Search results for "Hormona"
showing 10 items of 183 documents
Do Patients with Luminal A Breast Cancer Profit from Adjuvant Systemic Therapy? A Retrospective Multicenter Study
2016
Background Luminal A breast cancers respond well to anti-hormonal therapy (HT), are associated with a generally favorable prognosis and constitute the majority of breast cancer subtypes. HT is the mainstay of treatment of these patients, accompanied by an acceptable profile of side effects, whereas the added benefit of chemotherapy (CHT), including anthracycline and taxane-based programs, is less clear-cut and has undergone a process of critical revision. Methods In the framework of the BRENDA collective, we analyzed the benefits of CHT compared to HT in 4570 luminal A patients (pts) with primary diagnosis between 2001 and 2008. The results were adjusted by nodal status, age, tumor size and…
APOPTOSIS RATE IN CUMULUS CELLS AS POSSIBLE MOLECULAR BIOMARKER FOR OOCYTE COMPETENCE.
2017
Several lines of evidence showed that apoptosis rate of cumulus cells in oocytes derived by assisted reproductive technologies could be used as an indicator of fertilizing gamete quality. Aim of the study was to investigate the effects of three different ovarian stimulation protocols on the biological and clinical outcome in hyporesponder patients. Collected data showed a higher significant rate of DNA fragmentation index (DFI) in U group (patients treated with Highly Purified human Menopausal Gonadotrophin) than in P group (treated with recombinant human Follicle Stimulating Hormone (r-hFSH) combined with recombinant human Luteinizing Hormone (r-hLH)). Both groups R (treated with r-hFSH al…
NUTRITIONAL AND HORMONAL FACTORS AFFECTING FRUIT SET IN AVOCADO (Persea americana Mill.)
2017
Under favourable conditions, the avocado sets more fruits than the tree is able to bring to maturity, so that the plant adjusts, during the early stages of development, its ability to nourish them by modifying their number, that is, causing the fruit drop of those who can not maintain their growth rate. Accordingly, carbohydrate availability could be a key factor in the physiological abscission of these fruits. Since this species presents dichogamy, the abscission of fruits has also been attributed to the absence of pollination, but at the same time it has been related to failures in seed development, embryo abortion, seed coat collapse, and with the effect of an environmental stress, espec…
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity Habits
2020
While the detrimental effects of a chronic positive energy balance due to a sedentary lifestyle have been well established, the impacts of a short period of abruptly reduced physical activity and overeating arising from strict confinement due to the COVID-19 pandemic will soon start to emerge. To reasonably anticipate major consequences according to the available evidence, we hereby review the literature for studies that have explored the health impacts of several weeks of a reduction in physical activity and daily step-count combined with modified eating habits. These studies identify as main metabolic consequences increases in insulin resistance, total body fat, abdominal fat and inflamma…
Tamoxifen-loaded polymeric micelles: preparation, physico-chemical characterization and in vitro evaluation studies.
2004
Several samples of polymeric micelles, formed by amphiphilic derivatives of PHEA, obtained by grafting into polymeric backbone of PEGs and/or hexadecylamine groups (PHEA-PEG-C(16) and PHEA-C(16)) and containing different amount of Tamoxifen, were prepared. All Tamoxifen-loaded polymeric micelles showed to increase drug water solubility. TEM studies provided evidence of the formation of supramolecular core/shell architectures containing drug, in the nanoscopic range and with spherical shape. Samples with different amount of encapsulated Tamoxifen were subjected to in vitro cytotoxic studies in order to evaluate the effect of Tamoxifen micellization on cell growth inhibition. All samples of T…
El perfil del maltractador masclista. Què ens diu la seua biologia?
2014
La consideracio dels marcadors psicobiologics de predisposicio a la violencia dels homes que maltracten les dones obre una porta a la prevencio i la intervencio en el camp de la violencia contra les dones. Actualment no disposem de farmacs efectius per al tractament de la violencia contra les dones, pero el desenvolupament de programes d’intervencio psicoterapeutica i de rehabilitacio neuropsicologica marca una via d’esperanca.
Optimal management of hormonal contraceptives after an episode of venous thromboembolism
2019
Optimal management of hormonal contraception in patients with venous thromboembolism (VE) requires an individualized approach considering its potential benefits and complications during and after anticoagulant treatment. Potential benefits include prevention of pregnancy and mitigation of menstrual bleeding that is often worsened after start of anticoagulation therapy. Current evidence suggests that patients may opt for a continuation of (all forms of) hormonal contraception during anticoagulant treatment, provided that they are adequately informed by the treating physicians. Combined oral contraceptives should be stopped before anticoagulant therapy may he discontinued, preferably after th…
Different hormonal response to continuous and intermittent exercise in middle-distance and marathon runners
2008
In order to study the effects of different athletic backgrounds on exercise-induced hormonal responses, serum testosterone, luteinizing hormone, follicle-stimulating hormone and cortisol concentrations were measured before and after intensive continuous and intermittent running in well-trained middle-distance runners (MID) and marathon runners (MAR). They performed two 40-min exercises on a treadmill: a continuous run at an intensity of 80% [tempo run (TR)] and an intermittent run (IR) at an intensity of 100% of the velocity associated with VO(2max). The testosterone response to IR and the cortisol response to TR was higher (P<0.05) in MID compared with MAR. The testosterone response to IR …
"Lights and Shades" of Fertility Preservation in Transgender Men Patients: A Clinical and Pathological Review
2023
Fertility preservation (FP) is becoming a critical issue in transgender men who desire biological offspring in the future. The prevalence of transgender individuals in the United States is increasing, and as a result, the demand for gender-affirming surgeries (GAS) and associated FP techniques is rising. Despite the growing demand, there is currently no personalized approach to FP for transgender men, and the available techniques have limitations that require further investigation. In the present review we carefully examine the existing literature on this topic to highlight the shortcomings of current methods and areas where additional research is needed to advance the field. Hormonal thera…
La hormona antimülleriana : un marcador predictivo en reproducción asistida.
2013
Introducción: la Hormona Antimülleriana es una glicoproteína dimérica miembro de la superfamilia de los transforming growth factor beta, y que es producida por las células de la granulosa de los folículos preantrales y antrales de pequeño tamaño. Su función fundamental en la mujer es la inhibición del crecimiento folicular en las fases iniciales de la foliculogénesis. Los niveles séricos de HAM reflejan el número de folículos primordiales y en desarrollo inicial. Por esto, creemos que resulta ser un poderoso predictor de respuesta ovárica. Material y métodos: el presenta trabajo tiene como objetivo primario evaluar la eficacia de la HAM como análisis predictivo de la reserva ovárica y la re…