Search results for "IMMUNOLOGY"

Nondietary therapies for celiac disease.

2012

Currently, the only available therapy for celiac disease is strict lifelong adherence to a gluten-free diet (GFD). Although safe and effective, the GFD is not ideal. It is frequently expensive, of limited nutritional value, and not readily available in many countries. Consequently, a need exists for novel, nondietary therapies for celiac disease. Based on the current understanding of celiac disease pathogenesis, several potential targets of therapeutic intervention exist. These novel strategies provide promise of alternative, adjunctive treatment options but also raise important questions regarding safety, efficacy, and monitoring of long-term treatment effect.

Epidemiology of pediatric tumors of the central nervous system.

2009

Tumors of the CNS are the second most frequent malignancy in childhood and the most common of the solid tumors. An increase in CNS tumor rates during the past decades has been observed in a number of countries. One possibility is that improvements in diagnostics of CNS tumors contributed to the increasing trend. Another concern is that changes in environmental exposures may be responsible for the increasing incidence rates and a number of epidemiologic studies investigated factors like exposure to ionizing radiation, electromagnetic fields, or pesticides. In addition, prenatal exposures, for example from maternal diet, or the role of infectious agents were of particular interest. In this re…

Cytomegalovirus disappearance after treatment for refractory ulcerative colitis in 2 patients treated with infliximab and 1 patient with leukapheresis

2009

AB0996 Rheumathologic Diseases in Adolescence: Psychological Profile of a Difficult Age

2015

Background Chronic disease significantly interfere with the quality of life at every age, expecially in a period of life characterized by the need to assume a role in the society and the research of a specific identity. The personal image is often destroyed by the disease, the long term sequelae of pharmacological treatment. Adolescents are frequently obligated to quit many possibilities of experience with peers. Objectives We realized a plurispecialistic approach to adolescents with rheumatologic diseases, with the figures of neuropsychiatric, psychologists, rheumatologists, endocrinologists, to give an answer to the complex requests of these patients. Methods We evaluated 20 patients with…

The heart in rheumatoid arthritis: contrasting or misleading data from clinical research? Comment on the article by Giles et al

2010

Musculoskeletal manifestations of childhood cancer and differential diagnosis with juvenile idiopathic arthritis (ONCOREUM): a multicentre, cross-sec…

2021

Summary Background Presenting symptoms of childhood cancers might mimic those of rheumatic diseases. However, the evidence available to guide differential diagnosis remains scarce. Preventing wrong or delayed diagnosis is therefore important to avoid incorrect administration of glucocorticoid or immunosuppressive therapy and worsening of prognosis. As such, we aimed to assess the prevalence and characteristics of presenting musculoskeletal manifestations in patients at cancer onset and to identify the factors that differentiate childhood malignancies with arthropathy from juvenile idiopathic arthritis. Methods We did a multicentre, cross-sectional study at 25 paediatric haemato-oncology cen…

SAT0136 Focus on Implementation of Cardiovascular Risk Factor Recording for Patients with Rheumatoid Arthritis in A Rheumatology Outpatient Clinic

2014

Objectives There is a need for implementing the knowledge of cardiovascular (CV) risk in patients with rheumatoid arthritis (RA) into clinical practice. Our aim was to evaluate CV risk factor (CVRF) recording in a rheumatology outpatient clinic (ROC), where the standard was annual CVRF recording. A second aim was to compare CVRF recording between a regular ROC (RegROC) and an arthritis clinic (AC), which consisted of a structured, team-based model. Methods In 2012, 1142 RA patients visited the ROC of the Hospital of Southern Norway. Of these 612 attended RegROC and 530 attended AC. We conducted a search in the patients9 hospital records to identify recording of CVRFs. Results CVRFs were rec…

Plasticizer detection in urine samples after autologous blood transfusion

2012

Azacitidine-Containing Induction Regimens Followed by Azacitidine Maintenance Therapy in High Risk Acute Myeloid Leukemia: First Results of the Rando…

2012

Abstract Abstract 412 Background: A large proportion of patients are currently not eligible for genotype-adapted strategies in acute myeloid leukemia (AML), in particular those lacking specific genetic aberrations such as PML-RARA, CBFB-MYH11, RUNX1-RUNX1T1, NPM1 or activating FLT3 mutations. This subgroup of patients accounts for about one-third of all AML patients and mainly includes the large group of AML with myelodysplasia-related changes, AML with recurrent cytogenetic abnormalities [inv(3) or t(3;3), t(9;11), t(v;11q23)] and cytogenetically normal AML (CN-AML) with wild-type NPM1 and FLT3. Prognosis in this subgroup of patients is generally poor. Azacitidine has been shown to be acti…

Frequency of thrombosis is higher in MPN patients who develop second cancer than in controls

2019

Introduction Malignancy can be heralded by unprovoked venous thromboembolism (VTE) but also by arterial thrombosis. To date it is unknown whether this association is present also in myeloproliferative neoplasms (MPN), in which arterial thrombosis is more frequent that venous thrombosis and solid tumors are reported with an increased frequency. The MPN-K nested case-control study addressed the impact of cytoreductive drugs on the risk of developing second cancer in MPN patients (Barbui T et al, Leukemia 2019); here we re-examined the study database to evaluate the frequency and type of vascular complications in MPN patients with second cancer excluding leukemia and to establish whether arter…