Search results for "INFORMATICS"
showing 10 items of 2542 documents
Designing de novo: interdisciplinary debates in synthetic biology
2013
Synthetic biology is often presented as a promissory field that ambitions to produce novelty by design. The ultimate promise is the production of living systems that will perform new and desired functions in predictable ways. Nevertheless, realizing promises of novelty has not proven to be a straightforward endeavour. This paper provides an overview of, and explores the existing debates on, the possibility of designing living systems de novo as they appear in interdisciplinary talks between engineering and biological views within the field of synthetic biology. To broaden such interdisciplinary debates, we include the views from the social sciences and the humanities and we point to some fu…
The reporting of study and population characteristics in degenerative cervical myelopathy: A systematic review
2017
OBJECT: Degenerative cervical myelopathy [DCM] is a disabling and increasingly prevalent condition. Variable reporting in interventional trials of study design and sample characteristics limits the interpretation of pooled outcomes. This is pertinent in DCM where baseline characteristics are known to influence outcome. The present study aims to assess the reporting of the study design and baseline characteristics in DCM as the premise for the development of a standardised reporting set. METHODS: A systematic review of MEDLINE and EMBASE databases, registered with PROSPERO (CRD42015025497) was conducted in accordance with PRISMA guidelines. Full text articles in English, with >50 patients (p…
One is not enough: On the effects of reference genome for the mapping and subsequent analyses of short-reads.
2020
Mapping of high-throughput sequencing (HTS) reads to a single arbitrary reference genome is a frequently used approach in microbial genomics. However, the choice of a reference may represent a source of errors that may affect subsequent analyses such as the detection of single nucleotide polymorphisms (SNPs) and phylogenetic inference. In this work, we evaluated the effect of reference choice on short-read sequence data from five clinically and epidemiologically relevant bacteria (Klebsiella pneumoniae, Legionella pneumophila, Neisseria gonorrhoeae, Pseudomonas aeruginosa and Serratia marcescens). Publicly available whole-genome assemblies encompassing the genomic diversity of these species…
Seven Mathematical Models of Hemorrhagic Shock
2021
Although mathematical modelling of pressure-flow dynamics in the cardiocirculatory system has a lengthy history, readily finding the appropriate model for the experimental situation at hand is often a challenge in and of itself. An ideal model would be relatively easy to use and reliable, besides being ethically acceptable. Furthermore, it would address the pathogenic features of the cardiovascular disease that one seeks to investigate. No universally valid model has been identified, even though a host of models have been developed. The object of this review is to describe several of the most relevant mathematical models of the cardiovascular system: the physiological features of circulator…
Cancer: Clinical Background and Key Challenges
2011
This chapter is aimed at a wide audience ranging from biologists to medical students and cancer specialists. It provides a comprehensive overview of systems approaches to the pathology and treatment of cancer. In particular, it addresses diagnosis and therapy by interconnecting various aspects of cancer at both the molecular and clinical level, and contrasts the unifying features of malignancies with the daunting diversity of cancer types, stages, and evolutionary processes during treatment. The importance is emphasized of both prevention and innovative treatments in reducing the cancer burden, and of early detection as the link between these two major areas. It sets the stage for analysis …
epiModel: A system to build automatically systems of differential equations of compartmental type-epidemiological models
2011
In this paper we describe epiModel, a code developed in Mathematica that facilitates the building of systems of differential equations corresponding to type-epidemiological linear or quadratic models whose characteristics are defined in text files following an easy syntax. It includes the possibility of obtaining the equations of models involving age and/or sex groups. © 2011.
Steering Institutionalization through Institutional Work: The Case of an eProcurement System in Indonesian Local Government
2014
Corruption is arguably one of the main hindrances to development. In their effort to combat corruption, governments in developing countries turn to information technology to enhance transparency in decision making. However, implementation of an information system in this context is not straightforward. Premised upon institutional theory, this interpretive case study traces the role of institutional actors in the institutionalization of an eProcurement system in Indonesian local government. It draws on different streams of research on institutional work to develop an interpretive lens to understand what institutional actors do to steer the institutionalization process. It identifies a set of…
Koettuun informaatioteknologian hyödyllisyyteen vaikuttavat tekijät hoitotyöntekijöillä
2015
Terveydenhuoltoon suunnattu informaatioteknologia on lisääntynyt viimeisten vuosien aikana merkittävästi ja sen odotetaan lisääntyvän edelleen. Teknologian käyttöä kuvaavan TAM-mallin mukaan koetulla hyödyllisyydellä on suora yhteys teknologian käyttöön. Koetun hyödyllisyyden on todettu myös olevan terveydenhuollossa muita toimialoja merkityksellisempi tekijä teknologian käytön selittäjänä. Tämän tutkimuksen tarkoituksena oli selvittää tekijöitä, jotka selittävät hoitohenkilöstön kokemaan teknologian hyödyllisyyttä. Tutkimusaineisto kerättiin kolmen sairaanhoitopiirin alueelta hoitohenkilöstölle suunnatulla verkkokyselyllä. Verkkokyselyn vastaamisen aloitti kaikkiaan 359 henkilöä, joista ai…
Non-invasive localization of atrial ectopic beats by using simulated body surface P-wave integral maps
2017
Non-invasive localization of continuous atrial ectopic beats remains a cornerstone for the treatment of atrial arrhythmias. The lack of accurate tools to guide electrophysiologists leads to an increase in the recurrence rate of ablation procedures. Existing approaches are based on the analysis of the P-waves main characteristics and the forward body surface potential maps (BSPMs) or on the inverse estimation of the electric activity of the heart from those BSPMs. These methods have not provided an efficient and systematic tool to localize ectopic triggers. In this work, we propose the use of machine learning techniques to spatially cluster and classify ectopic atrial foci into clearly diffe…
Ventricular Fibrillation and Tachycardia detection from surface ECG using time-frequency representation images as input dataset for machine learning
2017
Parameter-less ventricular fibrillation detection with time-frequency representation.Time-frequency representations are treated as images for a classifier.A comparison for four classifiers demonstrates the validity of the proposed method.The proposed technique could be applied to any signal and research field.This is a novel approach to signal analysis. Background and objectiveTo safely select the proper therapy for Ventricullar Fibrillation (VF) is essential to distinct it correctly from Ventricular Tachycardia (VT) and other rhythms. Provided that the required therapy would not be the same, an erroneous detection might lead to serious injuries to the patient or even cause Ventricular Fibr…