Search results for "IBA"
showing 10 items of 1355 documents
Hereditary angioedema in children and adolescents - A consensus update on therapeutic strategies for German-speaking countries.
2020
Background/methods At a consensus meeting in August 2018, pediatricians and dermatologists from German-speaking countries discussed the therapeutic strategy for the treatment of pediatric patients with type I and II hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH) for Germany, Austria, and Switzerland, taking into account the current marketing approval status. HAE-C1-INH is a rare disease that usually presents during childhood or adolescence with intermittent episodes of potentially life-threatening angioedema. Diagnosis as early as possible and an optimal management of the disease are important to avoid ineffective therapies and to properly treat swelling attacks. This art…
A Phase II Trial of Mitoxantrone plus Cyclophosphamide and 5-Fluorouracil in Modulation with Levo-Folinate for Advanced Breast Cancer Patients
1995
Advanced breast cancer remains a major clinical problem. Current chemotherapy regimens are able to induce a clinical response in many patients but do not appear to influence significantly patients' survival. The use of new drugs such as mitoxantrone with a predicted lower toxicity and biochemical modulation of 5-fluorouracil with levo-folinate are extensively studied research areas that could combine good therapeutic efficacy with the maintenance of an acceptable quality of life. 34 patients with advanced breast carcinoma were included in the study. Only 4 women had received prior chemotherapy for advanced disease. Treatment plan was: 5-fluorouracil 400 mg/m2 + l-leucovorin 100 mg/m2 days 1…
Effectiveness and safety of once-daily aminoglycosides: A meta-analysis
1996
The effectiveness and safety of once-daily versus several-times-daily aminoglycosides were studied in a meta-analysis. MEDLINE for 1988 to 1995 was searched, and additional studies were identified from review articles and references in retrieved articles. Studies selected for meta-analysis were randomized controlled clinical trials in nonneutropenic adult patients comparing the clinical effectiveness or nephrotoxicity or ototoxicity of once-daily with several-times-daily aminoglycosides. Differences between groups were expressed as odds ratios. The results were combined by the procedure of Mantel and Haenszel, and 95% confidence intervals and exact confidence intervals were computed. An odd…
Is Propionibacterium acnes related to disc degeneration in adults? A systematic review.
2016
Background The aim of this paper was to systematically review the evidence linking Propionibacterium acnes (P. acnes) with the development of symptomatic degenerative disc disease. Evidence acquisition Data were obtained from MEDLINE from their inception to October 2015. Two authors independently conducted the searches, extracted data and completed methodological quality assessments. Articles were included if they investigated the presence of P. acnes in symptomatic degenerative disc disease through intra-operative cultural examination. The methodological quality of the studies was evaluated using the Newcastle-Ottawa Scale. Evidence synthesis Overall 641 articles were retrieved with 9 cros…
Presencia de Vulpes praeglacialis (Kormos, 1932) en el yacimiento pleistoceno de la Sierra de Quibas (Abanilla, Murcia)
2006
We describe the first remains of Canidae from the Lower Pleistocene karstic locality of Quibas (Abanillas, Murcia) that increasing the representation of carnivores in this site. These fossils are identified as Vulpes praeglacialis, the typical Lower Pleistocene fox. This assignment is based on their small size and the poorly developed posterior cuspid of the p/3.
« Au nom du père ou les “autobiographies” de ceux qui ne dessinent pas (Altarriba, Gallardo, Spiegelman, Tardi) »
2015
International audience; Antonio Altarriba, Miguel Angel Gallardo, Art Spiegelman ou encore Jacques Tardi sont autant d'auteurs qui ont dessiné l'autobiographie de leur père. Ces égodocuments, qui sont des oeuvres en collaboration, peuvent-ils encore être qualifiés d'autobiographies ? Faut-il parler d'allobiographies ? d'altrobiographies ? Par ailleurs, ces autobiographies père-fils ajoutent une nouvelle strate contractuelle à ce genre qui n'en manquait déjà pas : celle du modèle maussien du don et du contre-don.
AUTOBIO-GRAPHISMES
2015
Autobio-graphismes, premier ouvrage en langue française dédié intégralement à l'analyse de l'autobiographie dans la bande dessinée, brosse une cartographie de cette pratique devenue caractéristique de la bande dessinée actuelle aux Etats-Unis et en Europe.
Cribado de alteraciones visuales (parte 2)
2015
En el presente trabajo se revisan y actualizan las recomendaciones de PrevInfad sobre el cribado de alteraciones visuales en la infancia. Se analizan los beneficios en salud de la deteccion precoz, la validez y seguridad de las pruebas de cribado, la efectividad del tratamiento y los posibles riesgos de la deteccion precoz y el tratamiento de los problemas detectados. PrevInfad recomienda incluir la inspeccion ocular y la prueba del reflejo rojo en las visitas de salud de los primeros seis meses de vida, asi como la deteccion de alteraciones visuales (ambliopia, estrabismo y errores de refraccion) a la edad de 3-5 anos. La evidencia para evaluar el balance entre los beneficios y los riesgos…
Cribado de alteraciones visuales (parte 1)
2014
En el presente trabajo se revisan y actualizan las recomendaciones de PrevInfad sobre el cribado de alteraciones visuales en la infancia. Se analizan los beneficios en salud de la deteccion precoz, la validez y seguridad de las pruebas de cribado, la efectividad del tratamiento y los posibles riesgos de la deteccion precoz y el tratamiento de los problemas detectados. PrevInfad recomienda incluir la inspeccion ocular y la prueba del reflejo rojo en las visitas de salud de los primeros seis meses de vida, asi como la deteccion de alteraciones visuales (ambliopia, estrabismo y errores de refraccion) a la edad de 3-5 anos. La evidencia para evaluar el balance entre los beneficios y los riesgos…
Faldaprevir (BI 201335), BI 207127 and ribavirin oral therapy for treatment-naive HCV genotype 1: SOUND-C1 final results
2013
Background Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection. This article describes the final results of the Phase Ib SOUND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1. Methods Patients were randomized to receive deleobuvir 400 mg ( n=15) or 600 mg ( n=17) three times daily plus faldaprevir 120 mg once daily and weight-based ribavirin for 4 weeks. Interferon-free therapy was followed by response-guided faldaprevir plus pegylated interferon-α2a/ribavirin to week 24 or 48. Results…