Search results for "Hybrid System"
showing 10 items of 98 documents
RPGR ORF15 isoform co-localizes with RPGRIP1 at centrioles and basal bodies and interacts with nucleophosmin
2005
The ORF15 isoform of RPGR (RPGR(ORF15)) and RPGR interacting protein 1 (RPGRIP1) are mutated in a variety of retinal dystrophies but their functions are poorly understood. Here, we show that in cultured mammalian cells both RPGR(ORF15) and RPGRIP1 localize to centrioles. These localizations are resistant to the microtubule destabilizing drug nocodazole and persist throughout the cell cycle. RPGR and RPGRIP1 also co-localize at basal bodies in cells with primary cilia. The C-terminal (C2) domain of RPGR(ORF15) (ORF15(C2)) is highly conserved across 13 mammalian species, suggesting that it is a functionally important domain. Using matrix-assisted laser desorption ionization time-of-flight mas…
A hybrid architecture for autonomous agents
1997
A new hybrid approach for autonomous agents is described. The approach integrates in a principled way the functional and the behavioral approaches of agent design. The integration is based on the introduction of a conceptual space representation that links the subsymbolic level, which is a repository of reactive modules, with the symbolic level, in which rich symbolic descriptions of the agent environment take place. Results are reported obtained by an experimental implementation of the agent.
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle
2002
Deaf-blindness in three distinct genetic forms of Usher type I syndrome (USH1) is caused by defects in myosin VIIa, harmonin and cadherin 23. Despite being critical for hearing, the functions of these proteins in the inner ear remain elusive. Here we show that harmonin, a PDZ domain-containing protein, and cadherin 23 are both present in the growing stereocilia and that they bind to each other. Moreover, we demonstrate that harmonin b is an F-actin-bundling protein, which is thus likely to anchor cadherin 23 to the stereocilia microfilaments, thereby identifying a novel anchorage mode of the cadherins to the actin cytoskeleton. Moreover, harmonin b interacts directly with myosin VIIa, and i…
Optimal paths in weighted timed automata
2004
AbstractWe consider the optimal-reachability problem for a timed automaton with respect to a linear cost function which results in a weighted timed automaton. Our solution to this optimization problem consists of reducing it to computing (parametric) shortest paths in a finite weighted directed graph. We call this graph a parametric sub-region graph. It refines the region graph, a standard tool for the analysis of timed automata, by adding the information which is relevant to solving the optimal-reachability problem. We present an algorithm to solve the optimal-reachability problem for weighted timed automata that takes time exponential in O(n(|δ(A)|+|wmax|)), where n is the number of clock…
Deciding reachability for planar multi-polynomial systems
1996
In this paper we investigate the decidability of the reachability problem for planar non-linear hybrid systems. A planar hybrid system has the property that its state space corresponds to the standard Euclidean plane, which is partitioned into a finite number of (polyhedral) regions. To each of these regions is assigned some vector field which governs the dynamical behaviour of the system within this region. We prove the decidability of point to point and region to region reachability problems for planar hybrid systems for the case when trajectories within the regions can be described by polynomials of arbitrary degree.
Impulsively-controlled systems and reverse dwell time: A linear programming approach
2015
We present a receding horizon algorithm that converges to the exact solution in polynomial time for a class of optimal impulse control problems with uniformly distributed impulse instants and governed by so-called reverse dwell time conditions. The cost has two separate terms, one depending on time and the second monotonically decreasing on the state norm. The obtained results have both theoretical and practical relevance. From a theoretical perspective we prove certain geometrical properties of the discrete set of feasible solutions. From a practical standpoint, such properties reduce the computational burden and speed up the search for the optimum thus making the algorithm suitable for th…
Accelerating short read mapping on an FPGA (abstract only)
2012
The explosive growth of short read datasets produced by high throughput DNA sequencing technologies poses a challenge to the mapping of short reads to a reference genome in terms of sensitivity and execution speed. Existing methods often use a restrictive error model for computing the alignments to improve speed, whereas more flexible error models are generally too slow for large-scale applications. Although a number of short read mapping software tools have been proposed, designs based on hardware are relatively rare. In this paper, we present a hybrid system for short read mapping utilizing both software and field programmable gate array (FPGA)-based hardware. The compute intensive semi-g…
Human-centred Assembly: A Case Study for an Anthropocentric Cyber-physical System
2014
Abstract To engineer the factory of the future the paper argues for an anthropocentric cyber-physical reference model that assimilate in an integrated, dynamic, structural and functional way all the required components (i.e. physical, computational and human) of a synthetic hybrid system. This is due to the real need to design large-scale complex systems that accommodate the latest achievements in factory automation where the human is not merely playing a simple and clear role inside the control-loop, but is becoming a composite factor in a highly automated system (“man-in-the-mesh”). The concept is demonstrated by instantiating our anthropocentric cyber-physical reference model in a concre…
Feasibility analysis of a renewable hybrid energy system with producer gas generator fulfilling remote household electricity demand in Southern Norway
2016
Abstract Hybrid energy system is increasingly emerging as an option to produce energy for the remote areas. This paper presented an economic feasibility analysis of a single standalone house operating with a hybrid power plant consisting of a fixed capacity producer gas generator (2 kWe) and other renewable energy sources (Photovoltaic and wind). The National Renewable Energy Laboratory's Hybrid Optimization Model for Electric Renewable (HOMER) was employed which evaluated techno-economic analysis based on the criteria of net present cost and levelized cost of electricity. Taking the site specific daily average solar radiation, average wind speed and load data into account, renewable hybrid…
Performance evaluation of CHCP hybrid seawater desalination plants
2007
There are many ways to improve efficiency and reduce fresh water cost in desalination plants, like the integration of two or more desalination systems into a hybrid mechanical/thermal lay-out. Most common results that could be achieved by hybrid systems are savings in pretreatments, overall cost reduction and significant primary energy savings, especially when cogeneration unit are concerned. In this paper a small size (2000 m 3 /day) thermal desalination system (MEE) is coupled with a single-stage seawater reverse osmosis (SWRO) system; the system is fed by a natural gas (NG) reciprocate engine, where heat is recovered both from exhaust gases and from the cooling jacket water circuit. Tech…