Search results for "Hypotalamu"
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Ethanol releases corticotropic releasing hormone (CRH) from rat hypothalamic explants; role of acetaldehyde
2009
Ethanol activates hypothalamic-pituitary-adrenal (HPA) axis, resulting in adrenocorticotropic hormone (ACTH) glucocorticoid release, and a modification of the response of this axis to other stressors (Lee et al 1999, 2000). To determine the mechanisms responsible for these effects we investigated : 1) whether ethanol was able to release CRH from incubated hypothalamic explants; 2) whether acetaldehyde (ACD), its first metabolite formed in the brain by catalase activity, might play a role in ethanol effects. To this aim, rat hypothalamic explants were incubated with: 1) medium containing ethanol at 150 mg %; 2) different concentrations of ACD (4.4, 13.2, 44, 132 x 10-3 mg%); 3) ethanol plus …
Ethanol stimulates corticotropic releasing hormone (CRH) release from rat hypothalamic explants; role of acetaldehyde
2009
Ethanol is able to activate the hypothalamic-pituitary-adrenal (HPA) axis, and to modify its response to other stressors, releasing adrenocorticotropic hormone (ACTH), and glucocorticoid release, (Lee et al 1999, 2000). In the brain ethanol is diverted by catalase activity into acetaldehyde, which is reported to mediate some of its behavioural and neurochemical effects. (Peana et al 2008, Melis et al 2007) Thus, to clarifìy the mechanisms underlying ethanol activity on the HPA axis we investigated :1) ethanol effect on CRH release from incubated hypothalamic explants; 2) the role of acetaldehyde (ACD), in mediating ethanol activity. To this aim, rat hypothalamic explants were incubated with…