Search results for "ICT."

Population-based study of breast cancer in older women: prognostic factors of relative survival and predictors of treatment

2012

Abstract Background A large proportion of women with breast cancer (BC) are elderly. However, there is a lack of information regarding BC prognostic factors and care in this population. The aims of this study were to assess the prognostic factors of relative survival (RS) among women with BC aged ≥ 75 years old and to identify the predictive factors of treatments administered to this population. Methods A population-based study was performed using data from the Cote d’Or breast and gynaecological cancer registry. Women aged 75 years and older with primary invasive BC and resident in Cote d’Or at the time of diagnosis made between January 1998 and December 2008 were retrospectively selected.…

Droloxifene-Induced Spikes of Tumor Markers Predict Benefit of Therapy

1991

In the clinical monitoring of cancer, tumor marker proteins may reflect the status of the disease. In cases with radio- and chemotherapy, spikes of tumor markers were found shortly after starting the therapy. These spikes were interpreted as a sign of tumor lysis. Recently during therapy of breast cancer with the new antiestrogen droloxifene, spikes of CA 125 and CA 15-3 were also found in about one-third of patients responding to therapy. The peaks of these initial increases were recorded between 14 and 60 days after the onset of treatment, with maximum concentrations up to 1,890% of the initial value. Marker concentrations decreased thereafter, to new baselines at or below the initial val…

Body mass index and baseline platelet count as predictive factors in Merkel cell carcinoma patients treated with avelumab

2023

BackgroundMerkel cell carcinoma (MCC) is a rare and aggressive skin cancer, associated with a worse prognosis. The Immune Checkpoint Inhibitors (ICIs) avelumab and pembrolizumab have been recently approved as first-line treatment in metastatic MCC (mMCC). The clinical observation of improved outcomes in obese patients following treatment with ICIs, known as the “obesity paradox”, has been studied across many types of tumors. Probably due to the rarity of this tumor, data on mMMC patients are lacking.Patients and methodsThis is an observational, hospital-based, study to investigate the role of Body Mass Index (BMI) as predictive biomarker of ICI response in mMCC patients treated with aveluma…

Risultati di un test RFLP su ceppi vaccinali di Canine Distemper Virus in Italia

2013

Canine Distemper (CD) is a highly contagious and multisystemic viral disease of domestic and wild carnivores. A published Restriction Fragment Length Polymorphism (RFLP) test, based on the presence of a PsiI cleavage site on hemagglutinin (H) gene, allows a rapid differentiation of all currently used vaccine strains by virulent field strains. The present study describes the results of this test carried out on different CD vaccines available in Italy in 2010. RFLP has also revealed that the CD strain present in the Vanguard (Pfizer Animal Health) vaccine reacts as a wild-type strain. Moreover, genetic analysis of H gene sequence has showed that Vanguard vaccine strain does not cluster in the…

Acetaldehyde as a drug of abuse: insight into AM281 administration on operant-conflict paradigm in rats

2013

Increasing evidence focuses on acetaldehyde (ACD) as the mediator of the rewarding and motivational properties of ethanol. Indeed, ACD stimulates dopamine release in the nucleus accumbens and it is self-administered under different conditions. Besides the dopaminergic transmission, the endocannabinoid system has been reported to play an important role in ethanol central effects, modulating primary alcohol rewarding effect, drug-seeking and relapse behaviour. Drug motivational properties are highlighted in operant paradigms which include response-contingent punishment, a behavioural equivalent of compulsive drug use despite adverse consequences. The aim of this study was thus to characterize…

Más allá de Vainica Doble: Carmen Santonja, pintora

2009

Este artículo analiza la trayectoria pictórica de Carmen Santonja (Madrid, 1934- 2000). Aunque ha sido más conocida como cantante, ya que formó parte del célebre grupo Vainica Doble, C. Santonja también se dedicó con intensidad a otras disciplinas artísticas cine, televisión , destacando especialmente su vocación pictórica. Sus obras, como su música, reflejarán el gusto por la naturaleza dentro de una estética pop, mostrando gran interés por la experimentación, que le llevará a la creación de nuevas técnicas, como el decollage. (A)

Dynamics and Predictability of a Heavy Dry-Season Precipitation Event over West Africa—Sensitivity Experiments with a Global Model

2009

Abstract In January 2002 the Cape Verde region in tropical West Africa was hit by an exceptionally heavy precipitation event. Rain rates of up to 116 mm (48 h)−1 caused harmful impacts on the local population. The rainfall was triggered by a series of two upper-level disturbances penetrating from the extratropics to the West African coast. This study investigates the dynamics and predictability of this event on the basis of simulations with the global model Global Model Europe (GME) of the German Weather Service [i.e., Deutscher Wetterdienst (DWD)] initialized by the European Centre for Medium-Range Weather Forecasts (ECMWF) analysis data. Free forecasts satisfactorily reproduce the upper-l…

Building a model of corporate social responsibility in the old industrial region(in the case of Upper Silesia): a sociological perspective

2009

PurposeCorporate social responsibility (CSR) is one of the most crucial phenomena of global capitalism at the beginning of the twenty‐first century. For this reason it is emphasized by many companies (especially transnational corporations and multinational companies) and in the European Union and its policy. The main purpose of this paper is to analyze how CSR exists in a transitional country and region – the Upper Silesian Industrial District and the Rybnik Coalmine Area in Southern Poland.Design/methodology/approachA qualitative and quantitative methodology was used to summarize the sociological research among entrepreneurs and businesses located throughout the region.FindingsThis researc…

RIBOSOMAL SUBUNIT EXCHANGE IN DICTYOSTELIUM PURPUREUM

1970

State of the Art on Sustainability Assessment of Positive Energy Districts: Methodologies, Indicators and Future Perspectives

2021

The concept of Positive Energy District is one of the main areas of research and extensive applications of the principles of the clean energy transition within the building sector. In the past years, the most widely accepted definitions have focused specifically on carbon neutrality, while several other aspects regarding all sustainability approaches (including environmental, social and economic perspective) were included qualitatively or to a lesser degree. This paper proposes a discussion on the state of the art of the sustainability assessment of Positive Energy Districts, by investigating environmental, social and economic sustainability applications. The three sustainability dimensions…