Search results for "INMA"
showing 10 items of 87 documents
Surrounding Greenness and Pregnancy Outcomes in Four Spanish Birth Cohorts
2012
Background: Green spaces have been associated with improved physical and mental health; however, the available evidence on the impact of green spaces on pregnancy is scarce. Objectives: We investigated the association between surrounding greenness and birth weight, head circumference, and gestational age at delivery. Methods: This study was based on 2, 393 singleton live births from four Spanish birth cohorts (Asturias, Gipuzkoa, Sabadell, and Valencia) located in two regions of the Iberian Peninsula with distinct climates and vegetation patterns (2003–2008). We defined surrounding greenness as average of satellite-based Normalized Difference Vegetation Index (NDVI) (Landsat 4–5 TM data at …
Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat
2020
Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially when combined with complementary stimulation and recording techniques. The echo planar imaging (EPI) pulse sequence is the most common choice for fMRI investigations, but it has several shortcomings. EPI is one of the loudest sequences and very prone to movement and susceptibility-induced artefacts, making it suboptimal for awake imaging. Additionally, the fast gradient-switching of EPI induces disrupting currents in simultaneous electrophysiological recordings. Therefore, we investigated whether the unique features of Multi-Band SWeep…
Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Mic…
2021
We have shown that prebiotic xylo-oligosaccharides (XOS) increased beneficial gut microbiota (GM) and prevented high fat diet-induced hepatic steatosis, but the mechanisms associated with these effects are not clear. We studied whether XOS affects adipose tissue inflammation and insulin signaling, and whether the GM and fecal metabolome explain associated patterns. XOS was supplemented or not with high (HFD) or low (LFD) fat diet for 12 weeks in male Wistar rats (n = 10/group). Previously analyzed GM and fecal metabolites were biclustered to reduce data dimensionality and identify interpretable groups of co-occurring genera and metabolites. Based on our findings, biclustering provides a use…
Prenatal exposure to perfluoroalkyl substances and birth outcomes in a Spanish birth cohort
2017
BACKGROUND: Prenatal perfluorooctanoate (PFOA) exposure has been associated with reduced birth weight but maternal glomerular filtration rate (GFR) may attenuate this association. Further, this association remains unclear for other perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA). We estimated associations between prenatal PFAS exposure and birth outcomes, and the influence of GFR, in a Spanish birth cohort. METHODS: We measured PFHxS, PFOS, PFOA, and PFNA in 1st-trimester maternal plasma (years: 2003-2008) in 1202 mother-child pairs. Continuous birth outcomes included standardized weight, length, he…
Maternal Iodine Status During Pregnancy Is Not Consistently Associated with Attention-Deficit Hyperactivity Disorder or Autistic Traits in Children
2020
Background: Severe iodine deficiency during pregnancy can cause intellectual disability, presumably through inadequate placental transfer of maternal thyroid hormone to the fetus. The association between mild-to-moderate iodine deficiency and child neurodevelopmental problems is not well understood. Objectives: We investigated the association of maternal iodine status during pregnancy with child attention-deficit hyperactivity disorder (ADHD) and autistic traits. Methods: This was a collaborative study of 3 population-based birth cohorts: Generation R (n = 1634), INfancia y Medio Ambiente (n = 1293), and the Avon Longitudinal Study of Parents and Children (n = 2619). Exclusion criteria were…
Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data
2019
Abstract Context Although the consequences of severe iodine deficiency are beyond doubt, the effects of mild to moderate iodine deficiency in pregnancy on child neurodevelopment are less well established. Objective To study the association between maternal iodine status during pregnancy and child IQ and identify vulnerable time windows of exposure to suboptimal iodine availability. Design Meta-analysis of individual participant data from three prospective population-based birth cohorts: Generation R (Netherlands), INMA (Spain), and ALSPAC (United Kingdom); pregnant women were enrolled between 2002 and 2006, 2003 and 2008, and 1990 and 1992, respectively. Setting General community. Participa…
Irradiation of the head reduces adult hippocampal neurogenesis and impairs spatial memory, but leaves overall health intact in rats.
2021
Treatment of brain cancer, glioma, can cause cognitive impairment as a side‐effect, possibly because it disrupts the integrity of the hippocampus, a structure vital for normal memory. Radiotherapy is commonly used to treat glioma, but the effects of irradiation on the brain are still poorly understood, and other biological effects have not been extensively studied. Here we exposed healthy adult male rats to small and moderate‐dose irradiation of the head. We found no effect of irradiation on systemic inflammation, weight gain or gut microbiota diversity, although it increased the abundance of Bacteroidaceae family, namely Bacteroides genus in the gut microbiota. Irradiation had no effect on…
A Simple Indicator Based Evolutionary Algorithm for Set-Based Minmax Robustness
2018
For multiobjective optimization problems with uncertain parameters in the objective functions, different variants of minmax robustness concepts have been defined in the literature. The idea of minmax robustness is to optimize in the worst case such that the solutions have the best objective function values even when the worst case happens. However, the computation of the minmax robust Pareto optimal solutions remains challenging. This paper proposes a simple indicator based evolutionary algorithm for robustness (SIBEA-R) to address this challenge by computing a set of non-dominated set-based minmax robust solutions. In SIBEA-R, we consider the set of objective function values in the worst c…
Les biens publics de la Méditerrannée
2007
Converencia de José Vidal-Beneyto en la "IX Asamblea de la Comunidad de las Universidades del Mediterráneo (CUM)" y con motivo también de la entrega del Premio del Mediterráneo 2003 al propio autor. Bari, Italia, 20-22 de noviembre de 2003. El texto no fue publicado hasta el año 2007.
Nueva Propuesta Museográfica del Museo Fallero de Valencia
2011
El objetivo de dicho Trabajo Fin de Máster es remarcar las deficiencias de la actual propuesta museográfica del Museo. Las Fallas contribuye al desarrollo de la ciudad y de todos los agentes que realizan la mejora y el crecimiento de la propia realidad de la urbe. Hay que tener en cuenta las capacidades, recursos y posiciones alcanzadas que limitan las posibilidades de aprovechar las oportunidades, por lo que hay que intentar evitarlas o paliarlas. En el caso de las Fallas las posibles debilidades son la falta de una protección adecuada para el Museo Fallero, institución que conserva el Arte Efímero y que debería tener el estatus de Museo para poder recibir una serie de subvenciones para su…