Search results for "INFECTION"
showing 10 items of 3717 documents
Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the safe use of three aqueous solutions of hydrogen…
2020
* This record is given in both English and Spanish. The company Peroxychem Spain S.L.U. has requested a safety assessment of the use of three aqueous solutions of hydrogen peroxide, acetic acid and peracetic acid as processing aids. 1-Hydroxy ethylidene-1,1-diphosphonic acid (HEDP) was used as a stabiliser. The proposed use is the antibacterial treatment of water used to wash citrus fruits and peppers in processing plants. When this water is disinfected, it can be reused for the consecutive washing of fruits and vegetables through a recirculating system, maintaining it in appropriate conditions and thus reducing water usage. These are the same aqueous solutions previously assessed by the AE…
Rac1 and PAK1 are upstream of IKK-ε and TBK-1 in the viral activation of interferon regulatory factor-3
2004
The anti-viral type I interferon (IFN) response is initiated by the immediate induction of IFN beta, which is mainly controlled by the IFN-regulatory factor-3 (IRF-3). The signaling pathways mediating viral IRF-3 activation are only poorly defined. We show that the Rho GTPase Rac1 is activated upon virus infection and controls IRF-3 phosphorylation and activity. Inhibition of Rac1 leads to reduced IFN beta promoter activity and to enhanced virus production. As a downstream mediator of Rac signaling towards IRF-3, we have identified the kinase p21-activated kinase (PAK1). Furthermore, both Rac1 and PAK1 regulate the recently described IRF-3 activators, I kappa B kinase- and TANK-binding kina…
Questing abundance of adult taiga ticks Ixodes persulcatus and their Borrelia prevalence at the north-western part of their distribution
2020
Background Because ixodid ticks are vectors of zoonotic pathogens, including Borrelia, information of their abundance, seasonal variation in questing behaviour and pathogen prevalence is important for human health. As ticks are invading new areas northwards, information from these new areas are needed. Taiga tick (Ixodes persulcatus) populations have been recently found at Bothnian Bay, Finland. We assessed seasonal variation in questing abundance of ticks and their pathogen prevalence in coastal deciduous forests near the city of Oulu (latitudes 64–65°) in 2019. Methods We sampled ticks from May until September by cloth dragging 100 meters once a month at eight study sites. We calculated a…
Lack of reactivation of tuberculosis in patients with psoriasis treated with secukinumab in a real-world setting of latent tuberculosis infection
2022
Background Some biologics for psoriasis, especially anti-tumor necrosis factor (TNF)-alpha therapies, may re-activate latent tuberculosis (TBC) infection with consequent morbidity and mortality. However, there is a low reported incidence of conversion to positive TBC status among patients with psoriasis treated with second-generation biologic therapies, particularly anti-interleukin (IL)-17 therapies such as secukinumab. Objectives To evaluate the safety profile of secukinumab in psoriasis patients with latent TBC infection. Methods Real-life data were collected by retrospective chart review on patients with moderate-to-severe psoriasis who showed positivity for TBC screening at baseline an…
La représentation sociale de l'hygiène chez les professionnels de santé : Intérêt du recueil par entretien et de l'analyse discursive des opérateurs …
2009
This study deals with professional representations. The goal is to show the representation of hygiene by health care workers: Nurses (N) and Health Care Aides (HCA). Method follows the BSC (Bases Cognitive Schemes) procedure, explicative interviews substitute to the evaluation task. An analysis of associative words points out that for HCA hygiene is associated with acts linked with corporal hygiene and with two synonymous: no trace, no germ Discussion underlines the interest of this method for professional representations studies and nosocomial infections strength.
Effet des pratiques et des connaissances sur la représentation sociale d'un objet : application à l'hygiène hospitalière
2008
The current study deals with the representation of hospital hygiene. The purpose is twofold: 1- to understand how knowledge about hygiene is acquired by nursing staff during their training (effect of the level of knowledge); 2- to identify how this knowledge evolves while practising a job in direct connection with hygiene (effect of practice). Three groups of participants were questioned: nursing staff (nursing executives, nurses and nursing auxiliaries), students training in nursing care (first, second and third year students) and non-specialist students. The results show that the three groups clearly share a common cultural base. This result confirms the existence of an overall architectu…
Antibiotiku rezistento koagulāzes negatīvo stafilokoku nozīme traumatoloģijas un ortopēdijas slimnīcā
2016
Koagulāzes negatīvie stafilokoki (KoNS) tikai nesen atzīti kā oportūni patogēni. Lai arī to virulences potenciāls ir zems, tie rada raizes jebkuram veselības aprūpes speciālistam. KoNS rezistence pret vairumu antibiotiku to nozīmi padara tikai aktuālāku. Pētījuma mērķis ir noteikt antibiotiku rezistento KoNS nozīmi traumatoloģijā un ortopēdijā un to ietekmi uz veselības aprūpes sistēmu. Šajā pētījumā 82,8% gadījumu KoNS bija multi-antibiotiku rezistenti. Pētījumā tika novērota antibiotiku rezistento KoNS ietekme gan uz pacientu hospitalizācijas laiku, gan palielinātu nepieciešamību veikt ķirurģiskās manipulāciju, kas apliecina to radīto slogu uz veselības aprūpi. Tāpat 74,7% iepriekš infekc…
RSV disease in infants and young children: Can we see a brighter future?
2022
Respiratory syncytial virus (RSV) is a highly contagious seasonal virus and the leading cause of Lower Respiratory Tract Infections (LRTI), including pneumonia and bronchiolitis in children. RSV-related LRTI cause approximately 3 million hospitalizations and 120,000 deaths annually among children <5 years of age. The majority of the burden of RSV occurs in previously healthy infants. Only a monoclonal antibody (mAb) has been approved against RSV infections in a restricted group, leaving an urgent unmet need for a large number of children potentially benefiting from preventive measures. Approaches under development include maternal vaccines to protect newborns, extended half-life monoclon…
Antioxidant Effects of Dietary Supplements on Adult COVID-19 Patients: Why Do We Not Also Use Them in Children?
2022
Respiratory tract infections (RTIs) are very common in children, especially in the first five years of life, and several viruses, such as the influenza virus, Respiratory Syncytial Virus, and Rhinovirus, are triggers for symptoms that usually affect the upper airways. It has been known that during respiratory viral infections, a condition of oxidative stress (OS) occurs, and many studies have suggested the potential use of antioxidants as complementary components in prophylaxis and/or therapy of respiratory viral infections. Preliminary data have demonstrated that antioxidants may also interfere with the new coronavirus 2’s entry and replication in human cells, and that they have a role in …
Lemierre Syndrome associated with dental infections : report of one case and review of the literature
2007
The first publication on Lemierre Syndrome appears in 1936 by Lemierre. It is defined as an ?oropharynx bacterial infection characterized by the thrombophlebitis in the internal jugular vein, derived in a systemic septic embolism?. In 81% of the cases, the Fusobacterium necrophorum is the most frequent etiologic agent. Fever is the most common symptom, but it can depending on the primary infection, tonsillitis, mastoiditis or odontogenic infection. According to the literature the mortality is very low, but with a significant morbidity, that is why the diagnosis and early treatment is very important. The diagnosis it´s clinical, even though the CT scan and other diagnosis methods (echography…