Search results for "I.7"
showing 10 items of 44 documents
Sphingolipids and Inositol Phosphates Regulate the Tau Protein Phosphorylation Status in Humanized Yeast
2020
Hyperphosphorylation of protein tau is a hallmark of Alzheimer’s disease (AD). Changes in energy and lipid metabolism have been correlated with the late onset of this neurological disorder. However, it is uncertain if metabolic dysregulation is a consequence of AD or one of the initiating factors of AD pathophysiology. Also, it is unclear whether variations in lipid metabolism regulate the phosphorylation state of tau. Here, we show that in humanized yeast, tau hyperphosphorylation is stimulated by glucose starvation in coincidence with the downregulation of Pho85, the yeast ortholog of CDK5. Changes in inositol phosphate (IP) signaling, which has a central role in energy metabolism, altere…
Hypocellularity in the murine model for Down Syndrome Ts65Dn is not affected by adult neurogenesis
2016
Down syndrome (DS) is caused by the presence of an extra copy of the chromosome 21 and it is the most common aneuploidy producing intellectual disability. Neural mechanisms underlying this alteration may include defects in the formation of neuronal networks, information processing and brain plasticity. The murine model for DS, Ts65Dn, presents reduced adult neurogenesis. This reduction has been suggested to underlie the hypocellularity of the hippocampus as well as the deficit in olfactory learning in the Ts65Dn mice. Similar alterations have also been observed in individuals with DS. To determine whether the impairment in adult neurogenesis is, in fact, responsible for the hypocellularity …
Clinical and Immunohistochemical epithelial profile of non-healing chronic traumatic ulcers
2020
Background: Chronic wounds were previously related to cancer. Chronic Traumatic Ulcers (CTU) are lesions caused by chronic mechanical irritation (CMI) frequently diagnosed in Oral Medicine. Although these conditions may re-flect a benign nature, some authors have proposed its relationship with malignant transformation. Currently, there are scarce investigations that evaluate biomarkers within CTU. The aim of this study was to evaluate cell differentiation and proliferation biomarkers patterns of CTU and OSCC through recognized markers such as cytokeratin 19 and Ki67 and correlate it with clinical features of both groups of patients. Material and Methods: A Cross-sectional study of adult pat…
Energy management of multi-carrier smart buildings for integrating local renewable energy systems
2016
The proposed paper aims at defining a Building Management System (BMS) able to control energy flows inside a smart building integrated with various energy networks and Renewable Energy Resources (RES). The smart building envisaged in this work interacts with different energy carriers and is equipped with cogeneration and RES systems, as well as storage devices, which enable a certain degree of flexibility in the energy usage. The smart building is modelled as a multi-carrier hub, by defining the graphical and mathematical model of the building system. Moreover, the control criteria of the BMS are explained and the implementation of the BMS itself is depicted, along with some early results. …
Difference in Ki67 and thymidylate synthase expression in primary tumour compared with metastatic nodes in breast cancer patients.
2005
Breast cancer is a heterogeneous disease, so therapeutic predictive biological markers need to be identified. To date an accurate evaluation of predictive markers is mainly done at the primary site; however, the main goal of adjuvant therapy for breast cancer is the control of micrometastases. The aim of this study is to assess as therapeutic and/or prognostic marker, the proliferation status of primary tumors and involved nodes as measured by Ki67 and thymidylate synthase (TS) expression, in 30 breast cancer node positive patients. TS is the main target of 5-fluorouracil (5-FU) activity, and its overexpression is one of the mechanisms of 5-FU drug resistance; however, in some studies its a…
The evaluation of changes in maxillofacial bones using cone beam tomography in acromegaly
2022
BACKGROUND: The aim of the study was to evaluate the changes in craniofacial dimensions of newly diagnosed and untreated acromegaly patients, patients with non-functional pituitary adenoma and healthy individuals on Cone Beam Computed Tomography (CBCT). MATERIAL AND METHODS: 50 newly diagnosed acromegaly patients who did not receive any treatment for acromegaly were included in the study (Group A). Twenty patients with nonfunctional pituitary adenoma (Group B) and 30 healthy individuals were included (Group C). Linear, angular and volumetric measurements were performed. RESULTS: Mandibular length showed significant difference in acromegaly patients, and maxillar length statistically signifi…
A Novel Symmetrical Boost Modulation Method for qZS-based CHB Inverters
2020
Quasi-Z-source cascaded H-bridge (qZS-CHB) inverters are arising as an innovation in the field of the electrical conversion for PV applications. This type of converters inherit the advantages of multilevel inverters and single-stage configuration. In this context, this paper proposes a novel symmetrical boost modulation strategy for qZS CHB multilevel inverters to increase the performance in terms of voltage stresses and power quality. The novelty lies in the adoption of a different concept to generate the shoot-through states compared to the traditional methods. Simulation analysis in a grid connected application to evaluate the benefits of this boost method is performed in the MATLAB/PLEC…
A comparison of different DC-DC converters for energy storage management in nearly-Zero Energy Buildings
2020
In the recent years, there has been a notable interest towards renewable sources, energy saving and efficiency optimization, in order to reduce the damages brought by fine dust and greenhouse gases in terms of safety, health and environmental protection. In the building sector renewable sources and energy efficiency optimization are leading to a large scale employment of nearly-Zero Energy Buildings (n-ZEBs), meaning that the balance between produced and required energy is negligible. For a proper n-ZEB implementation, a power system architecture has to be accurately designed, according to the existing renewable sources, loads and storage systems. In this paper, an investigation on differen…
Experimental Characterization of a Double Receiver Dynamic Wireless Charging System
2020
The aim of this work is the characterization of a dynamic wireless charging system low power prototype and the validation of a simplified mathematical model of the employed double D coils. The difference between a single receiver and a dual receiver system is also shown, highlighting how the last one can significantly reduce the costs of the charging infrastructure.
Modelling, simulation and characterization of a supercapacitor
2020
In the last decade, the issue of air pollution or the reduction of CO2 emissions has become of extreme interest both for civil society and then for the industrial and scientific research world. For this reason, the scientific research on automotive is called to answer with increasingly innovative solutions. One of the principal subjects are the storage and the utilization of the electric energy for electrical and hybrid vehicles. Nowadays, supercapacitors are getting more and more attention because of their characteristics that allow them to be a bridge between electrolytic capacitors and batteries in several application such as bust-mode energy delivery, regenerative breaks and so on. The …