Search results for "IFS."
showing 10 items of 362 documents
Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome: A randomized, double-blind study
2011
International audience; AIM: To assess the effects and safety of Lactobacillus casei rhamnosus LCR35 complete freeze-dried culture (LCR35) in patients suffering from irritable bowel syndrome (IBS). METHODS: A randomized, double-blind pilot study was performed in 50 patients complaining of IBS symptoms complying with Rome III criteria. Patients were allocated to receive either LCR35 (n = 25) at a minimum daily dose of 6 × 10(8) colony forming units or placebo (n = 25) for 4 wk. At inclusion, after treatment and 2 wk later, patients completed the IBS severity scale. Change from baseline in the IBS severity score at the end of treatment was the primary efficacy criterion. Changes were compared…
Different conformations of nascent polypeptides during translocation across the ER membrane
2000
Abstract Background In eukaryotic cells, proteins are translocated across the ER membrane through a continuous ribosome-translocon channel. It is unclear to what extent proteins can fold already within the ribosome-translocon channel, and previous studies suggest that only a limited degree of folding (such as the formation of isolated α-helices) may be possible within the ribosome. Results We have previously shown that the conformation of nascent polypeptide chains in transit through the ribosome-translocon complex can be probed by measuring the number of residues required to span the distance between the ribosomal P-site and the lumenally disposed active site of the oligosaccharyl transfer…
Bibliographie nodiériste en ligne : œuvres et paratextes critiques
2011
Bibliographie en ligne autour des œuvres de Charles Nodier progressivement mise en place sur le site des Cahiers d'études nodiéristes. Projet d'envergure évolutif et chronologiquement rétrospectif : sa première étape couvrant la période 2000 à nos jours est opérationnelle.URL : http://www.cahiers-nodieristes.fr/bibliographie.html
Le malade cancéreux en soins palliatifs
2008
The Functional Role of the Second NPXY Motif of the LRP1 β-Chain in Tissue-type Plasminogen Activator-mediated Activation of N-Methyl-D-aspartate Rec…
2008
The low density lipoprotein receptor-related protein 1 (LRP1) emerges to play fundamental roles in cellular signaling pathways in the brain. One of its prominent ligands is the serine proteinase tissue-type plasminogen activator (tPA), which has been shown to act as a key activator of neuronal mitogen-activated protein kinase pathways via the N-methyl-D-aspartate (NMDA) receptor. However, here we set out to examine whether LRP1 and the NMDA receptor might eventually act in a combined fashion to mediate tPA downstream signaling. By blocking tPA from binding to LRP1 using the receptor-associated protein, we were able to completely inhibit NMDA receptor activation. Additionally, inhibition of …
Le renouvellement du contrôle juridictionnel de l’administration au moyen du recours pour excès de pouvoir
2017
The role of the administrative judge (the excess of power) has evolved due to the implementation of the various texts adopted recently as well as the developments in the case-law in recent years. In many areas, its role now goes beyond the mere confrontation of an administrative act with the rule of law. At the heart of the annulment decision is a statement and an assessment of the facts, apart from the interpretation of the law, which were usually separated by the principle of separation between the administration and its judge.Some jurisprudence which has become very classical, as well as others more recent, can be considered as characteristic manifestations of this new tendency of the ju…
Interaction and use of technologies in teaching and learning processes
2020
El nuevo escenario de la sociedad del conocimiento y los desafíos de aprendizaje que debe enfrentar la educación en este milenio han sido determinados por la transformación del mundo en las esferas económicas, políticas y culturales. En este artículo analizamos los procesos de interacción que se producen en los contextos educativos cuando las tecnologías son una oportunidad para lograr cambios profundos que contribuyan a mejorar los procesos de enseñanza aprendizaje desde nuevos planteamientos pedagógicos y curriculares. Todo ello conlleva una reorganización de los centros educativos, la formación y actualización del profesorado y la colaboración de las familias. Los docentes tienen ante sí…
Avoided motifs: short amino acid strings missing from protein datasets.
2020
Abstract According to the amino acid composition of natural proteins, it could be expected that all possible sequences of three or four amino acids will occur at least once in large protein datasets purely by chance. However, in some species or cellular context, specific short amino acid motifs are missing due to unknown reasons. We describe these as Avoided Motifs, short amino acid combinations missing from biological sequences. Here we identify 209 human and 154 bacterial Avoided Motifs of length four amino acids, and discuss their possible functionality according to their presence in other species. Furthermore, we determine two Avoided Motifs of length three amino acids in human proteins…
Résistance à la corrosion d'interconnecteurs métalliques de piles à combustibles de type SOFC : Influence de la vapeur d'eau
2008
Les interconnecteurs représentent une pièce maîtresse des piles à combustibles à oxyde solide (Solid Oxide Fuel Cells : SOFCs) car ils sont chargés de collecter et de délivrer le courant produit par la pile. Les matériaux d'interconnecteurs sont à la fois en contact avec l'anode et la cathode et doivent donc être parfaitement stables dans l'air (côté cathodique) et dans l'hydrogène enrichie en vapeur d'eau (côté anodique). Les matériaux métalliques les plus prometteurs sont les chromino-formeurs. Ces alliages sont choisis car, à haute température, ils forment une couche de chromine, Cr2O3, protectrice vis-à-vis des conditions corrosives de fonctionnement de la pile. Cependant, cette couche …
The Protein Structure Context of PolyQ Regions.
2016
Proteins containing glutamine repeats (polyQ) are known to be structurally unstable. Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to neurodegenerative disease, a symptom of which are protein aggregates. This has led to extensive research of the structure of polyQ stretches. However, the accumulation of contradictory results suggests that protein context might be of importance. Here we aimed to evaluate the structural context of polyQ regions in proteins by analysing the secondary structure of polyQ proteins and their homologs. The results revealed that the secondary structure in polyQ vicinity is predominantly random coil or helix. Importantly, the region…