Search results for "Hunting"
showing 10 items of 114 documents
Best Friends Forever? Modeling the Mechanisms of Friendship Network Formation
2020
The formation of friendships and alliances is a ubiquitous feature of human life, and likely a crucial component of the cooperative hunting and child-rearing practices that helped our early hominin ancestors survive. Research on contemporary human beings typically finds that strong-tie social networks are fairly small, and reveals a high degree of physical (e.g., age) and social-structural (e.g., educational attainment) homophily. Yet, existing work all too often underestimates, or even ignores, the importance of abstract, symbolic homophily (such as shared identities or worldviews) as a driver of friendship formation. Here we employ agent-based modeling to identify the optimal variable wei…
J14 Mediterranean Diet And Nutritional Composition Of Patients With Huntington's Disease. Spanish Multicenter Study Of The European Group For Hunting…
2014
Background The impact of a diet is well known in human health. Intake of food groups (fruits and ‘uts, vegetables, legumes, olive oil, whole grains, fish and wine) in the traditional Mediterranean Diet (MeDi) and high MeDi adherence have been associated with lower incidence of chronic diseases and slower cognitive decline, but the relationship between MeDi adherence and nutritional composition has not been reported. Objectives To describe MeDi and nutritional composition in patients with HD. Methods Spanish multicenter, cross-sectional study (EHDN). To assess MeDi we used a 3-days dietary record. Food groups, macro and micronutrients and energy intake information were obtained using the sof…
Factors Associated with Low Body Mass Index in Huntington's Disease: A Spanish Multicenter Study of the European Huntington's Disease Registry
2016
Background Patients with Huntington's disease (HD) are at risk for body weight loss and increased risk for institutionalization, morbidity, and mortality. The aim of this study was to determine the factors associated with low body mass index (BMI) in patients with HD. Methods In this national, observational, cross-sectional study of the European Huntington's Disease Network, the frequency of food consumption, calories, and nutrient intake in patients with HD was assessed using questionnaires validated for the Spanish population and were calculated using the software package Alimentacion and Salud (Diet and Health), version 2.0. Nutritional status was estimated using the BMI, and disease sev…
Depression and Movement Disorders
2012
I06 Dysphagia In Huntington`s Disease: A Multicenter Study
2014
Background Dysphagia is a common complication of neurogenerative disorders, and a leading cause of death due to aspiration pneumonia. Little is known about the frequency and the characteristics of dysphagia in HD. Well-balanced strategies for treatment and prevention of dysphagia in HD are lacking. Objetives To determine the prevalence of dysphagia in HD. Methods National, multicenter, observational, cross-sectional Study (Spanish EHDN). Dysphagia was assessed using the questionnaire EAT-10 (eating assessment tool), caregiver burden using the SumaCare, functional capacity using the TFC score, disease severity using the Unified HD Rating Scale (UHDRS), psyquiatric status (PBA-s), nutritional…
Letter: Cerebrospinal Fluid Shunting Improves Long-Term Quality of Life in Idiopathic Normal Pressure Hydrocephalus.
2020
Diagnosis, treatment, and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus
2007
To the Editor:We read with interest the article by McGirt et al. (9) entitled“Diagnosis, Treatment, and Analysis of Long-term Outcomes inIdiopathic Normal Pressure Hydrocephalus.” The authors con-clude that gait impairment is the primary symptom that inde-pendently predicted improvement after shunting. The studyincluded 132 patients, 129 (98%) of whom had gait impairmentas a feature. We would like to comment on this particular selec-tion criterion, as well as improvements in the Mini Mental StateExamination (MMSE) as the sole measure of postoperative cog-nitive improvement.One of the inclusion criteria for this study was presentationwith two or more features of the classic triad. Thus, the …
Beyond Hunting Camps: Early Holocene Occupations in High Cantabrian Mountains (Spain)
1998
En la comunicación se presentan los resultados de las excavaciones en el abrigo de La Calvera (Camaleño, Cantabria) incluyendo un conjunto de nuevas dataciones radiocarbónicas y se hace una reflexión sobre la ocupación de las montañas cantábricas al comienzo del Holoceno. In the communication the results of the excavations in La Calvera rock shelter (Camaleño, Cantabria) are presented, including a set of new radiocarbonic dates and a reflection is made on the occupation of the Cantabrian mountains at the beginning of the Holocene.
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…