Search results for "IGF-1."
showing 9 items of 19 documents
MAGNESIUM AND ANABOLIC HORMONES IN OLDER MEN
2011
Optimal nutritional and hormonal statuses are determinants of successful age-ing. The age associated decline in anabolic hormones such as testosterone and insulin-like growth factor 1 (IGF-1) is a strong predictor of metabolic syn-drome, diabetes and mortality in older men. Studies have shown that magne-sium intake affects the secretion of total IGF-1 and increase testosterone bioactivity. This observation suggests that magnesium can be a modulator of the anabolic ⁄ catabolic equilibrium disrupted in the elderly people. However, the relationship between magnesium and anabolic hormones in men has not been investigated. We evaluated 399 ‡65-year-old men of CHIANTI in a study population repres…
The effect of exercise intensity and exercise environment on brain-derived neurotrophic factor (BDNF) and physiologic parameters in young male skiers
2017
Ruostekoski, Anni. 2017. Intensiivisen intervalliharjoituksen ja harjoitusympäristön vaikutus aivoperäiseen hermokasvutekijään ja fysiologisiin vasteisiin nuorilla mieshiihtäjillä. Liikuntabiologia, Jyväskylän yliopisto, Liikuntafysiologian Pro Gradu- tutkielma, 64s. Johdanto. Tutkimukset ovat osoittaneet, että liikunnalla ja aivojen hyvinvoinnilla on selkeä yhteys. Liikunnan aivoille suotuisten vaikutusten välittäjäaineena näyttää toimivan aivoperäinen hermokasvutekijä (BDNF). Liikunnan on osoitettu akuutisti nostavan veren BDNF- pitoisuutta ja BDNF- pitoisuuden nousu näyttää olevan riippuvainen liikunnan intensiteetistä, sekä taito- vaatimuksista. Myös kortisoli ja IGF-1 saattavat liittyä…
Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.
2010
Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50–57-year-old women. The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E2; 1 mg norethisterone acetate, NETA, n = 10) or placebo (CO, n = 9). Microarray technology and quantitative PCR (qPCR) were used to study the expression of insulin-like growth factor I (IGF-1) and its splice variants as well as IGF-1 receptor, Akt1, mTOR, FOXO1, FOXO3, atrog…
Hormonikorvaushoidon vaikutus lihaksen lihassolutyyppeihin ja insuliinin kaltaiseen kasvutekijä 1:een ikääntyvillä naisilla
2010
Ikääntymisen myötä luustolihaksen rakenteessa ja toiminnassa tapahtuu monia muutoksia, jotka vaikuttavat lihaksen massaan ja suorituskykyyn heikentävästi. Lihassolujen määrä ja koko vähenee sekä rasva- ja sidekudoksen määrä lihaksessa kasvaa. Näihin muutoksiin vaikuttavat mm. hormonaaliset tekijät, mutta taustalla olevia tarkkoja mekanismeja ei vielä tunneta. Naisilla lihasvoiman heikkenemisen on havaittu kiihtyvän vaihdevuosi-iässä ja hormonikorvaushoidon on havaittu hidastavan tätä ilmiötä. Kaikki tutkimukset eivät kuitenkaan ole antaneet yhdenmukaisia tuloksia. Estrogeeni on kuitenkin yksi todennäköinen vaikuttaja lihaksen toiminnan säätelyssä, ja lihassolujen onkin todettu ilmentävän se…
Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-233 expressions: A study on postmenopausal mon…
2014
MiRNAs are fine-tuning modifiers of skeletal muscle regulation, but knowledge of their hormonal control is lacking. We used a co-twin case–control study design, that is, monozygotic postmenopausal twin pairs discordant for estrogen-based hormone replacement therapy (HRT) to explore estrogen-dependent skeletal muscle regulation via miRNAs. MiRNA profiles were determined from vastus lateralis muscle of nine healthy 54–62- years-old monozygotic female twin pairs discordant for HRT (median 7 years). MCF-7 cells, human myoblast cultures and mouse muscle experiments were used to confirm estrogen’s causal role on the expression of specific miRNAs, their target mRNAs and proteins and finally the ac…
Serum sex-hormone binding globulin and cortisol concentrations are associated with overreaching during strenuous military training
2011
The purpose was (a) to study the effect of an 8-week Finnish military basic training period (BT) on physical fitness, body composition, mood state, and serum biochemical parameters among new conscripts; (b) to determine the incidence of overreaching (OR); and (c) to evaluate whether initial levels or training responses differ between OR and noOR subjects. Fifty-seven males (19.7 ± 0.3 years) were evaluated before and during BT. Overreaching subjects had to fulfill 3 of 5 criteria: decreased aerobic physical fitness (VO2max), increased rating of perceived exertion (RPE) in 45-minute submaximal test at 70% of VO2max or sick absence from these tests, increased somatic or emotional symptoms of …
Valor de la distribución de la grasa corporal, medida por impedanciometría bioeléctrica, y del factor de crecimiento similar a la insulina-1 en el di…
2015
A pesar de que hoy en día se considera al cáncer de próstata (CaP) como una de las principales enfermedades neoplásicas a las que se enfrenta la población masculina, los factores que determinan el riesgo de padecer CaP no se conocen claramente. Sólo la edad, la herencia y la etnicidad se consideran factores asociados a un mayor riesgo de padecer CaP. La influencia de los factores exógenos en la incidencia de este cáncer puede explicar las diferencias del CaP clínico entre EE.UU y Europa Occidental frente a países del sudeste Asiático. Se estipula que en los pacientes obesos la asociación con el CaP se puede producir mediante un aumento de estrógenos por aromatización periférica de andrógeno…
Association between genetic variations in the insulin/insulin-like growth factor (Igf-1) signaling pathway and longevity: a systematic review and met…
2013
Some studies have shown that polymorphisms in the insulin growth factor-1 (IGF-1) signaling pathway genes could influence human longevity. However, the results of different studies are often inconsistent. Our aim was to investigate by systematic review and meta-analysis the association of the common polymorphisms defining the genetic variability of the IGF-1 signaling pathway associated with human longevity. Eleven studies investigating the association between the polymorphisms in the IGF-1 signaling pathway genes (IGF-1, IGF-1 receptor (IGF-1R), Forkhead box O3A (FOXO3A) and Silent mating type Information Regulation 1 (SIRT1) and longevity were found and analyzed. The modelfree approach wa…
Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment.
2018
Acromegaly is a rare disease due to chronic GH excess and to the consequent increase in IGF-1 levels. Both GH and IGF-1 play a role in intermediate metabolism affecting glucose homeostasis. Indeed, chronic GH excess impairs insulin sensitivity, increases gluconeogenesis, reduces the glucose uptake in adipose tissue and muscle and alters pancreatic β cells function. As a consequence, glucose metabolism alterations are a very frequent complication in acromegaly patients, further contributing to the increased cardiovascular risk and mortality. Treatment modalities of acromegaly differently impact on glucose tolerance. Successful surgical treatment of acromegaly ameliorates glucose metabolism a…