Search results for "Hypothesis"
showing 10 items of 426 documents
Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!
2012
International audience; During brain development, there is a progressive reduction of intracellular chloride associated with a shift in GABA polarity: GABA depolarizes and occasionally excites immature neurons, subsequently hyperpolarizing them at later stages of development. This sequence, which has been observed in a wide range of animal species, brain structures and preparations, is thought to play an important role in activity-dependent formation and modulation of functional circuits. This sequence has also been considerably reinforced recently with new data pointing to an evolutionary preserved rule. In a recent ``Hypothesis and Theory Article,'' the excitatory action of GABA in early …
Content quality assessment and acceptance testing in location‐based services
2006
In this paper, we develop and evaluate an approach to assessing the content quality in a location‐based service (LBS). The proposed approach, instead of assessing the quality in absolute terms such as completeness or accuracy, measures the effect that the imperfection of the content is having on the reliability of that specific LBS. We apply the basic ideas from Software Reliability Engineering (SRE), but develop a modification of SRE, 2‐Branch, in order to separate content quality from other factors, such as positioning imprecision, and to reduce the measurement error. In our experimental study, we first compare 2‐Branch to the standard SRE, after which we experimentally analyze some prope…
Evolution of small prokaryotic genomes
2015
As revealed by genome sequencing, the biology of prokaryotes with reduced genomes is strikingly diverse. These include free-living prokaryotes with ∼800 genes as well as endosymbiotic bacteria with as few as ∼140 genes. Comparative genomics is revealing the evolutionary mechanisms that led to these small genomes. In the case of free-living prokaryotes, natural selection directly favored genome reduction, while in the case of endosymbiotic prokaryotes neutral processes played a more prominent role. However, new experimental data suggest that selective processes may be at operation as well for endosymbiotic prokaryotes at least during the first stages of genome reduction. Endosymbiotic prokar…
Sexual selection and intelligence: Does sexual reproduction drive the evolution of intelligence?
2009
Abstract The basal hypothesis discussed here is the idea that brain architecture could be plastic on a very basal, genetic level due to sexual recombination and reassortment of alleles of genes related to brain development, e.g., neuronal cell adhesion molecules (NCAMs) and others. The role of sexual reassortment leads the study of brain development, species behavior and intelligence to a new version of the so-called “Red Queen Hypothesis”: using the mechanism described here, a kind of runaway selection mechanism seems to arise. Even if NCAMs are almost constant within an individual, they seem to act very differently at the population level and so the role of reassorting polymorphic NCAM- (…
EU income stabilization tool: potential impacts, financial sustainability and farmer’s risk aversion
2021
AbstractThe Income Stabilization Tool, a risk management scheme introduced within the Common Agricultural Policy (CAP) 2014–2020, could help European Union farmers manage the income risks they face. This study assesses the potential impact of implementing this tool through the maximum level of contribution to the fund which determines an indifference to participate in the fund and its financial sustainability. The study relies on an expected utility approach and assesses the variability of loss ratios over time using a sample of Italian hazelnut farms as a case study. The participation depends on the level of farmers' contributions and their degree of risk aversion. However, the CAP public …
Empirical Likelihood-Based ANOVA for Trimmed Means
2016
In this paper, we introduce an alternative to Yuen’s test for the comparison of several population trimmed means. This nonparametric ANOVA type test is based on the empirical likelihood (EL) approach and extends the results for one population trimmed mean from Qin and Tsao (2002). The results of our simulation study indicate that for skewed distributions, with and without variance heterogeneity, Yuen’s test performs better than the new EL ANOVA test for trimmed means with respect to control over the probability of a type I error. This finding is in contrast with our simulation results for the comparison of means, where the EL ANOVA test for means performs better than Welch’s heteroscedastic…
Wormholes and nonsingular spacetimes in Palatinif(R)gravity
2015
We reconsider the problem of $f(R)$ theories of gravity coupled to Born-Infeld theory of electrodynamics formulated in a Palatini approach, where metric and connection are independent fields. By studying electrovacuum configurations in a static and spherically symmetric space-time, we find solutions which reduce to their Reissner-Nordstr\"om counterparts at large distances but undergo important non-perturbative modifications close to the center. Our new analysis reveals that the point-like singularity is replaced by a finite-size wormhole structure, which provides a geodesically complete and thus nonsingular space-time, despite the existence of curvature divergences at the wormhole throat. …
Renormalization group improved black hole spacetimes
2000
We study the quantum gravitational effects in spherically symmetric black hole spacetimes. The effective quantum spacetime felt by a point-like test mass is constructed by ``renormalization group improving'' the Schwarzschild metric. The key ingredient is the running Newton constant which is obtained from the exact evolution equation for the effective average action. The conformal structure of the quantum spacetime depends on its ADM-mass M and it is similar to that of the classical Reissner-Nordstrom black hole. For M larger than, equal to, and smaller than a certain critical mass $M_{\rm cr}$ the spacetime has two, one and no horizon(s), respectively. Its Hawking temperature, specific hea…
PRIME NUMBERS, QUANTUM FIELD THEORY AND THE GOLDBACH CONJECTURE
2012
Motivated by the Goldbach conjecture in Number Theory and the abelian bosonization mechanism on a cylindrical two-dimensional spacetime we study the reconstruction of a real scalar field as a product of two real fermion (so-called \textit{prime}) fields whose Fourier expansion exclusively contains prime modes. We undertake the canonical quantization of such prime fields and construct the corresponding Fock space by introducing creation operators $b_{p}^{\dag}$ --labeled by prime numbers $p$-- acting on the vacuum. The analysis of our model, based on the standard rules of quantum field theory and the assumption of the Riemann hypothesis, allow us to prove that the theory is not renormalizabl…
Estimating the Number of Changepoints in Segmented Regression Models: Comparative Study and Application
2020
This paper deals with the problem of selecting the number of changepoints in segmented regression models. The aim is to review selection criteria, namely information criteria and hypothesis testing, and to propose a novel application in the context of students' careers in higher education. The performance of the selection criteria is assessed through simulation studies. Furthermore, we investigate the relationship between University students' performance and one of its main determinants, finding out that this relationship is actually broken-line.