Search results for "Hymecromone"

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Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7

1999

Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Among the glucuronidation reactions of PAH metabolites studied, mono- and diglucuronide formation of benzo[a]pyrene and chrysene-3,6-diphenol showed the highest induction factors in rat liver microsomes. Availability of AHH-1 cells stably expressing UGT1A7 allowed us to study whether this PAH-inducible isoform could catalyze benzo[a]pyrene and chrysene-3,6-diphenol glucuronidation. It was found that UGT1A7 indeed catalyzed mono- and diglucuronide formation of both benzo[a]pyrene and chrysene 3,6-diphenols. V79 cell-expressed rat UGT1A6 also catalyzed these re…

PharmacologyChrysenechemistry.chemical_classificationStereochemistryMetaboliteGlucuronidationPolycyclic aromatic hydrocarbonGlucuronatesTransfectionBiochemistryChrysenesCell LineSubstrate SpecificityKineticschemistry.chemical_compoundPhenolschemistryBenzo(a)pyreneBenzo(a)pyrenepolycyclic compoundsPyrenePhenolsGlucuronosyltransferaseHymecromoneCarcinogenBiochemical Pharmacology

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