Search results for "IDP"
showing 6 items of 36 documents
Calidad de vida oral en adolescentes y su relación con el estado de salud oral
2022
Introducción.La calidad de vida oral es un constructo multidimensional que incluye la repercusión de la salud oral sobre aspectos físicos, psicológicos, funcionales y sociales.Desde su validación en España en 2010 el cuestionario Child-Oral Impacts on Daily Performances no se había aplicado en adolescentes, por lo que se propone su uso para analizar la calidad de vida oral a los 13-15 años de edad y relacionarla con el estado de salud oral y otros factores.Material y métodos.Se diseñó un estudio transversal, en una muestra de 337 escolares de la Comunidad Valenciana.Se obtuvo aprobación del Comité de Ética y el consentimiento informado de los participantes y sus padres.Se recogieron datos s…
Sperm morphological abnormalities appearing in the male rabbit reproductive tract
1996
The role of the excurrent duct system in producing and/or eliminating morphologically abnormal spermatozoa may modify the semen parameters and interfere with sperm fertilizing capacity. To study this process, changes in the morphology of spermatozoa during their transit through the reproductive tract in sexually mature rabbits were investigated. The incidence of head, midpiece and tail abnormalities as well as of multiple defects in a single spermatozoon, and the position of the cytoplasmic droplet along the sperm midpiece were evaluated in samples from the testis, 6 regions of the epididymis and the vas deferens. Spermatozoa were characterized by rapid migration of the cytoplasmic droplet …
Missing a lot of this world : formal education and political competition in Iraq through a Yezidi lens
2017
This thesis examines Yezidi perceptions of access to formal education for Yezidi children and youth from the Sinjar region of Iraq, a primary homeland of the Yezidi people and an officially disputed territory between the Kurdistan Regional Government (KRG) and the federal government of Iraq in Baghdad, between the periods of 2003–2014 and 2014 onwards. These two time frames are selected and differentiated to reflect two major events in the recent history of Sinjar – the downfall of Saddam Hussein’s regime in 2003 and subsequent de facto control of Sinjar by the KRG, and the seizing of the area by the Islamic State (IS) group and subsequent displacement of the majority of the Yezidi communit…
The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A
2021
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has recently been connected to several human cancer types. Accordingly, the knowledge about ARPP-19—PP2A inhibition mechanism is crucial for the understanding the disease development and the therapeutic targeting of ARPP-19—PP2A. Here, we show the first structural characterization of ARPP-19, and its splice variant ARPP-16 using NMR spectroscopy, and SAXS. The results reveal that both ARPP proteins are intrinsically disordered but contain transient…
Expression pattern of matrix metalloproteinases-2 and -9 and their tissue inhibitors in patients with chronic inflammatory demyelinating polyneuropat…
2021
Background: Matrix metalloproteinases (MMPs) are a heterogeneous family of endopeptidases that play a role in many physiological functions, including the immune response. An imbalance between the activity of MMPs and their physiological tissue inhibitors (TIMPs) has been proposed in the pathophysiology of different autoimmune disorders. We aimed to assess the plasmatic levels of MMP-2, MMP-9, and their inhibitors TIMP-1 and -2 in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Subjects and methods: Twenty patients with CIDP and 20 age- and sex-matched healthy controls were enrolled. Plasma concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were determined by the enzy…
Relevance of diagnostic investigations in chronic inflammatory demyelinating poliradiculoneuropathy: Data from the Italian CIDP database
2020
The objective of our work was to report the clinical features and the relevance of diagnostic investigations in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We retrospectively reviewed data from patients with a clinical diagnosis of CIDP included in a national database. Among the 500 included patients with a clinical diagnosis of CIDP, 437 patients (87%) fulfilled the European Federation of Neurological Societies and Peripheral Nerve Society criteria for CIDP (definite in 407, probable in 26, possible in four). In 352 patients (86%) motor nerve conduction abnormalities consistent with demyelination were sufficient for the diagnosis of definite CIDP. In 55 …