Search results for "Hormonal"
showing 6 items of 136 documents
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Efectos de un programa de intervención psicoeducativa en la calidad de vida de los/las pacientes durante sus tratamientos de Reproducción Asistida
2021
El término Infertilidad Humana se refiere a la no consecución del embarazo después de 12 meses de mantener relaciones sexuales sin el uso de métodos anticonceptivos. Ha sido reconocido por la Organización Mundial de la Salud (OMS) como un problema de salud pública a nivel global, y aunque existe un alto número de personas con infertilidad, aproximadamente tan sólo la mitad de estas personas buscan tratamientos médicos para lograr concebir. Las personas que se someten a Tratamientos de Reproducción Asistida (TRA) pasan por una serie de etapas en las que sufren distintos tipos de cambios, tanto en su estado físico como emocional. La literatura muestra que durante los tratamientos las mujeres …
Effects of hormonal contraceptives on physical performance and body composition
2016
The purpose of the present study was to examine the effects of hormonal contraceptive use on neuromuscular, cardiorespiratory and body composition adaptations following combined strength and endurance training period. Methods. Nineteen recreationally active women; 11 who had at least one year of hormonal contraceptive use (age 294 yr; BMI 212 kg/m2; VO2max 444 ml/kg/min) and 8 who had never used hormonal contraceptives (age 315 yr; BMI 222 kg/m2; VO2max 414 ml/kg/min) participated in the present study of combined strength and endurance training for 10 weeks. Training consisted of two maximal and explosive strength training sessions, and two high-intensity interval training sessions pe…
Neuromuscular Performance and Hormonal Profile During Military Training and Subsequent Recovery Period
2019
Introduction Military training loads may induce different physiological responses in garrison and field training and only a little is known about how short-time recovery, lasting a few days, affects neuromuscular fitness and hormonal profile. This study aimed to investigate the effects of garrison and field military service on neuromuscular performance and hormonal profile and to evaluate the effects of a 3-day recovery on those factors. Methods Twenty healthy male soldiers (20 ± 1 years) participated in the study, which consisted of 4 days of garrison training [days (D) 1–4] and 7 days of military field training (Days 5–12) followed by a 3-day recovery period (Day 15). Serum hormone concen…
Wpływ korekty płci na poczucie jakości życia mężczyzn transpłciowych – wyniki badania pilotażowego oraz przyczynek do dalszych badań
2017
Badanie pilotażowe miało na celu weryfikację doniesień naukowych mówiących o dobrym funkcjonowaniu osób transpłciowych. Na tej podstawie starano się porównać poczucie jakości życia mężczyzn transpłciowych z cispłciowymi mężczyznami heteroseksualnymi, homoseksualnymi i biseksualnymi a także zweryfikować role terapii hormonalnej i operacyjnej korekty płci jako potencjalnych predyktorów poczucia jakości życia mężczyzn transpłciowych. Cispłciowi mężczyźni heteroseksualni wykazywali się istotnie wyższym poczuciem jakości życia w stosunku do członków społeczności LGBTQ (mężczyzn transpłciowych, cispłciowych męż - czyzn homoseksualnych i biseksualnych). Orientacja seksualna mężczyzn transpłciowych…
Associations of Sex Hormones and Hormonal Status With Arterial Stiffness in a Female Sample From Reproductive Years to Menopause
2021
ObjectiveLoss of sex hormones has been suggested to underlie menopause-associated increment in cardiovascular risk. We investigated associations of sex hormones with arterial stiffness in 19–58-years-old women. We also studied associations of specific hormonal stages, including natural menstrual cycle, cycle with combined oral contraceptives (COC) and menopausal status with or without hormone therapy (HT), with arterial stiffness.MethodsThis study includes repeated measurements of 65 healthy women representing reproductive (n=16 natural, n=10 COC-users) and menopause (n=5 perimenopausal, n=26 postmenopausal, n=8 HT-users) stages. Arterial stiffness outcomes were aortic pulse wave velocity (…