Search results for "IH"

Evaluating the potential for evolutionary mismatch in Batesian mimics: A case study in the endangered smooth snake (Coronella austriaca)

2018

Many harmless organisms gain a survival advantage by mimicking venomous species. This is the case of the endangered smooth snake (Coronella austriaca), which mimics venomous vipers. Although this may protect the smooth snake against most of its natural predators, it may render them at greater risk of mortality from humans, who are more inclined to kill species, such as vipers, that they consider dangerous. This may cause an evolutionary mismatch, whereby humans may counteract the natural advantage of mimicry. We explore this possibility of evaluating the willingness of humans to kill smooth snakes versus the adder (Vipera berus), as well as their ability to discern them in the Åland Islands…

Neighbor-list-free molecular dynamics on sunway TaihuLight supercomputer

2020

Molecular dynamics (MD) simulations are playing an increasingly important role in many research areas. Pair-wise potentials are widely used in MD simulations of bio-molecules, polymers, and nano-scale materials. Due to a low compute-to-memory-access ratio, their calculation is often bounded by memory transfer speeds. Sunway TaihuLight is one of the fastest supercomputers featuring a custom SW26010 many-core processor. Since the SW26010 has some critical limitations regarding main memory bandwidth and scratchpad memory size, it is considered as a good platform to investigate the optimization of pair-wise potentials especially in terms of data reusage. MD algorithms often use a neighbor-list …

SWMapper: Scalable Read Mapper on SunWay TaihuLight

2020

With the rapid development of next-generation sequencing (NGS) technologies, high throughput sequencing platforms continuously produce large amounts of short read DNA data at low cost. Read mapping is a performance-critical task, being one of the first stages required for many different types of NGS analysis pipelines. We present SWMapper — a scalable and efficient read mapper for the Sunway TaihuLight supercomputer. A number of optimization techniques are proposed to achieve high performance on its heterogeneous architecture which are centered around a memory-efficient succinct hash index data structure including seed filtration, duplicate removal, dynamic scheduling, asynchronous data tra…

Care Workers’ Readiness for Robotization : Identifying Psychological and Socio-Demographic Determinants

2020

Successful implementation of robots in welfare services requires that the staff approves of them as a part of daily work tasks. In this study, we identified psychological and socio-demographic determinants associated with readiness for robotization among professional Finnish care-workers. National survey data were collected from professional care workers (n = 3800) between October and November 2016. Random samples were drawn from the member registers of two Finnish trade unions. The data were analyzed with regression models for respondents with and without firsthand experience with robots. The models explained 34–39% of the variance in the readiness for robotization. The readiness was posit…

Los primeros grados de la Universidad de Orihuela (1610-1643)

2017

Resilience to flash floods in wetland communities of northeastern Bangladesh

2018

Globally, a number of catastrophic hydrometeorological hazards occurred in 2017 among which the monsoon floods in South Asia was particularly disastrous, killing nearly 1200 people in India, Nepal and Bangladesh. The wetland region (Haor) of northeastern (NE) Bangladesh was severely affected by flash floods early in 2017, affecting nearly 1 million households and damaging US $450 million worth of rice crops. This study investigates how the NE Bangladesh experienced the 2017 flash floods, and to what degree the wetland communities are vulnerable and resilience to flash floods. Focus group discussion, key informant interviews, and household questionnaire surveys (n = 80) were applied in the s…

A systematic review of human behaviour in and around floodwater

2020

Abstract Flooding can have a major impact on people's safety and livelihood. Understanding people's flood-related behaviours may assist in the development of more effective strategies aimed at lessening the impact of floods including mortality and morbidity. This systematic review examined peer-reviewed literature published from January-1989 to April-2019 on human behaviour in and around floodwater to identify behaviour patterns as well as protective and risk factors. We extracted three main themes from a thematic analysis of included studies (N = 54): activities and risk-taking behaviours (n = 24); loss reduction, knowledge, and warnings (n = 37); and diet and hygiene (n = 4). This review …

EL PAPEL DE LA AUTOESTIMA EN LA PREVENCIÓN DEL VIH DE JÓVENES ESPAÑOLES

2017

Abstract.THE ROLE OF SELF-ESTEEM IN HIV PREVENTION AMONG SPANISH YOUNG PEOPLE SELF-ESTEEM INFLUENCES ON SEXUAL DEVELOPMENT AND RELATIONSHIPS OF YOUNG PEOPLE.Aims to examine the effects of the self-esteem on HIV prevention, 467 young people from the Valencian Community (Mage = 20.62; SD = 2.14) completed the Rosenberg Self-esteem Scale and the Aids Prevention Questionnaire by Ballester et al. (2007). Results showed statistically significant positive correlation between self-esteem and self-efficacy in condom use (p = .000), perceived competence (p = .041) or number of sexual partners (p = .001). On the other hand, statistically significant negative correlation were found between solidarity t…

Synthesis and Cytotoxicity of 1,4-Dihydropyridines and an Unexpected 1,3-Oxazin-6-one

2016

Eight heterocycles have been prepared in a one-pot reaction manner based on the Hantzsch dihydropyridine synthesis. The synthesis afforded seven dihydropyridines (DHP) and one unexpected 1,3-oxazin-6-one. Their structures were confirmed based on NMR spectroscopy and mass spectrometry. The obtained products have been evaluated for their cytotoxicity against eight cancer cell lines and one normal cell line. Two halogenated DHPs (7 and 8) displayed cytotoxicity toward all the nine tested cancer cell lines with IC50 values from 4.10 to 58.90 μm, while others showed selective activities. DHPs (7 and 8) bearing a Me group at C(2) and C(6) as well as a halogenated substituent at C(4′) were more an…

2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors

2016

International audience; 2,3-Dihydrobenzofurans are proposed as privileged structures and used as chemical platform to design small compound libraries. By combining molecular docking calculations and experimental verification of biochemical interference, we selected some potential inhibitors of microsomal prostaglandin E2 synthase (mPGES)-1. Starting from low affinity natural product 1, by our combined approach we identified the compounds 19 and 20 with biological activity in the low micromolar range. Our data suggest that the 2,3-dihydrobenzofuran derivatives might be suitable bioinspired lead compounds for development of new generation mPGES-1 inhibitors with increased affinity.