Search results for "Hormona"

COMPliance and Arthralgia in Clinical Therapy: the COMPACT trial, assessing the incidence of arthralgia, and compliance within the first year of adju…

2014

5 Office-based Professional Association Gynecologic Oncologists e.V. in Germany (BNGO e.V.), Berlin; 6 Background: This prospective study evaluated the relationship between arthralgia and compliance during the first year of adjuvant anastrozole therapy in postmenopausal women with hormone receptor-positive early breast cancer. Patients and methods: COMPliance and Arthralgia in Clinical Therapy (COMPACT) was an open-label, multicenter, noninterventional study conducted in Germany. Patients had started adjuvant anastrozole 3-6 months before the study start. The primary end points were arthralgia, compliance, and the relationship between compliance and arthralgia, assessed at specific time poi…

Mapping the actions of prolactin in the brain: sexual dimorphism, steroid regulation and the neuroendocrinology of maternal behaviour

2017

El comportamiento maternal cumple la función de proteger a la descendencia en su periodo de mayor vulnerabilidad y asegurar su supervivencia y bienestar. Esta colección de conductas sociales será expresada por la madre exclusivamente durante el periodo postparto, como resultado de la modulación del sustrato neural responsable de la expresión de la conducta social y reproductiva. Los agentes que llevan a cabo dicha modulación para inducir la expresión del comportamiento maternal incluyen, entre otros, señales endocrinas específicas de la gestación y lactancia. Entre éstas destaca la prolactina, hormona adenohipofisaria estrechamente vinculada con la adaptación del organismo a la maternidad. …

Oxygen uptake, acid-base balance and hormonal responses in maximal 300 - 400 m running in child, adolescent and adult athletes

2013

Vilmi, Nikke (2013). Oxygen uptake, acid-base balance and hormonal responses in maximal 300 - 400 m running in child, adolescent and adult athletes. Department of Biology of Physical Activity, University of Jyväskylä, Master's thesis, Science of Sport Coaching and Fitness Testing, 55 pp. The 400 m sprint demands both aerobic and anaerobic energy systems. During the race the acid-base balance of the body is disturbed and that has effects on the oxygen uptake. The purpose of this study was to investigate the oxygen uptake and acid-base balance during and after the maximal anaerobic running test in child (300 m), adolescent (350 m) and adult (400 m) athletes. Furthermore, the aim was also to d…

Maternally‐transferred thyroid hormones and life‐history variation in birds

2022

1. In vertebrates, thyroid hormones (THs) play an important role in the regulation of growth, development, metabolism, photoperiodic responses and migration. Maternally transferred THs are important for normal early-phase embryonic development when embryos are not able to produce endogenous THs. Previous studies have shown that variation in maternal THs within the physiological range can influence offspring phenotype. 2. Given the essential functions of maternal THs in development and metabolism, THs may be a mediator of life-history variation across species. 3. We tested the hypothesis that differences in life histories are associated with differences in maternal TH transfer across species…

Molecular investigation on the etiology of preeclampsia and new strategies for its early diagnosis

2023

Endometrial decidualization is critical for pregnancy establishment and maintenance. This process promotes endometrial remodeling allowing placental cytotrophoblasts (CTBs) invasion up to an appropriate depth to form the maternal-fetal interface. A shallow CTBs invasion compromises healthy pregnancy and it is associated with the development of severe preeclampsia (sPE). Our working hypothesis is that defective decidualization impairs the adaptation of the maternal “soil” ─the decidua─ to be invaded by CTBs and plays a pivotal role in the etiology of sPE. Previously, we have demonstrated the existence of an in vitro defective decidualization of endometrial stromal cells isolated from women w…

Trasplante autólogo de médula ósea en ovario en mujeres con baja reserva ovárica y fallo ovárico precoz, para rejuvenecimiento del nicho ovárico y fa…

2020

Como consecuencia del retraso de la maternidad a causa de las tendencias sociales actuales, existe una disminución de la calidad y cantidad de ovocitos disponibles. Al problema fisiológico de la edad materna avanzada, se suman dos patologías, que asocian una baja reserva ovárica, en pacientes jóvenes: baja respuesta ovárica (del inglés, poor ovarian response, o POR), e insuficiencia ovárica prematura(del inglés, premature ovarian insufficiency o POI). Numerosos protocolos de estimulación ovárica han sido desarrollados, sin ser efectivos, siendo en la mayoría de los casos, la única opción para estas pacientes la donación de ovocitos/embriones. Varios trabajos de investigación han descrito la…

Long-term outcome of antiandrogen monotherapy in advanced prostate carcinoma. Twelve-year’s results of a phase II study.

2003

OBJECTIVE: To present the long-term outcome of patients with locally advanced or metastatic prostate carcinoma treated by first-line antiandrogen monotherapy. PATIENTS AND METHODS: From 1983 to 1990, 41 patients with advanced prostate carcinoma were treated with flutamide monotherapy until progression or the appearance of toxicity. Twenty-five patients (61%) had T3-T4N0M0 and 16 (39%) T2-4N0-3M1 prostate carcinoma. Consensus criteria were adopted to evaluate the response. Plasma testosterone and sexual function were recorded for the first 3 years. RESULTS: Flutamide was administered for up to 147 months; seven patients (17%) interrupted the treatment because of toxicity. There was an object…

Growth-associated variation in body size, hormonal status, physical performance characteristics and perceptual-motor skills in Finnish young soccer p…

2013

Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor

2020

Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …

A 10-Week Block of Combined High-Intensity Endurance and Strength Training Produced Similar Changes in Dynamic Strength, Body Composition, and Serum …

2020

Purpose: To examine the potential sex differences in adaptations to combined endurance and strength training in recreationally endurance trained (eumenorrheic) women (n = 9) and men (n = 10). Methods: Isometric (ISOMmax) and dynamic bilateral leg press (1RM), countermovement jump (CMJ), running performance (3,000 m time trial), lean mass and body fat % (LEAN and FAT% determined by dual X-ray absorptiometry) as well as serum testosterone and cortisol (TES and COR, respectively, measured using hormone-specific immunoassay kits) were examined before a control period and pre, mid, and post a supervised 10-week combined high-intensity interval endurance training (4 × 4 min intervals and 3 × 3 × …