Search results for "ICAM"

Incorporation of specific wall proteins during yeast and mycelial protoplast regeneration in Candida albicans

1994

The kinectics of incorporation of two precursor mannoproteins into the regenerating cell wall of Candida albicans protoplasts have been followed at 28°C and 37°C using two monoclonal antibodies specific for protein epitopes (MAb 1B12 and 4C12) as probes. Both molecules were secreted from the beginning of the regeneration process, and their incorporation was retarded significantly. Analysis of the secreted materials by Western immunoblotting with MAb 1B12 allowed the identification of two closely migrating bands at apparent Mr higher than 170 kDa and significant amounts of a highly polydisperse material of even greater molecular mass. Some of these mannoproteinaceous species carried both N- …

Wall formation by Candida albicans yeast cells: synthesis, secretion and incorporation of two types of mannoproteins.

1993

SUMMARY: The mannoprotein components solubilized from the walls of Candida albicans blastoconidia following degradation of the glucan network with β-glucanase (Zymolyase) have higher molecular masses than their probable precursors present in the supernatant of regenerating protoplasts. It therefore appears that the mannoproteins are released from the walls as part of supramolecular complexes. Immunological analysis using both polyclonal and monoclonal antibodies has demonstrated the probable relationship between molecules found in a mixed membrane preparation, those secreted by regenerating protoplasts, and those present in yeast cell walls. Some mannoproteins secreted by protoplasts incuba…

Auditorijas uzticēšanās portālā "Skaties.lv" publicētajam saturam un to ietekmējošie faktori

2020

Bakalaura darba „Auditorijas uzticēšanās portālā “Skaties.lv” publicētajam saturam un to ietekmējošie faktori” mērķis ir noskaidrot un izpētīt, vai interneta lietotāji, īpaši “Skaties.lv” auditorija uzticas portāla publicētajam ziņu saturam un, kādi noteicošie faktori to ietekmē. Darba pētījuma objekts ir izklaides un ziņu portāla “Skaties.lv” auditorija un tās uzticamība medijam un tā publicētam saturam, kā arī, portāla redaktori, kuri veido saturu un publicē to internetā. Darba pētnieciskā problēma: Uzticēšanās medija saturam ir būtiska, jo tā nosaka lojalitāti medijam, medija reputāciju, tā apmeklētāju skaitu un medija ietekmi Latvijas mediju tirgū, kā arī, stiprina valsts informācijas t…

Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

2022

γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity. This research was funded by the National Na…

Water soluble organometallic small molecules as promising antibacterial agents: synthesis, physical-chemical properties and biological evaluation to …

2022

This work was supported by the Spanish Ministerio de Economia y Competitividad (PID2019-106832RB-100, and SAF2017-82261-P grant cofounded by the European Regional Development Fund) and the Generalitat de Catalunya (2017SGR1720). J. A. M. Xavier acknowledges DOC-FAM program under the Marie Sklodowska-Curie grant agreement N degrees 754397. A. B. Buades, M. Nuez and J. A. M. Xavier are enrolled in the PhD program of the UAB.

A Comparative Overview of the Canadian Senate and the British House of Lords

2018

The purpose of this overview is to highlight the role which is played by the Canadian Senate and the British House of Lords in their constitutional legal systems, and to attempt to underline what similarities or differences can be identified in relation to their composition and functions. This paper will analyse whether they have an actual representative capacity and if they are able to perform the typical functions which are normally allocated to the upper chambers, functioning as a “sober second thought” and a house of check on the majority expressed in the lower chamber, usually connected to the Cabinet. The contribution of these chambers to parliamentary systems of government will also …

In-vitro test system for the evaluation of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibitors based on a single HPLC run with UV detect…

2001

Objective and Design: The aim of this study was to develop a new, whole-cell test system which is easy to handle and requires a standard equipment for the parallel screening of COX-1 and COX-2 inhibitors.¶Materials: Bovine aortic endothelial cells (BAECs).¶Treatment and methods: Unstimulated bovine aortic coronary endothelial cells (BAECs) were used as a source of COX-1 and BAECs pretreated with ASA (100 μM) and activated with phorbol myristate acetate (PMA) were used as a source of COX-2. The time- and concentration-dependent induction of COX-2 expression in the BAECs was evaluated by a kinetic profile (HPLC analysis) and detected by Western-Blot analysis using polyclonal antibodies agains…

Composantes culturelles et Premières productions céramiques du Bronze ancien dans le sud-est de la France

2012

The collective research project "Cultural components of the first pottery productions of the Early Bronze Age in Southeast France" derives from renewal of documentation on the Early Bronze Age in the southeast Rhodanian region and new approaches to the Bell Beaker period, particularly in the southern part of Southeast France. In 1998, the Riva del Garda conference constituted a high point in Bell Beaker research at a European scale, of which the consequences and questions motivated the collective project for an overview of the transition from the end of the Neolithic to the Early Bronze Age in a large southeastern quarter of France. In these regions, issues relating to the future of Bell Be…

C-reactive protein and ICAM-1 are stronger predictors of oxidant stress than blood pressure in established hypertension

2006

Pharmaceutical patents and the right to access to medicines in Central America

2020

El vínculo entre la propiedad intelectual y el derecho a la salud se ha convertido en un tema de debate central desde la conferencia ministerial de la Organización Mundial del Comercio (OMC) en 2001. En efecto, a pesar del amplio reconocimiento del derecho a la salud en la escena internacional, la cuestión de la protección efectiva y la aplicación del derecho en cuestión es tema de un debate constante. El objetivo de las patentes farmacéuticas, es proporcionar al inventor un conjunto de derechos exclusivos durante un período de tiempo determinado a cambio de la divulgación pública del medicamento recién protegido. El régimen de monopolio establecido conduce a un aumento significativo de los…