Search results for "IMPAIRMENT"

Clinical-anatomical correlation in a selective phonemic speech production impairment

2004

Although phonemic paraphasias are common in aphasic disorders, including Broca's aphasia, conduction aphasia and transcortical motor aphasia, selective phonemic speech production impairment, or phonemic disintegration, is unusual. A patient with a selective phonemic speech production disorder underwent clinical, neuropsychological and structural neuroradiological assessment over a period of 6 years. The disorder was characterised by phonemic paraphasias (phonemic disintegration) with preserved comprehension and naming. Imaging showed a focal lesion in the white matter of the left precentral gyrus and, to a lesser extent, the posterior part of the left middle frontal gyrus, with overlying co…

TYPE 2 DIABETES AND ALZHEIMER’S DISEASE

2014

Epidemiological and biological evidences support a link between type 2 diabetes mellitus (DM2) and Al-zheimer’s disease (AD). Persons with diabetes have a higher incidence of cognitive decline and an increased risk of developing all types of dementia. Cognitive deficits in persons with diabetes mainly affect the ar-eas of psychomotor efficiency, attention, learning and memory, mental flexibility and speed, and executive function. The strong epidemiological association has suggested the existence of a physiopathological link. The determinants of the accelerated cognitive decline in DM2, however, are less clear. Increased cortical and subcortical atrophy have been evidenced after con-trolling…

MCI ED EVOLUZIONE IN DEMENZA

2010

Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis

2011

Background: Percutaneous endoscopic gastrostomy (PEG) is offered to amyotrophic lateral sclerosis (ALS) patients with severe dysphagia. Immediate benefits of PEG are adequate food intake and weight stabilization. However, the impact of PEG on survival is still uncertain. In this work we retrospectively evaluated the effect of PEG on survival in a cohort of ALS patients followed in a tertiary referral centre. Methods: Between 2000 and 2007, 150 dysphagic ALS patients were followed until death or tracheostomy. PEG was placed in 76 patients who accepted the procedure and survival was analysed using the Kaplan-Meier life-table method. Results: In ALS patients submitted to PEG, no major complica…

COGNITIVE IMPAIRMENT IN PATIENTS WITH PARKINSON’S DISEASE

2011

Vertebral fracture, function and cognitive status in osteoporotic hip fractured women: The FOCUS study

2017

Osteoporosis is characterizated by low bone mass and microarchitectural modifications of bone tissue with a consequent increase in fragility fracture.

Microcephaly a clinical-genetic and neurologic approach

2013

Decreased motor unit firing rate and force control in older men

2006

Introduction Ageing is related to muscle atrophy that leads to decreases in muscle force. The largest changes are found in fast muscle fibres and fast force production, reducing the capability to recover from sudden balance disturbances. Also ageing-related decrease in force control has been found, as indicated by an increase in force fluctuations and motor unit (MU) firing variability (Galganski et al. 1993). Possibly due to differences in measurement protocols and muscles, the results concerning the effects of ageing on motor unit firing rate are, however, somewhat contradictory (for review, see Roos et al. 1997). The purpose of the present study was to investigate the age-related changes…

Age differences in the irrelevant sound effect: A serial recognition paradigm

2015

In adults, the disrupting effect of irrelevant background sounds with distinct temporalspectral variations (changing-state sounds) on short-term memory performance was found to be robust. In the present study, a verbal serial recognition task was used to investigate this so-called Irrelevant Sound Effect (ISE) in adults and 8- to 10-year-old children. An essential part of the short-term memory impairment during changing-state speech is due to interference processes (changing-state effect) which can be differentiated from the deviation effect of auditory distraction. In line with recent findings (Hughes et al., 2013), our study demonstrates that the changing-state effect is not modulated by …

A failure of high level verbal response selection in progressive dynamic aphasia.

2005

Different theoretical interpretations have been offered in order to account for a specific language impairment termed dynamic aphasia. We report a patient (CH) who presented with a dynamic aphasia in the context of nonfluent progressive aphasia. CH had the hallmark of reduced spontaneous speech in the context of preserved naming, reading, and single word repetition and comprehension. Articulatory and grammatical difficulties were also present. CH had a very severe verbal generation impairment despite being able to describe pictorial scenes and action sequences well. In the experimental investigations CH was severely impaired in word, phrase, and sentence generation tasks when many competing…