes mellitusInternal medicineGlucagon like peptide-2 (GLP-2) obese high fat diet (HFD) mice inflammation insulin signaling.Glucagon-Like Peptide 2medicineAnimalsInsulinbusinessObese MiceEndocrine
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High-intensity interval training and moderate intensity training with exogenous adenosine counteract development of obesity in rats

2022

Objectives High-Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) can combat the obesity epidemic. However, studies comparing their effects on obesity show controversial findings regarding weight loss. Adenosine has emerged as a possible, novel therapeutic agent to treat obesity, but more preclinical studies on its efficacy are needed. Therefore, the objectives of this study were to compare the effects of HIIT and MIT on obesity, and further to determine the dose-dependent effects of adenosine on body weight. Equipment and methods We induced obesity in male Wistar rats with high-fat diet (HFD) and monitored development of obesity by comparing the weight to rats on nor…

obesityexercisekuntoliikuntaadenosiiniintervalliharjoitteluModerate Intensity Training (MIT)painonhallintaenergy intakelihavuusOrthopedics and Sports Medicineexogenous adenosineHigh-Intensity Interval Training (HIIT)weight losskoe-eläinmallitisocaloricHigh Fat diet (HFD)
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