Search results for "I1"
showing 10 items of 74 documents
Unvolvement of calcium signaling and MAP kinases in lipid taste perception
2013
In this work, we demonstrate that stromal interaction molecule 1 (STIM1), a sensor of Ca2+ depletion in the endoplasmic reticulum, mediates fatty acid–induced Ca2+ signaling in the mouse tongue and fat preference. We showed that linoleic acid (LA) induced the production of arachidonic acid (AA) and lysophosphatidylcholine (Lyso-PC) by activating multiple phospholipase A2 isoforms via CD36. This activation triggered Ca2+ influx in lingual CD36-positive taste bud cells (TBCs) purified from mouse CVP. LA also induced the production of Ca2+ influx factor (CIF). STIM1 was found to regulate LA-induced CIF production and the opening of store-operated Ca2+ (SOC) channels. Furthermore, CD36-positive…
The long-term consequences of the global 1918 influenza pandemic: A systematic analysis of 117 IPUMS international census data sets
2017
Several country-level studies, including a prominent one for the United States, have identified long-term effects of in-utero exposure to the 1918 influenza pandemic (also known as the Spanish Flu) on economic outcomes in adulthood. In-utero conditions are theoretically linked to adult health and socioeconomic status through the fetal origins or Barker hypothesis. Historical exposure to the Spanish Flu provides a natural experiment to test this hypothesis. Although the Spanish Flu was a global phenomenon, with around 500 million people infected worldwide, there exists no comprehensive global study on its long-term economic effects. We attempt to close this gap by systematically analyzing 11…
Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.
2012
Leber hereditary optic neuropathy (LHON) is a mitochondrially inherited form of visual dysfunction caused by mutations in several genes encoding subunits of the mitochondrial respiratory NADH-ubiquinone oxidoreductase complex (complex I). Development of gene therapies for LHON has been impeded by genetic heterogeneity and the need to deliver therapies to the mitochondria of retinal ganglion cells (RGCs), the cells primarily affected in LHON. The therapy under development entails intraocular injection of a nuclear yeast gene NADH-quinone oxidoreductase (NDI1) that encodes a single subunit complex I equivalent and as such is mutation independent. NDI1 is imported into mitochondria due to an e…
"Decay Phase-Space Volume of Partial Waves" of "Light isovector resonances in $\pi^- p \to \pi^-\pi^-\pi^+ p$ at 190 GeV/${\it c}$"
2018
Decay phase-space volume $I_{aa}$ for the 14 selected partial waves as a function of $m_{3\pi}$, normalized such that $I_{aa}(m_{3\pi} = 2.5~\text{GeV}/c^2) = 1$. The wave index $a$ represents the quantum numbers that uniquely define the partial wave. The quantum numbers are given by the shorthand notation $J^{PC} M^\varepsilon [$isobar$] \pi L$. We use this notation to label the decay phase-space volume in the column headers. The labels are identical to the ones used in the column headers of the table of the transition amplitudes. $I_{aa}$ is calculated using Monte Carlo integration techniques for fixed $m_{3\pi}$ values, which are given in the first column, in the range from 0.5 to 2.5 Ge…
"Transition Amplitudes" of "Light isovector resonances in $\pi^- p \to \pi^-\pi^-\pi^+ p$ at 190 GeV/${\it c}$"
2018
Real and imaginary parts of the normalized transition amplitudes $\mathcal{T}_a$ of the 14 selected partial waves in the 1100 $(m_{3\pi}, t')$ cells (see Eq. (12) in the paper). The wave index $a$ represents the quantum numbers that uniquely define the partial wave. The quantum numbers are given by the shorthand notation $J^{PC} M^\varepsilon [$isobar$] \pi L$. We use this notation to label the transition amplitudes in the column headers. The $m_{3\pi}$ values that are given in the first column correspond to the bin centers. Each of the 100 $m_{3\pi}$ bins is 20 MeV/$c^2$ wide. Since the 11 $t'$ bins are non-equidistant, the lower and upper bounds of each $t'$ bin are given in the column he…
Heterogeneity in general practitioners’ preferences for quality improvement programs: a choice experiment and policy simulation in France
2016
International audience; Despite increasing popularity, quality improvement programs (QIP) have had modest and variable impacts on enhancing the quality of physician practice. We investigate the heterogeneity of physicians’ preferences as a potential explanation of these mixed results in France, where the national voluntary QIP – the CAPI – has been cancelled due to its unpopularity. We rely on a discrete choice experiment to elicit heterogeneity in physicians’ preferences for the financial and non-financial components of QIP. Using mixed and latent class logit models, results show that the two models should be used in concert to shed light on different aspects of the heterogeneity in prefer…
Ruby paplašinājums ērtai tulkojumu pārvaldei
2017
Kvalifikācijas darbā izstrādātais Ruby paplašinājums Kakimasu (japāņu valodā rakstīt) ir paredzēts ātrai un ērtai projekta tulkojumu pārvaldei. Kakimasu ļauj tulkot projektu no pārlūka, neaiztiekot YAML failus, kuros pēc noklusējuma glabājas tulkojumi, līdz ar to, projektu var iztulkot bez īpašām priekšzināšanām, turklāt ātri, kas ietaupa tik dārgo laiku un līdzekļus. Paplašinājumu var lietot kā izstrādātāji, tā paši klienti. Paplašinājums ir izstrādāts Ruby programmēšanas valodā un tas ir saderīgs ar jebkuru Ruby on Rails 5 projektu. Paplašinājuma izstrādē tika izmantotas arī HTML, CSS, Javascript tehnoloģijas.
Ubiquitin ligase Rsp5p is involved in the gene expression changes during nutrient limitation inSaccharomyces cerevisiae
2009
Rsp5p is an essential ubiquitin ligase involved in many different cellular events, including amino acid transporters degradation, transcription initiation and mRNA export. It plays important role in both stress resistance and adaptation to the change of nutrients. We have found that ubiquitination machinery is necessary for the correct induction of the stress response SPI1 gene at the entry of the stationary phase. SPI1 is a gene whose expression is regulated by the nutritional status of the cell and whose deletion causes hypersensitivity to various stresses, such as heat shock, alkaline stress and oxidative stress. Its regulation is mastered by Rsp5p, as mutations in this gene lead to a lo…
Phylogenetic origin and transcriptional regulation at the post-diauxic phase of SPI1, in Saccharomyces cerevisiae
2012
15 pages, 4 figures, supplementary material
Social capital, public expenditure and the quality of provision. The Sicilian experience
2013
L'articolo si inserisce all’interno del dibattito sul divario nella qualità dei servizi fra Nord e Sud d’Italia che recentemente è tornato a concentrarsi sul tema del capitale sociale, con lo scopo di ricostruire i processi attraverso i quali il capitale sociale influenza i rendimenti istituzionali, di qualificare la natura del nesso esistente, la sua variabilità nel tempo e fra diversi settori di intervento. A questo scopo l'articolo sviluppa una analisi fra i settori della sanità e della formazione professionale negli ultimi dieci anni in Sicilia. Questo articolo si inserisce all'interno del dibattito sul divario nella qualità dei servizi fra Nord e Sud d'Italia che recentemente è tornato…