Search results for "INHIBITION"
showing 10 items of 590 documents
Activity level in left auditory cortex predicts behavioral performance in inhibition tasks in children
2022
Funding Information: We are grateful to Hanna-Maija Lapinkero, Suvi Karjalainen, Maria Vesterinen & Janne Rajaniemi for help with data collection and to Amit Jaiswal, Erkka Heinilä and Jukka Nenonen for their help with preprocessing and scripting. This work was supported by EU project ChildBrain (Horizon2020 Marie Skłodowska-Curie Action (MSCA) Innovative Training Network (ITN) – European Training Network (ETN), grant agreement no. 641652) and the Academy of Finland grant number 311877. Publisher Copyright: © 2022 Sensory processing during development is important for the emerging cognitive skills underlying goal-directed behavior. Yet, it is not known how auditory processing in children is…
Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats
2023
Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and more inflammation in the hippocampus and perform worse than rats bred for a High Capacity for Running (HCR) in tasks requiring flexible cognition. Here we used middle-aged (∼ 16 months) HCR and LCR rats to study how genotype and sex associate with anxiety and neural information filt…
Modelling of the cometabolic decomposition of 4-chlorophenol and phenol by the Stenotrophomonas maltophilia KB2 strain
2017
Zaprezentowano model rozkładu 4-chlorofenolu przez szczep Stenotrophomonas maltophilia KB2 w obecności fenolu jako substratu wzrostowego. Opracowanie tego modelu wymagało wykonania czterech serii badań: biodegradacji różnych dawek czystego fenolu, biodegradacji różnych dawek czystego 4-CP, biodegradacji 4-CP w obecności fenolu przy różnym stosunku stężeń obu substratów oraz biodegradacji 4-CP przez komórkiw fazie spoczynku, indukowane wstępnie fenolem. Szczegółowo omówiono sposoby wyznaczania poszczególnych parametrów równań opisujących szybkość degradacji substratów wzrostowego i niewzrostowego oraz przyrostu biomasy. W oparciu o stworzoną bazę danych obliczono m.in. stałe półnasycenia KSg…
Enzyme Inhibition Microassays on Blu-Ray Disks for Drug Discovery
2019
[EN] An enzyme inhibition-based assay for drug discovery developed by microarraing on Blu-ray disks is presented. As a proof-of-concept, the system screens a selected molecule library of potential chemical inhibitors against the glycoenzyme peroxidase, identifying the promising lead compounds with high selectivity using standard Blu-ray disks and drives. In order to face the first drug discovery stages, we establish the bases for a high-throughput screening assay and a methodology based on hypersurfaces suitable to manage a high number of data as well.
Green approach to corrosion inhibition of stainless steel in phosphoric acid of Artemesia herba albamedium using plant extract
2019
Essential oil from aerial parts of Artemisia herba-alba from Morocco was hydrodistilled and its chemical composition oil was investigated by capillary GC and GC/MS. The major components were 1,8-cineole (35.6%) and camphor (24.1%). Artemisia herba-alba essential oil AHAO was tested as corrosion inhibitor of stainless steel (SS) in 1M H3PO4 using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy measurements (EIS) and scanning electronically microscopy (SEM) studies. The results obtained showed that the essential oil of Artemisia reduces the corrosion rate. Tafel polarization method indicates that the plant extract behaves as a mixed type inhibitor. The inhibition…
Possible Contribution of T-pattern Detection and Analysis to the Study of the Behavioral Correlates of Afferent Inhibition.
2020
A pivotal tenet in modern behavioral sciences is that the study of behavior, in its most intimate structure, necessarily deals with time and, for this reason, behavioral dynamics are not intuitively perceivable and/or detectable (Eibl-Eibesfeldt, 1970). In reality, the possibility to describe a given behavior in terms of its structural/temporal features makes available new and detailed information otherwise unavailable. The aim of the present paper is to discuss the possible application of T-pattern detection and analysis, i.e., a multivariate approach specifically developed to describe the temporal structure of behavior, to the study of an important and still scantly investigated issue, na…
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Beta-band MEG signal power changes in older adults after physical exercise program with and without additional cognitive training
2023
Physical exercise has been considered to be an efficient mean of preserving cognitive function and it influences both the structural and functional characteristics of the brain. It has especially been shown to increase brain plasticity, the capacity to re-structure brain properties in response to interaction, such as cognitive practice. Studies have also examined the potential additive effect of cognitive training on the documented benefit of physical exercise, commonly, however, not at the neural level. We monitored, using magnetoencephalography (MEG), the brain processes associated with executive functions in older individuals who participated in a 12-month randomized controlled trial inc…
Biogas production from ensiled maize with and without hydrothermal pretreatment
2010
Energy crops are suitable substrates for anaerobic digestion. In the future their use will probably increase, and among other things optimum storage and pretreatment technologies should be developed. In this study eight maize silage varieties grown in Piikkiö, Southern Finland were used as substrates in anaerobic digestion. Also hydrothermal pretreatment was used to improve the biogas yield. Composition of the maize silage and the pretreated maize silage were analyzed and inhibitors were analyzed from the pretreated maize silage. The maize silages produce methane as much as fresh maizes in previous studies, when losses during the ensiling are taking into account and even 25-50 % more when l…
Plasma membrane glycoproteins covalently bound to silica beads as a model for molecular studies of cell-cell interactions in culture.
1987
Abstract In previous studies, we have shown that plasma membrane glycoproteins are of major importance in the density-dependent regulation of growth of normal diploid fibroblasts. Due to the hydrophobic portions of these molecules, functional studies in cell culture are often diffucult to perform and to interpret. Specially, the addition of these molecules in soluble form to cell culture, after depletion of detergents needed for their solubilization, leads to aggregation and internalization. Therefore, we developed a method for the covalent immobilization of the solubilized plasma membrane proteins to derivatized silica beads for further investigations on the molecular nature of the active …