Search results for "IL-38"

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Interleukin-36α axis is modulated in patients with primary Sjögren's syndrome.

2015

Summary The aim of this study was to investigate the expression of the interleukin (IL)-36 axis in patients with primary Sjögren's syndrome (pSS). Blood and minor labial salivary glands (MSG) biopsies were obtained from 35 pSS and 20 non-Sjögren's syndrome patients (nSS) patients. Serum IL-36α was assayed by enzyme-linked immunosorbent assay (ELISA). IL-36α, IL-36R, IL-36RA, IL-38, IL-22, IL-17, IL-23p19 and expression in MSGs was assessed by reverse transcription–polymerase chain reaction (RT–PCR), and tissue IL-36α and IL-38 expression was also investigated by immunohistochemistry (IHC). αβ and γδ T cells and CD68+ cells isolated from MSGs were also studied by flow cytometry and confocal …

MaleReceptors Antigen T-Cell alpha-betaT-LymphocytesSalivary GlandsIL-36aIL-36a IL-38 IL36RA Sjogren's syndrome γδT cellsImmunology and AllergyMedicinemedicine.diagnostic_testSalivary glandbiologyCD68γδT cellsInterleukin-17TranslationalIL-36a; IL-38; IL36RA; Sjögren's syndrome; γδ T cellsInterleukinReceptors Antigen T-Cell gamma-deltaMiddle Agedmedicine.anatomical_structureSjogren's SyndromeImmunohistochemistryFemaleSjögren's syndromeInterleukin 17Signal TransductionAdultmedicine.medical_specialtyCD3ImmunologyPrimary Cell CultureAntigens Differentiation Myelomonocyticγδ T cellsIL36RAFlow cytometrystomatognathic systemAntigens CDInternal medicineHumansbusiness.industryInterleukinsReceptors InterleukinIL-38stomatognathic diseasesSettore MED/16 - ReumatologiaEndocrinologyGene Expression RegulationCell cultureCase-Control StudiesImmunologybiology.proteinInterleukin-23 Subunit p19businessInterleukin-1
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