Search results for "INFECTIONS"

showing 10 items of 2671 documents

Validation and clinical use of the CECA, a disease-specific quality of life questionnaire for patients with anogenital Condylomata Acuminata

2008

Journal Article; Multicenter Study; Validation Studies; ECAVIm Study Group: I. Puedo, Centro ETS, Sevilla; J. Ballesteros, Clínica Sandoval, madrid; C. Colomo and A. Comunión, Centro ETS montesa, Madrid; X. Camino, Hospital Donosita, San Sebastián-Donosti; m. T. Arguisjuela, Centro ETS, Sevilla; J. m. Rojo, Hospital de Valme, Sevilla; J. Ferrando and E. barbera, CAP baix Ebre, Tarragona; J. Boronat, Hospital Joan XXIII, Tarragona; P. Herranz, Hospital La Paz, Madrid; M. Sabán, CAP Ronda de Torrasa, Barcelona; A. Sevila, Hospital de San Juan, Alicante; b. Escutia, Hospital de Elda, Alicante; b. Numancia, Centro ETS Ayuntamiento, Zaragoza; M. García Font, Hospital Mútua de Terrassa, Barcelona…

MaleSexually transmitted disease:Named Groups::Persons::Adult Children [Medical Subject Headings]:Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Rectal Diseases::Anus Diseases [Medical Subject Headings]:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineSurveys and Questionnaireswarts:Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases Infectious::Skin Diseases Viral::Warts::Condylomata Acuminata [Medical Subject Headings]030212 general & internal medicineCuestionariosInfecciones por Papillomavirus:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings]General MedicineVerrugas:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Sexual Behavior [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results [Medical Subject Headings]femaleCondylomata AcuminataFemaleGenital Diseases Male0305 other medical sciencepapillomavirus infections:Check Tags [Medical Subject Headings]AdultDisease specificmedicine.medical_specialtyPsychometricsEnfermedades de los genitales masculinosSexual Behavior:Check Tags::Male [Medical Subject Headings]Dermatologygenital diseasespsychology:Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Psychometrics [Medical Subject Headings]03 medical and health sciencesmaleEnfermedades de los genitales femeninosmedicineHumans:Humanities::Humanities::Philosophy::Life::Quality of Life [Medical Subject Headings]Human papillomavirusEnfermedades del ano:Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases Female [Medical Subject Headings]:Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Skin Diseases Infectious::Skin Diseases Viral::Warts [Medical Subject Headings]Anus Diseases030505 public healthCondiloma acuminadobusiness.industry:Diseases::Male Urogenital Diseases::Genital Diseases Male [Medical Subject Headings]Reproducibility of ResultsquestionnairesPsicologíaSurgeryquality of life:Diseases::Virus Diseases::Tumor Virus Infections::Papillomavirus Infections [Medical Subject Headings]Quality of LifeCalidad de Vidabusiness:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Psychology Social [Medical Subject Headings]Genital Diseases FemaleHumanities
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Vaccination against HPV-Associated Neoplasias

2014

Neoplasias associated with anogenital human papilloma viruses (HPV) are characterised by high patient morbidity and mortality and by appreciable limitations in the patientʼs quality of life. Each year 530,000 women worldwide and 4800 women in Germany develop cervical cancer 1, 2. Biomolecular and epidemiological studies carried out in the past 25 years have demonstrated causal link between persisting infections with HPV 16 and HPV 18 and at least 11 other so-called high-risk HPVs (HR-HPVs) and the development of cervical cancer and its precursor lesions (so-called dysplasias or, respectively, cervical intraepithelial neoplasias – CIN). HPV 16, HPV 18 and other HR-HPVs are also the causes of…

MaleSexually transmitted diseasemedicine.medical_specialtyGenital Neoplasms FemaleImmunization SecondaryMedizinHPV vaccinesGermanyMaternity and MidwiferymedicineHumansPenile cancerPapillomavirus VaccinesCervixGynecologyCervical cancerDose-Response Relationship Drugbusiness.industryPapillomavirus Infectionsvirus diseasesObstetrics and GynecologyGuidelinemedicine.diseaseDermatologyfemale genital diseases and pregnancy complicationsVaccinationmedicine.anatomical_structureGenital Neoplasms MaleFemaleSkin cancerbusiness
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Simvastatin Inhibits Inflammatory Properties ofStaphylococcus aureusα-Toxin

2002

Background—Simvastatin, a 3-hydroxy-methylglutaryl coenzyme A reductase inhibitor, has been shown to lower serum cholesterol levels in clinical use. Moreover, statins exert beneficial effects in vascular diseases by inhibition of leukocyte rolling, adherence, and transmigration. The aim of this study was to determine if pretreatment with simvastatin attenuatesStaphylococcus aureusα-toxin–induced increase in leukocyte-endothelial interactions during exotoxemia.Methods and Results—The effects of simvastatin on leukocyte-endothelial cell interactions were observed by intravital microscopy in the rat mesenteric microcirculation. Simvastatin (50 or 100 μg/kg) was administered 18 hours before the…

MaleSimvastatinNitric Oxide Synthase Type IIIP-selectinEndotheliumBacterial ToxinsToxemiaInflammationLeukocyte RollingPharmacologyMicrocirculationRats Sprague-DawleyHemolysin ProteinsMesenteric VeinsVenulesCell MovementCulture TechniquesPhysiology (medical)Cell AdhesionLeukocytesmedicineAnimalsMicroscopy Videobusiness.industryAnti-Inflammatory Agents Non-SteroidalHemodynamicsStaphylococcal InfectionsImmunohistochemistryRatsEndothelial stem cellP-Selectinmedicine.anatomical_structureSimvastatinImmunologyEndothelium VascularHydroxymethylglutaryl-CoA Reductase InhibitorsNitric Oxide Synthasemedicine.symptomCardiology and Cardiovascular MedicinebusinessIntravital microscopymedicine.drugCirculation
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Leg ulcer and osteomyelitis due to methicillin-susceptible Staphylococcus aureus infection after fracture repair treatment: a case highlighting the p…

2015

Prostaglandins appear to reduce biofilm formation and chronicization of infections, and stimulate a rapid and effective clearance of infecting micro-organisms. We report a case of recovery from methicillin-susceptible Staphylococcus aureus (MSSA) osteomyelitis after multidisciplinary management with antibiotics, anti-thrombotics and prostaglandin E1 (PGE1) vasodilator, in a patient with tibial plateau fracture repaired with internal fixation devices. A 47-year-old HIV-negative male with chronic ulcer on the proximal third of the left leg was admitted to the Orthopaedic Unit of the Orestano Clinic in Palermo, Italy, for suspected osteomyelitis. A biopsy of the skin ulcer and blood cultures w…

MaleStaphylococcus aureusSettore MED/17 - Malattie InfettiveVasodilator AgentsLeg UlcerOsteomyelitisMiddle AgedStaphylococcal InfectionsAnti-Bacterial AgentsTibial FracturesMethicillinTreatment OutcomeFibrinolytic AgentsOrthopaedic Implant-Related Infection MSSA osteomyelitis prostaglandin E1 vasodilatorRisk FactorsHumansDrug Therapy CombinationAlprostadilGentamicinsLe infezioni in medicina
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Bone marrow failure by cytomegalovirus is associated with an in vivo deficiency in the expression of essential stromal hemopoietin genes.

1997

Bone marrow (BM) failure associated with cytomegalovirus (CMV) infection is a feared complication after clinical BM transplantation. Experiments in long-term BM cultures have indicated that BM stromal cells (BMSC) are targets of productive CMV infection, but an in situ infection of BM stroma remained to be documented, and the pathomechanism is open to question. Here we describe a murine in vivo model of lethal CMV aplastic anemia (CMV-AA). The reconstitution of hematopoietic progenitor cells expressing stem cell factor (SCF) receptor was found to be defective in CMV-AA. While murine CMV replication in permissive parenchymal tissues is cytolytic, the hematopoietic cord was found to be a site…

MaleStromal cellImmunologyGene ExpressionStem cell factorBiologyHematopoietic Cell Growth FactorsMicrobiologyMiceBone MarrowVirologyGranulocyte Colony-Stimulating FactormedicineAnimalsRNA MessengerAplastic anemiaMice Inbred BALB CStem Cell FactorInterleukin-6Hematopoietic Cell Growth FactorsBone marrow failureAnemia Aplasticmedicine.diseaseHematopoiesisTransplantationHaematopoiesisProto-Oncogene Proteins c-kitmedicine.anatomical_structureInsect ScienceImmunologyCytomegalovirus InfectionsFemaleBone marrowResearch Article
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CD8 T cell-evasive functions of human cytomegalovirus display pervasive MHC allele specificity, complementarity, and cooperativity.

2014

Abstract Immunoevasive proteins (“evasins”) of human CMV (HCMV) modulate stability and localization of MHC class I (MHC I) molecules, and their supply of antigenic peptides. However, it is largely unknown to what extent these evasins interfere with recognition by virus-specific CD8 T cells. We analyzed the recognition of HCMV-infected cells by a panel of CD8 T cells restricted through one of nine different MHC I allotypes. We employed a set of HCMV mutants deleted for three or all four of the MHC I modulatory genes US2, US3, US6, and US11. We found that different HCMV evasins exhibited different allotype-specific patterns of interference with CD8 T cell recognition of infected cells. In con…

MaleT cellvirusesImmunologyCD1CytomegalovirusCD8-Positive T-LymphocytesMajor histocompatibility complexCell LineAntigenMHC class ImedicineImmunology and AllergyCytotoxic T cellHumansAntigens ViralAllelesImmune EvasionGeneticsAntigen PresentationbiologyHistocompatibility Antigens Class IMHC restrictionCell biologymedicine.anatomical_structureCytomegalovirus Infectionsbiology.proteinFemaleCD8Journal of immunology (Baltimore, Md. : 1950)
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Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines

2015

CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells typically recognize peptides associated to classical MHC class Ia molecules, but little information is available on CD8 T cells recognizing M. tuberculosis Ags presented by nonclassical MHC class Ib molecules. We show here that CD8 T cells from tuberculosis (TB) patients recognize HLA-E-binding M. tuberculosis peptides in a CD3/TCR αβ mediated and CD8-dependent manner, and represent an additional type of effector cells playing a role in immune response to M. tuberculosis during active infection. HLA-E-restricted recognition of M. tuberculosis peptides is detectab…

MaleTetramersCytotoxicHLA-EReceptors Antigen T-Cell alpha-betaT-LymphocytesEpitopes T-LymphocyteHIV InfectionsMycobacterium tuberculosiEpitopesHLA-EReceptorsImmunology and AllergyCells CulturedType 2 cytokinealpha-betaCulturedbiologyCoinfectionType 2 cytokinesMedicine (all)BacterialMiddle AgedAcquired immune systemAntibodies Bacterialmedicine.anatomical_structureTBAntigenCytokinesFemaleNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DCD8 T lymphocyteProtein BindingAdultTuberculosisSettore MED/17 - Malattie InfettiveT cellCellsImmunologyAntibodiesMycobacterium tuberculosisImmune systemAntigenMHC class ImedicineHumansTuberculosisAntigensSettore MED/04 - Patologia GeneraleAntigens BacterialCD8 T lymphocytes; HLA-E; Mycobacterium tuberculosis; TB; Tetramers; Type 2 cytokines; Adult; Antibodies Bacterial; Antigens Bacterial; Cells Cultured; Coinfection; Cytokines; Epitopes T-Lymphocyte; Female; HIV Infections; Histocompatibility Antigens Class I; Humans; Male; Middle Aged; Mycobacterium tuberculosis; NK Cell Lectin-Like Receptor Subfamily C; NK Cell Lectin-Like Receptor Subfamily D; Protein Binding; Receptors Antigen T-Cell alpha-beta; T-Lymphocytes Cytotoxic; Tuberculosis; Immunology; Immunology and Allergy; Medicine (all)Histocompatibility Antigens Class IMycobacterium tuberculosismedicine.diseasebiology.organism_classificationT-CellVirologyCD8 T lymphocytesT-LymphocyteImmunologybiology.proteinTetramerT-Lymphocytes CytotoxicCD8 T lymphocytes; HLA-E; Mycobacterium tuberculosis; TB; Tetramers; Type 2 cytokines; Immunology; Immunology and Allergy
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Genotypic resistance profiles associated with virological failure to darunavir-containing regimens: a cross-sectional analysis.

2012

Introduction: This study aimed at defining protease (PR) resistance mutations associated with darunavir (DRV) failure and PR resistance evolution at DRV failure in a large database of treatment-experienced human immunodeficiency virus (HIV) patients. Results: Overall, 1,104 patients were included: 118 (10.7%) failed at a median observation time of 16 months. The mean number of PR mutations at baseline was 2.7, but it was higher in patients who subsequently failed DRV. In addition, the number of PR mutations increased at failure. The increase in the mean number of mutations was completely related to mutations considered to be associated with DRV resistance following the indications of the ma…

MaleTime FactorsCross-sectional studyHuman immunodeficiency virus (HIV)Drug ResistanceHIV InfectionsDrug resistancemedicine.disease_causeCohort StudiesAntiretroviral Therapy Highly ActiveRitonavir-boosted darunavirGenotypeHIV InfectionTreatment FailureViralGenotypic resistanceDarunavirSulfonamidesGeneral MedicineMiddle AgedVirological failureInfectious DiseasesFemaleHumanmedicine.drugAdultMicrobiology (medical)Logistic ModelTime FactorGenotypeAntiretroviral TherapySettore MED/17 - MALATTIE INFETTIVESulfonamideDrug Resistance ViralmedicineHumansHighly ActiveDarunavir; Genotypic resistance; Protease inhibitors; Ritonavir-boosted darunavir; Adult; Antiretroviral Therapy Highly Active; Cohort Studies; Cross-Sectional Studies; Female; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Logistic Models; Male; Middle Aged; Mutation; Sulfonamides; Time Factors; Treatment Failure; Drug Resistance Viral; Microbiology (medical); Infectious DiseasesHIV Protease InhibitorDarunavirCross-Sectional Studiebusiness.industryHIV Protease InhibitorsProtease inhibitorsAntiretroviral therapyVirologyCross-Sectional StudiesLogistic ModelsProtease inhibitorMutationGenotypic resistanceHIV-1Cohort Studiebusiness
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Efficacy of immunoglobulins in gram-negative infections in experimentally induced peritonitis in the rat

1985

The effect of adjuvantly administered, newly developed immunoglobulin preparations in combination with an antibiotic is investigated by means of an animal experimental model. The animal model was peritonitis which was induced by a left-open colotomy in the rat. Administration of a combination therapy of immunoglobulins and an antibiotic succeeded in reducing lethality and shock index (according to Staub [15]) significantly by up to 50% as compared to the untreated control group. Using sub-therapeutic dosage of the antibiotic (50% of the human equivalent dose) the synergistic effect of the immunoglobulins could be confirmed clearly. A single summation of the offered immunoglobulin preparatio…

MaleTime FactorsGram-negative bacteriaCombination therapymedicine.drug_classmedicine.medical_treatmentAntibioticsPeritonitisPeritonitisPharmacologyImmunoglobulin EGram-Negative BacteriamedicineAnimalsLungChemotherapybiologybusiness.industryImmunization PassiveDrug SynergismBacterial InfectionsOrgan SizeGeneral MedicineImmunotherapybiology.organism_classificationmedicine.diseaseAnti-Bacterial AgentsRatsImmunologybiology.proteinAntibodybusinessResearch in Experimental Medicine
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EFFECT OF TRIAENOPHORUS CRASSUS (CESTODA) INFECTION ON BEHAVIOR AND SUSCEPTIBILITY TO PREDATION OF THE FIRST INTERMEDIATE HOST CYCLOPS STRENUUS (COPE…

2000

Some parasites have been shown to manipulate host behavior so that parasite transmission to the next host is enhanced. Infection with Triaenophorus crassus Forel (Cestoda) caused alterations in the activity and microhabitat selection of the first intermediate host Cyclops strenuus Fischer (Copepoda) in the laboratory. Infected copepods made more starts to swim but spent less time swimming than uninfected copepods. These changes were independent of the intensity of infection. In a water column illuminated from above, infected copepods approached the surface, whereas uninfected ones remained close to the bottom. In the dark both infected and uninfected copepods stayed near the bottom. Finally…

MaleTime FactorsLightCestodaZoologyDisease VectorsMotor ActivityHost-Parasite InteractionsFish DiseasesfoodCoregonus lavaretusCrustaceaAnimalsHelminthsParasite hostingSwimmingEcology Evolution Behavior and SystematicsInfectivityAnalysis of VarianceBehavior Animalbiologyfood.dishHost (biology)EcologyIntermediate hostCestode Infectionsbiology.organism_classificationCrustaceanPhotobiologyPredatory BehaviorCestodaFemaleParasitologyhuman activitiesSalmonidaeJournal of Parasitology
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