Search results for "Hunting"
showing 10 items of 114 documents
0204: Proteome-wide sex-related differences in response to mouse thoracic aortic constriction: molecular bio-signature of failing hearts
2014
Chronic pressure overload (PO) induces pathological left ventricular hypertrophy (LVH) leading to congestive heart failure (HF). Over-expression of FKBP12.6 (FK506 binding protein (K)) in mice should prevent Ca2+-leak during diastole and may improve overall cardiac function. In order to decipher molecular mechanisms involved in thoracic aortic constriction (TAC)-induced cardiac remodelling and the influence of gender and genotype, we performed a proteomic analysis using 2D-DIGE, mass spectrometry and bioinformatics techniques to identify alterations in characteristic biological networks. Wild type (W) and K mice of both genders underwent TAC. Thirty days post-TAC, the altered cardiac remode…
The Role of Low Complexity Regions in Protein Interaction Modes: An Illustration in Huntingtin
2021
Low complexity regions (LCRs) are very frequent in protein sequences, generally having a lower propensity to form structured domains and tending to be much less evolutionarily conserved than globular domains. Their higher abundance in eukaryotes and in species with more cellular types agrees with a growing number of reports on their function in protein interactions regulated by post-translational modifications. LCRs facilitate the increase of regulatory and network complexity required with the emergence of organisms with more complex tissue distribution and development. Although the low conservation and structural flexibility of LCRs complicate their study, evolutionary studies of proteins …
Common Factors in Neurodegeneration: A Meta-Study Revealing Shared Patterns on a Multi-Omics Scale
2020
Neurodegenerative diseases such as Alzheimer&rsquo
Un 'halcón' paradigmático
2007
Flanking regions determine the structure of the poly-glutamine homo- repeat in huntingtin through mechanisms common among glutamine-rich human protei…
2020
International audience; The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich region (PRR), which promote and inhibit the aggregation propensity of the protein, respectively, by poorly understood mechanisms. Based on experimental data obtained from site-specifically labeled NMR samples, we derived an ensemble model of httex1 that identified both flanking regions as opposing poly-Q secondary structure promoters. While N17 triggers helicity through a promiscuous hydrogen bond network involving the side chains of the first glutamines in the poly-Q tract, the PRR prom…
Cancer and central nervous system disorders: protocol for an umbrella review of systematic reviews and updated meta-analyses of observational studies
2017
[Background] The objective of this study will be to synthesize the epidemiological evidence and evaluate the validity of the associations between central nervous system disorders and the risk of developing or dying from cancer.
Priority areas for the conservation of Atlantic forest large mammals
2009
Large mammal faunas in tropical forest landscapes are widely affected by habitat fragmentation and hunting, yet the environmental determinants of their patterns of abundance remain poorly understood at large spatial scales. We analysed population abundance and biomass of 31 species of medium to large-bodied mammal species at 38 Atlantic forest sites (including three islands, 26 forest fragments and six continuous forest sites) as related to forest type, level of hunting pressure and forest fragment size using ANCOVAs. We also derived a novel measure of mammal conservation importance for each site based on a "Mammalian Conservation Priority index" (MPi) which incorporates information on spec…
Roots of the Savage Mind. Apophenia and Imagination as Cognitive Process
2009
l'articolo studia il ruolo cognitivo dell'immaginario con particolare riferimento alle culture di caccia e raccolta e al problema della costruzione simbolica del paesaggio
UN INTERVENTO INTEGRATO TRA TERAPIA FARMACOLOGICA E NON FARMACOLOGICA IN UN CASO DI COREA DI HUNTINGTON: PRIMI RISULTATI
2016
Il lavoro che presentiamo riguarda un intervento integrato effettuato attraverso terapia farmacologica e non farmacologica (musicoterapia) realizzato all’interno del centro U.V.A. N°6 dell’A.O.U.P. del Policlino “P. Giaccone” di Palermo con una paziente affetta da Corea di Huntington, di 59 anni, seguita precedentemente dall’ambulatorio di neurologia della stessa azienda. La paziente si è ripresenta nel nostro centro uva nel novembre del 2015 a causa di un peggioramento delle turbe dell’equilibrio, della coordinazione motoria, dei movimenti coreici, dei deficit di memoria e del tono dell’umore in senso depressivo, facile irritabilità e labilità emotiva; in terapia con trifluoperazina diclor…
“Tirare al selvatico”: modalità. Una voce del Vocabolario-Atlante delle pratiche venatorie siciliane .
2020
Viene presentato un saggio di voce del "Vocabolario-atlante delle pratiche venatorie siciliane", secondo il modello elaborato in seno all’Atlante Linguistico della Sicilia (ALS). Con una nuova messe di dati e tenendo conto del modello di voce elaborato per il Vocabolario-atlante, in questo contributo, che vuole essere un ideale ampliamento della voce "sparari" pubblicata nel 1980 da Giovanni Ruffino in questo stesso Bollettino, sono prese in esame le numerose locuzioni venatorie relative alle modalità di ‘tirare al selvatico’, concetto che nel lessico venatorio siciliano è generalmente espresso con il tipo lessicale "sparari". A sample of the entry of the "Vocabolario-atlante delle pratiche…