Search results for "IDPS"
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The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A
2021
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has recently been connected to several human cancer types. Accordingly, the knowledge about ARPP-19—PP2A inhibition mechanism is crucial for the understanding the disease development and the therapeutic targeting of ARPP-19—PP2A. Here, we show the first structural characterization of ARPP-19, and its splice variant ARPP-16 using NMR spectroscopy, and SAXS. The results reveal that both ARPP proteins are intrinsically disordered but contain transient…
Missing a lot of this world : formal education and political competition in Iraq through a Yezidi lens
2017
This thesis examines Yezidi perceptions of access to formal education for Yezidi children and youth from the Sinjar region of Iraq, a primary homeland of the Yezidi people and an officially disputed territory between the Kurdistan Regional Government (KRG) and the federal government of Iraq in Baghdad, between the periods of 2003–2014 and 2014 onwards. These two time frames are selected and differentiated to reflect two major events in the recent history of Sinjar – the downfall of Saddam Hussein’s regime in 2003 and subsequent de facto control of Sinjar by the KRG, and the seizing of the area by the Islamic State (IS) group and subsequent displacement of the majority of the Yezidi communit…