Search results for "HuR"

Use of Biologics to Treat Relapsing and/or Refractory Eosinophilic Granulomatosis With Polyangiitis: Data From a European Collaborative Study.

2021

OBJECTIVE To describe the efficacy and safety of biologics for the treatment of eosinophilic granulomatosis with polyangiitis (EGPA). METHODS A retrospective European collaborative study was conducted in patients with EGPA who received treatment with biologics for refractory and/or relapsing disease. RESULTS Among the 147 patients with EGPA included in the study, 63 received rituximab (RTX), 51 received mepolizumab (MEPO), and 33 received omalizumab (OMA). At the time of inclusion, the median Birmingham Vasculitis Activity Score (BVAS) was 8.5 (interquartile range [IQR] 5-13) in the RTX group, while the median BVAS in the OMA group was 2 (IQR 1-4.5) and the median BVAS in the MEPO group was…

Temporal Structure of Human Gaze Dynamics Is Invariant During Free Viewing.

2015

We investigate the dynamic structure of human gaze and present an experimental study of the frequency components of the change in gaze position over time during free viewing of computer-generated fractal images. We show that changes in gaze position are scale-invariant in time with statistical properties that are characteristic of a random walk process. We quantify and track changes in the temporal structure using a well-defined scaling parameter called the Hurst exponent, H. We find H is robust regardless of the spatial complexity generated by the fractal images. In addition, we find the Hurst exponent is invariant across all participants, including those with distinct changes to higher or…

Scheie syndrome: enzyme replacement therapy does not prevent progression of cervical myelopathy due to spinal cord compression.

2009

Hurler-Scheie syndrome is caused by alpha-l-iduronidase deficiency. Enzyme replacement therapy (ERT) can improve physical capacity and reduces organomegaly. However, the effect on bradytrophic connective tissue is limited. As intravenously administered enzyme cannot cross the blood-brain barrier, the therapy of choice for the more severe Hurler syndrome is haematopoietic stem cell transplantation (HCT). In the more attenuated Scheie syndrome, neurological impairment is less severe; therefore, ERT may be appropriate to treat these patients. Information on long-term outcome in Scheie patients undergoing ERT is scarce. We report a 38-year-old female Scheie patient who has been on ERT for 8 yea…

Book Review: The Ugandan Churches and the Political Centre, edited by Paddy Musana, Angus Crichton and Caroline Howell

2018

Shared midgut binding sites for Cry1A.105, Cry1Aa, Cry1Ab, Cry1Ac and Cry1Fa proteins from Bacillus thuringiensis in two important corn pests, Ostrin…

2013

First generation of insect-protected transgenic corn (Bt-corn) was based on the expression of Cry1Ab or Cry1Fa proteins. Currently, the trend is the combination of two or more genes expressing proteins that bind to different targets. In addition to broadening the spectrum of action, this strategy helps to delay the evolution of resistance in exposed insect populations. One of such examples is the combination of Cry1A.105 with Cry1Fa and Cry2Ab to control O. nubilalis and S. frugiperda. Cry1A.105 is a chimeric protein with domains I and II and the C-terminal half of the protein from Cry1Ac, and domain III almost identical to Cry1Fa. The aim of the present study was to determine whether the c…

An improvement of a bound of Green

2012

A p-group G of order pn (p prime, n ≥ 1) satisfies a classic Green's bound log p |M(G)| ≤ ½n(n - 1) on the order of the Schur multiplier M(G) of G. Ellis and Wiegold sharpened this restriction, proving that log p |M(G)| ≤ ½(d - 1)(n + m), where |G′| = pm(m ≥ 1) and d is the minimal number of generators of G. The first author has recently shown that log p |M(G)| ≤ ½(n + m - 2)(n - m - 1) + 1, improving not only Green's bound, but several other inequalities on |M(G)| in literature. Our main results deal with estimations with respect to the bound of Ellis and Wiegold.

Characters, bilinear forms and solvable groups

2016

Abstract We prove a number of results about the ordinary and Brauer characters of finite solvable groups in characteristic 2, by defining and using the concept of the extended nucleus of a real irreducible character. In particular we show that the Isaacs canonical lift of a real irreducible Brauer character has Frobenius–Schur indicator +1. We also show that the principal indecomposable module corresponding to a real irreducible Brauer character affords a quadratic geometry if and only if each extended nucleus is a split extension of a nucleus.

Irreducibility of Hurwitz spaces of coverings with one special fiber

2006

Abstract Let Y be a smooth, projective complex curve of genus g ⩾ 1. Let d be an integer ⩾ 3, let e = {e1, e2,..., er} be a partition of d and let | e | = Σi=1r(ei − 1). In this paper we study the Hurwitz spaces which parametrize coverings of degree d of Y branched in n points of which n − 1 are points of simple ramification and one is a special point whose local monodromy has cyclic type e and furthermore the coverings have full monodromy group Sd. We prove the irreducibility of these Hurwitz spaces when n − 1 + | e | ⩾ 2d, thus generalizing a result of Graber, Harris and Starr [A note on Hurwitz schemes of covers of a positive genus curve, Preprint, math. AG/0205056].

On Hurwitz spaces of coverings with one special fiber

2009

Let X X' Y be a covering of smooth, projective complex curves such that p is a degree 2 etale covering and f is a degree d covering, with monodromy group Sd, branched in n + 1 points one of which is a special point whose local monodromy has cycle type given by the partition e = (e1,...,er) of d. We study such coverings whose monodromy group is either W(Bd) or wN(W(Bd))(G1)w-1 for some w in W(Bd), where W(Bd) is the Weyl group of type Bd, G1 is the subgroup of W(Bd) generated by reflections with respect to the long roots ei - ej and N(W(Bd))(G1) is the normalizer of G1. We prove that in both cases the corresponding Hurwitz spaces are not connected and hence are not irreducible. In fact, we s…

A presentation and a representation of the Held group

1996

In this note we give a brief description of a new presentation of the Held group, which is deduced only from the original work of D. Held in 1969, who shows that a finite simple group, having the same centralizer of a 2-central involution as in the Mathieu group M24, is M24, L5(2) or a group of order 4.030.387.200. The first complete uniqueness proof for the latter case was given by L. Soicher in 1991. The generators and relations occurring here are easy to verify by a simple Todd–Coxeter algorithm. It is an easy task to get a new uniqueness and existence proof of the Held group from this result. Also basic facts like the Schur Multiplier or the automorphism group of the Held group follow f…