Search results for "IMPAIRMENT"

PATH56 MRI correlates of vascular cognitive impairment: contribution of microbleeds, white matter changes and infarcts in a large hospital-based cros…

2010

Background The mechanisms underlying vascular cognitive impairment remain poorly understood. Brain microbleeds may contribute, particularly to executive dysfunction. We investigated the cognitive effects of microbleeds and other neuroimaging markers for cerebrovascular disease in a large, hospital-based study. Methods Consecutive, unselected patients referred to the stroke unit or clinic underwent clinical assessment, detailed neuropsychological testing and vascular MRI. Microbleeds, white matter changes (WMC) and brain infarcts were identified and their effects on cognition assessed. Results 242 patients were included (N=60 with, N=182 without microbleeds). Executive impairment was more pr…

Inspiratory Muscle Training Among Frail Elderly People With Functional Impairment

2011

Case report supporting that the Barber-Say and ablepharon macrostomia syndromes could represent one disorder.

2009

We report on a 7-year-old girl with unequivocal features of Barber-Say syndrome (BSS): generalized hypertrichosis especially at the back, dry lax skin, macrostomia, thin lips, cup-shaped ears, bulbous nose, hypoplastic nipples, and abnormal external genitalia. She also demonstrated conductive hearing impairment and microblepharon. BSS has been reported with ectropion (not present in our patient), but ablepharon and microblepharon (i.e., absent or hypoplastic eyelids) have always been considered as hallmarks of ablepharon macrostomia syndrome (AMS). This is the first report of microblepharon in BSS. Other authors have discussed that BSS and AMS could possibly represent one syndrome, and our …

Trunk kinematics during cross country sit-skiing ergometry: Skiing strategies associated to neuromusculoskeletal impairment

2016

Since trunk function plays a major role in propulsion in sit-skiers and athletes belonging to distinct classes have different abilities to control trunk muscles, the aim of this study is to evaluate how athletes personalized their skiing strategy to compensate their impairment and improve skiing effectiveness. Sixteen Paralympic sit-skiers belonging to different classes volunteered as participant. Each athlete executed two double poling tests on a ski ergometer at the maximal speed he/she can reach and the best, identified as the fastest, was considered in the analysis. A set of two passive reflective markers was used for kinematic analysis: the first marker was placed on the athlete should…

Reply to Letter to the Editor “Polypharmacy in elderly people with diabetes admitted to hospital”

2015

P-71ADOLESCENT ETHANOL EXPOSURE INDUCES LONG-TERM MEMORY DEFICITS AND POTENTIATES THE MEMORY IMPAIRMENT INDUCED BY COCAINE WITHDRAWAL IN ADULT MICE

2015

Ethanol (EtOH) heavy-binge drinking during pubertal development elicits long-lasting neurobehavioral alterations in the adulthood such as memory impairments. An early history of EtOH consumption is correlated with higher rates of cocaine addiction in the adulthood. One consequence of cocaine withdrawal is the induction of memory deficits. The aim of the present investigation was to study the consequences of adolescent exposure …

Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown

2020

Objective: The effects of the COVID-19 lockdown on subjects with prodromal phases of dementia are unknown. The aim of this study was to evaluate the motor, cognitive, and behavioral changes during the COVID-19 lockdown in Italy in patients with Parkinson's disease (PD) with and without mild cognitive impairment (PD-MCI and PD-NC) and in patients with MCI not associated with PD (MCInoPD).Methods: A total of 34 patients with PD-NC, 31 PD-MCI, and 31 MCInoPD and their caregivers were interviewed 10 weeks after the COVID-19 lockdown in Italy, and changes in cognitive, behavioral, and motor symptoms were examined. Modified standardized scales, including the Neuropsychiatric Inventory (NPI) and t…

The capacity to consent to treatment in amyotrophic lateral sclerosis: a preliminary report

2020

Background: Facing the relentless worsening of their condition, ALS patients are required to make decisions on treatments and end-of-life care. A cognitive impairment showed to be a negative prognostic factor in ALS patients, perhaps affecting the ability to make informed decisions. Notwithstanding its crucial role, the capacity to consent to treatment (CCT) has never been evaluated in these patients. Objectives: To assess the CCT in an ALS cohort in comparison to a control group, and to study the effects of demographic and clinical variables on this high-level cognitive function. Methods: 102 ALS patients and 106 healthy controls (HC) were enrolled. CCT was assessed using the MacArthur Com…

Neuroanatomical changes in early Parkinson’s disease with mild cognitive impairment: a VBM study; the Parkinson’s Disease Cognitive Impairment Study …

2021

Introduction: Mild cognitive impairment (MCI) is common in Parkinson’s disease (PD), but the underlying pathological mechanism has not been fully understood. Voxel-based morphometry could be used to evaluate regional atrophy and its relationship with cognitive performances in early PD-MCI. Patients and Methods: One hundred and six patients with PD were recruited from a larger cohort of patients, the Parkinson’s Disease Cognitive Impairment Study (PaCoS). Subject underwent a T1-3D MRI and a complete clinical and neuropsychological evaluation. Patients were divided into PD with normal cognition (PD-NC) and PD-MCI according to the MDS level II criteria–modified for PD-MCI. A subgroup of early …

Association Between Fatigue and Cognitive Impairment at 6 Months in Patients With Ischemic Stroke Treated With Acute Revascularization Therapy.

2019

Background: Fatigue is a frequent symptom after stroke. We aimed to determine the association between fatigue and cognitive performance in patients with ischemic stroke who received acute revascularization therapy (IV thrombolysis and/or mechanical thrombectomy).Methods: Seventy patients were prospectively included in the stroke unit of the University Hospital of Dijon, France. A follow-up was performed at 6 months with clinical examination, fatigue assessment by the Fatigue Severity Scale (FSS), and a comprehensive neuropsychological evaluation. Patients with fatigue (FSS score >4) were compared with patients without fatigue. Neuropsychological factors associated with fatigue at 6 month…