Search results for "ICT."

Immuno-SLM—a combined sample handling and analytical technique

2004

Immuno-supported liquid membrane (immuno-SLM) extraction is a new technique that makes use of antibody (Ab)-antigen interactions as the "extraction force" to drive the mass transfer in a selective way. In immuno-SLM, anti-analyte (Ag) Abs are introduced into the acceptor phase of the SLM unit to trap the Ag that passes from the flowing donor through the SLM into the stagnant acceptor. The amount of immuno-extracted analyte (AbAg) is quantified by connecting the immuno-SLM unit on-line with a non-competitive heterogeneous fluorescence flow immunoassay (FFIA) that makes use of a fluorescein-labeled analyte tracer that titrates the residual excess of Ab present in the acceptor. A restricted ac…

Receptor Activator of NF-kB (RANK) Expression in Primary Tumors Associates with Bone Metastasis Occurrence in Breast Cancer Patients

2011

Background\ud Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG.\ud \ud Materials and Methods\ud We examined mRNA expression levels of RANKL/RANK/OPG in a publicly available microarray dataset of 295 primary breast cancer patients. We next analyzed RANK expression by immunohistochemistry in an independent series of 93 primary breast cancer specimens and investigated a possible association with clinicopathological parameters, bone recurrence and surviv…

Have Day 3 Embryo Morphology a Predictive Value in Blastocyst Formation?

2000

“Facts Are Grasped by Us in Pictures (PT, 2.1). Remarks on Pictures and Facts in Wittgenstein’s Tractatus

2023

This paper proposes a (re)reading of the famous section in the Tractatus Logico-philosophicus, 2.1: “We picture facts to ourselves” and its relation to the similar section in the Prototractatus, 2.1: “Facts are grasped by us in images”. We reject the dominant solution that interprets the relation between facts and images as an isomorphic relation and propose that instead it is an internal relation: there are no facts that are not perceived through images. In other words: For us, linguistic animals, there is no world independent of language.

Expression of proteolitic enzymes in induced angiogenesis

2008

Angiogenesis (growth of new blood vessels) plays a key role in tissue repair, such as in cancer progression (Folkman 1995. New Engl. J. Med. 333, 1757-63). At the beginning of the process is observed the matrix degradation and endothelial cells (ECs) migration inside to the connective tissue in proximity of vessel walls. During angiogenesis several modifications occurs at plasma membrane level; a redistribution of cell-cell and cell-matrix adhesion molecules (Bazzoni et al 1999), such as an increased expression of several proteolytic enzymes, including MMPs and serine proteases, as plasminogen activators and SIMPs, were observed (Ghersi et al. 2006. Cancer Res. 66, 4652-61; Ghersi 2008 Fron…

Role of MT1-MMP in cell-cell contact formation of endothelial cells

2008

A new hybrid method to improve the ultra-short-term prediction of LOD

2019

Accurate, short-term predictions of Earth orientation parameters (EOP) are needed for many real-time applications including precise tracking and navigation of interplanetary spacecraft, climate forecasting, and disaster prevention. Out of the EOP, the LOD (length of day), which represents the changes in the Earth’s rotation rate, is the most challenging to predict since it is largely affected by the torques associated with changes in atmospheric circulation. In this study, the combination of Copula-based analysis and singular spectrum analysis (SSA) method is introduced to improve the accuracy of the forecasted LOD. The procedure operates as follows: First, we derive the dependence structur…

Between Life and Existence. Heidegger’s Aristotelianism and the Question of Animality

2021

This paper starts by investigating the Aristotelian roots of Heidegger’s stance toward animal life from 1924 lecture course “Basic concepts of Aristotelian philosophy” to 1929/30 lecture course “The fundamental concepts of Metaphysics”. In following Aristotle, Heidegger displays the ontological transition from life to existence as grounded to the peculiar linguistic ability of human beings. In doing that, both Heidegger and Aristotle seem to establish a connection between an existential faculty (logos) and the apparently dominant position occupied by our species. On the other side, though, to be endowed with logos means for human beings to be able to de-centre themselves in recognizing the …

Macrophage Migration Inhibitory Factor Induces Inflammation and Predicts Spinal Progression in Ankylosing Spondylitis

2017

Objective: To investigate the role of macrophage migration inhibitory factor (MIF) in the pathogenesis of ankylosing spondylitis (AS). Methods: Patients who met the modified New York criteria for AS were recruited for the study. Healthy volunteers, rheumatoid arthritis patients, and osteoarthritis patients were included as controls. Based on the annual rate of increase in modified Stoke AS Spine Score (mSASSS), AS patients were classified as progressors or nonprogressors. MIF levels in serum and synovial fluid were quantitated by enzyme-linked immunosorbent assay. Predictors of AS progression were evaluated using logistic regression analysis. Immunohistochemical analysis of ileal tissue was…

Fractional-order constitutive equations in mechanics and thermodynamics

2019

This chapter is devoted to the application of fractional calculus in mechanics of materials and thermodynamics. The use of fractional calculus in mechanics is related to the definition of fractional-order constitutive equations leading to the class of fractional hereditariness. In this regard, a brief description of the classical rheological models of material hereditariness and a comparison with the fractional elements are reported. It is shown that a rheological hierarchy corresponding to the fractional order stress-strain relation may be defined. Such a model provides a multi-scale mechanical picture of the power-law hereditariness and it leads toward an unique definition of material fre…