Search results for "INR"
showing 10 items of 184 documents
Canakinumab in systemic juvenile idiopathic arthritis: real-world data from a retrospective Italian cohort
2021
Abstract Objective The objective of this study was to use real-world data to evaluate the effectiveness and safety of canakinumab in Italian patients with systemic JIA (sJIA). Methods A retrospective multicentre study of children with sJIA was performed. Clinical features, laboratory parameters and adverse events were collected at baseline, and 6 and 12 months after starting canakinumab. The primary outcome measure of effectiveness was clinically inactive disease (CID) off glucocorticoids (GCs) treatment at 6 months. Results A total of 80 children from 15 Italian centres were analysed. Of the 12 patients who started canakinumab in CID while receiving anakinra, all maintained CID. Of the 68 …
A Snapshot on the On-Label and Off-Label Use of the Interleukin-1 Inhibitors in Italy among Rheumatologists and Pediatric Rheumatologists: A Nationwi…
2016
Background: Interleukin (IL)-1 inhibitors have been suggested as possible therapeutic options in a large number of old and new clinical entities characterized by an IL-1 driven pathogenesis. Objectives: To perform a nationwide snapshot of the on-label and off-label use of anakinra (ANA) and canakinumab (CAN) for different conditions both in children and adults. Methods: We retrospectively collected demographic, clinical, and therapeutic data from both adult and pediatric patients treated with IL-1 inhibitors from January 2008 to July 2016. Results: Five hundred and twenty-six treatment courses given to 475 patients (195 males, 280 females; 111 children and 364 adults) were evaluated. ANA wa…
2020
The biological anakinra appears promising to halt cytokine storm syndrome seen in severe courses of COVID-19. However, immunosuppression with anakinra may facilitate sepsis, necessitating continuous screening for bacterial superinfections.
Mitä opettaa ja miten? : musiikin opetussuunnitelmaa rakentamassa esikouluopettajien koulutukseen Swazimaassa
2014
Tutkielma käsittelee musiikin opetussuunnitelman tekoprosessia ja toteuttamista esikouluopettajille itselle vieraassa kulttuurissa yhteistyössä paikallisten ihmisten kanssa. Tutkimuksen tavoitteena oli suunnitella mahdollisimman hyvin maan koulutuksen tarpeita vastaava musiikinkurssi esikouluopettajia ympäri Swazimaata kouluttavalle EduGate-projektille selvittämällä millaisia asioita musiikista Swazimaalaisille esikouluopettajille olisi hyödyllistä opettaa. Käytin lähtökohtana suomalaisen varhaismusiikkikasvatuksen opsin tavoitteita ja sisältöjä, joista muokkasin opiskelijoille teetetyn kyselyn, koulutuksen järjestäjien toiveiden, Swazimaasta keräämäni informaation ja omien näkemysteni peru…
Kansallismielisyys, 'kulttuuri' ja keisarillinen Saksa : kansallisvaltion ja sen hallinnon 'kulttuuriin' perustuva legitimointi Heinrich v. Treitschk…
2003
Anwendungsbezogene Transformationen antiker Literatur im Neuhumanismus und in unmittelbarer Zeitgegenwart. Ausstellungspraktische und jugenddidaktisc…
2017
Właśnie w czasach oszczędności finansowych oraz postępującego procesu ekonomizacji kultury jest ważnym fakt, aby filolodzy angażowali się również kulturowo i politycznie dla swoich autorów, nad którymi sprawują opiekę naukową, oraz w zakresie tematyki dzieł. Artykuł opisuje przygotowywaną wystawę w Domu Literatury im. Johann-Heinrich-Voß'a w Penzlin, w miejscowości, w której Voß otrzymał pierwsze impulsy rozwoju. Voß wyjaśnia propozycje szkolno-pedagogiczne, w pewnym sensie skromne warsztaty literackie, które zostaną zrealizowane w ramach wystawy stałej zatytułowanej "Johann Heinrich Voß. Grek z Mecklenburii".
Penning-trap mass measurements on 92, 94-98, 100Mo with JYFLTRAP
2012
Penning-trap measurements on stable 92, 94-98, 100Mo isotopes have been performed with relative accuracy of \ensuremath1⋅10−8\ensuremath1⋅10−8 with the JYFLTRAP Penning-trap mass spectrometer by using 85Rb as a reference. The Mo isotopes have been found to be about 3keV more bound than given in the Atomic Mass Evaluation 2003 (AME03). The results confirm that the discrepancy between the ISOLTRAP and JYFLTRAP data for 101-105Cd isotopes was due to an erroneous value in the AME03 for 96Mo used as a reference at JYFLTRAP. The measured frequency ratios of Mo isotopes have been used to update mass-excess values of 30 neutron-deficient nuclides measured at JYFLTRAP. peerReviewed
Mass measurements of neutron-deficient nuclei and their implications for astrophysics
2012
During the years 2005-2010 the double-Penning-trap mass spectrometer JYFLTRAP has been used to measure the masses of 90 ground and 8 isomeric states of neutron-deficient nuclides with a typical precision of better than 10keV. The masses of 14 nuclides -- 84Zr , 88, 89Tc , 90-92Ru , 92-94Rh , 94, 95Pd , 106, 108, 110Sb -- have been experimentally determined for the first time. This article gives an overview on these measurements and their impact on the modeling of the astrophysical rp -process. peerReviewed
Underground multi-muon experiment EMMA
2011
EMMA is a new experiment designed for cosmic-ray composition studies around the knee energy operating at the shallow depth underground in the Pyhäsalmi mine, Finland. The array has sufficient coverage and resolution to determine the multiplicity, the lateral density distribution and the arrival direction of high-energy muons on an event by event basis. Preliminary results on the muon multiplicity extracted using one detector station of the array are presented. peerReviewed
Precise Determination of the Unperturbed 8B Neutrino Spectrum
2012
The measurement was performed at the Kernfysisch Versneller Instituut (KVI) at the University of Groningen, The Netherlands.; A measurement of the final state distribution of the 8B $\beta$ decay, obtained by implanting a 8B beam in a double-sided silicon strip detector, is reported here. The present spectrum is consistent with a recent independent precise measurement performed by our collaboration at the IGISOL facility, Jyvâskylä [O. S. Kirsebom et al., Phys. Rev. C 83, 065802 (2011)]. It shows discrepancies with previously measured spectra, leading to differences in the derived neutrino spectrum. Thanks to a low detection threshold, the neutrino spectrum is for the first time directly ex…