Search results for "Hyperexcitability"
showing 4 items of 4 documents
Cannabinoids, TRPV and nitric oxide: the three ring circus of neuronal excitability
2019
Endocannabinoid system is considered a relevant player in the regulation of neuronal excitability, since it contributes to maintaining the balance of the synaptic ionic milieu. Perturbations to bioelectric conductances have been implicated in the pathophysiological processes leading to hyperexcitability and epileptic seizures. Cannabinoid influence on neurosignalling is exerted on classic receptor-mediated mechanisms or on further molecular targets. Among these, transient receptor potential vanilloid (TRPV) are ionic channels modulated by cannabinoids that are involved in the transduction of a plethora of stimuli and trigger fundamental downstream pathways in the post-synaptic site. In this…
Microtubule Dynamics and Neuronal Excitability: Advances on Cytoskeletal Components Implicated in Epileptic Phenomena
2020
AbstractExtensive researches have deepened knowledge on the role of synaptic components in epileptogenesis, but limited attention has been devoted to the potential implication of the cytoskeleton. The study of the development of epilepsy and hyperexcitability states involves molecular, synaptic, and structural alterations of neuronal bioelectric activity. In this paper we aim to explore the neurobiological targets involved in microtubule functioning and cytoskeletal transport, i.e. how dynamic scaffolding of microtubules can influence neuronal morphology and excitability, in order to suggest a potential role for microtubule dynamics in the processes turning a normal neuronal network in a hy…
Abnormal peripheral and central visual processing in migraine
2018
Sound induced flash illusion (SIFI) is an illusory cross modal (audio-visual) phenomenon critically dependent upon excitability of visual cortex. A recent study with SIFI confirmed hyperexcitability of visual cortex in migraine; patients with migraine show abnormality of chromatic perception. Here we explored the relationship between peripheral chromatic and central visual dysfunction in patients with migraine
Ensayo clínico multicéntrico, aleatorizado y enmascarado con topiramato versus placebo para el tratamiento de recién nacidos con encefalopatía hipóxi…
2021
Antecedentes: La encefalopatía hipóxico-isquémica (EHI) perinatal constituye una de de las principales causas de muerte o discapacidad a largo plazo en recién nacidos a término en el mundo occidental, afectando a aproximadamente 1-4 por cada 1000 nacidos vivos y, en consecuencia, a alrededor de 5000-20000 recién nacidos por año en Europa. La hipotermia terapéutica se ha convertido en el tratamiento estándar de la EHI moderada o grave, siendo una terapia segura y eficaz para mejorar el desarrollo neurológico tras un insulto hipóxico-isquémico perinatal. A pesar de la hipotermia y las mejoras en los cuidados intensivos neonatales, el 45-50% de los recién nacidos con EHI moderada o grave muere…