Search results for "INDUCTION"

From palliation to cure: PIPAC for peritoneal malignancies

2019

Introduction Systemic chemotherapy offers poor control over peritoneal disease, maybe as a consequence of restricted drug availability within the abdominal cavity. Locoregional chemotherapy may overcome these shortcomings but its administration is limited to a few patients with confined peritoneal spread. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) emerged in the last years as a novel method of intraperitoneal drug administration. Evidence acquisition We report a meta-analysis of published studies on PIPAC safety and pathological anti-tumoral efficacy on PC from various tumor entities, with the aim of providing more evidence to support further research. This systematic review a…

Prediction of Early Death and Severe Infections during Novel Agent-Based Induction Therapy in Newly-Diagnosed Multiple Myeloma: An Intergroup Analysi…

2021

Abstract Background: During the past decade, prognostic tools and outcomes of patients with newly-diagnosed multiple myeloma (NDMM) markedly improved. Data from clinical trials evaluating early morbidity and mortality including patients with transplant-eligible NDMM treated with novel agents are scarce. Thus, we aimed to analyze early morbidity and mortality in this patient cohort, devise and validate a predictive score to identify patients at risk. Patients and methods: Between July 2005 and January 2018, 1333 patients with transplant-eligible NDMM from three subsequent phase III trials, HD4, MM5 and HD6 from the German-speaking Myeloma Multicenter Group (GMMG), received a novel agent-base…

High-risk neuroblastoma: where do we go?

2020

PKP-005 Prognostic impact of novel gene polymorphisms in newly diagnosed acute myeloid leukaemia adults undergoing induction chemotherapy: Abstract P…

2015

Background Single nucleotide polymorphisms (SNPs) could lead to inter-individual differences in treatment outcomes. Purpose A recent study 1 reported several novel SNPs involved in cytarabine cytotoxicity using a whole-genome approach, which were associated with clinical outcomes in a paediatric AML population. However their association with effectiveness and toxicity remain undetermined in adults. Material and methods The six SNPs with clinical significance in the Gamazon study 1 (Table 1) were evaluated in 109 adult patients at initial diagnosis with AML using a mass spectrometry–based multiplex genotyping assay (Sequenom). All patients were treated with idarubicin plus cytarabine. Genoty…

Neoadjuvant chemotherapy for stage IIIA-N2 non-small cell lung cancer

2005

Neoadjuvant chemotherapy in potentially resectable stage IIIA-N2 non-small cell lung cancer (NSCLC) has become standard of treatment in the last years. Two randomised pioneer phase III trials conducted with second generation platinum combinations had demonstrated an advantage in survival of induction chemotherapy followed by surgery versus surgery alone. Subsequently, a wide number of phase II studies with third generation platinum-based doublets or triplets have increased the evidence of the activity as well as the good tolerability of this approach. Nowadays, the main topics of ongoing clinical research are to assess the role of induction chemotherapy in early stage disease, and the role …

Ondansetrón. Un tratamiento satisfactorio para el prurito palmoplantar refractario

2006

Ontology-based multiagent systems using Inductive Recommendations - A new approach to qualify building use during the Design phase

2012

International audience; In this paper we propose a new metamodel to represent data for mutliagent-based simulations. Using this model, we also propose a method to perform the qualification of a building as soon as it is designed. The metamodel relies on semantic structures and allows representing both agents and environment. The representation of the environment use two kind of data: semantic and geometry. The qualification relies, for its part, on reasoning systems.

Analytical and experimental evaluation of a WECS based on a Doubly Fed Induction Generator fed by a matrix converter

2008

In this paper the control of a grid-connected Wind Energy Conversion System (WECS), based on a sensorless vector controlled Doubly-Fed Induction Generator (DFIG) fed by a matrix converter, is presented. The matrix converter is controlled using a space vector modulation algorithm. Stability issues related to the operation of the WECS connected to the grid using a matrix converter are also discussed in this work. The influence of a synchronous rotating filter in the dynamic of the proposed WECS is analysed. A Model Reference Adaptive System (MRAS) observer for sensorless control of the proposed WECS is used in this work. Using the speed estimated by the MRAS observer the electrical torque of …

A Rotor Flux and Speed Observer for Sensorless Single-Phase Induction Motor Applications

2012

It is usual to find single-phase induction motor (SPIM) in several house, office, shopping, farm, and industry applications, which are become each time more sophisticated and requiring the development of efficient alternatives to improve the operational performance of this machine. Although the rotor flux and rotational speed are essential variables in order to optimize the operation of a SPIM, the use of conventional sensors to measure them is not a viable option. Thus, the adoption of sensorless strategies is the more reasonable proposal for these cases. This paper presents a rotor flux and rotational speed observer for sensorless applications involving SPIMs. Computer simulations and the…

Good things never last: dampening positive emotions influences our optimism levels

2016

A pesar del creciente interés en la comprensión de las estrate-gias de regulación emocional (RE) de las emociones positivas y su relación con la salud mental, la relación entre los diferentes estilos de respuesta al afecto positivo y estilos cognitivos como el optimismo aún no se ha proba-do empíricamente. El objetivo del presente estudio fue evaluar el efecto de las estrategias para regular emociones positivas (evaluadas por el cuestiona-rio Response to Positive Affect -RPA) sobre el optimismo, y la posible media-ción del afecto positivo en esta relación. 250 participantes completaron el cuestionario RPA, medidas de optimismo y afecto positivo, y realizaron un procedimiento de inducción em…