Search results for "INR"
showing 10 items of 184 documents
A focus on selected perspectives of the NUMEN project
2022
Abstract The use of double charge exchange reactions is discussed in view of their application to extract information that may be helpful to determinate the nuclear matrix elements entering in the expression of neutrinoless double beta decay half-life. The strategy adopted in the experimental campaigns performed at INFN - Laboratori Nazionali del Sud and in the analysis methods within the NUMEN project is briefly described, emphasizing the advantages of the multi-channel approach to nuclear reaction data analysis. An overview on the research and development activities on the MAGNEX magnetic spectrometer is also given, with a focus on the chosen technological solutions for the focal plane de…
Audzināšanas ideāls un īstenība: raksti par lietišķu paidagoģiju
1928
Saturs: Ievadam 3 Par lietišķu un romantisku paidagoģiju 5 Audzinātāja jēdziens un būtība 25 Mūsu paidagoģiskā prakse Pestalocija mācību apgaismojumā 46 Paidagoģijā un politika 60 Audzināšanas zinātnes sākumi 83
Rosyjski korpus posiłkowy (auksyliarny) na służbie Augusta II w Rzeczypospolitej i Saksonii. Nowe spojrzenie na sasko-polsko-rosyjską współpracę poli…
2019
Polityczno-militarna współpraca sasko-polsko-rosyjska od początku wielkiej wojny północnej (1700–1721) nie układała się po myśli Augusta II, który ponosił klęski w starciach z wojskami Karola XII i po przegranej Piotra I pod Narwą w 1700 roku wziął na siebie główny ciężar wojny. Próbą wspomożenia armii saskiej Augusta II przez cara, który obawiał się zawarcia przez władcę sasko-polskiego separatystycznego pokoju z królem szwedzkim, i chciał także zaangażowania w konflikt Rzeczypospolitej, było zorganizowanie rosyjskiego korpusu posiłkowego (auksyliarnego), który z perspektywy czasu okazał się zabiegiem politycznym, a w mniejszym stopniu wojskowym. W zaprezentowanym artykule recenzyjnym prob…
When are researchers willing to share their data? - Impacts of values and uncertainty on open data in academia.
2020
PLOS ONE 15(7), e0234172 (2020). doi:10.1371/journal.pone.0234172
Latvijas ūdeņu vides pētījumi un aizsardzība: LU Bioloģijas fakultātes Bioloģijas sekcijas referātu tēžu krājums (Rīga, 2013. gada 18. februāris)
2013
Latvijas Universitātes 71. zinātniskās konferences Bioloģijas sekcijas sēde (Rīga, 2013. gada 18. februāris) veltīta Prof. Heinriha Skujas 120. dzimšanas dienai.
Zinātņu vēsture un muzeoloģija (Latvijas Universitātes Raksti, 818. sēj.)
2022
Choice of second-line disease-modifying antirheumatic drugs after failure of methotrexate therapy for rheumatoid arthritis: A decision tree for clini…
2009
Objective To survey rheumatologists' preferences for the choice of a second-line disease-modifying antirheumatic drug (DMARD) after inadequate response with methotrexate (MTX) therapy in rheumatoid arthritis (RA). Methods Thirty-six rheumatologists stated their preferences for RA treatment after inadequate response with MTX therapy (optimal dose at least 6 months). From the initial scenario, we derived 54 vignettes varying by rheumatoid factor or anti–cyclic citrullinated peptide antibody presence, swollen joint count, Disease Activity Score in 28 joints, and structural damage. Respondents stated their preference among 5 therapeutic options: MTX continuation, switch to another conventional …
THE USE OF INTERLEUKIN 1 RECEPTOR ANTAGONIST (ANAKINRA) IN KAWASAKI DISEASE: A RETROSPECTIVE CASES SERIES
2018
Introduction: Persistent fever and inflammation after infusion of 2g/kg of IVIG, the standard treatment of KD represents a high-risk situation for coronary aneurysms in Kawasaki disease. Identifying patients at risk for IVIG resistance is difficult outside the Asian population, and there remains a critical unmet need to identify an anti-inflammatory treatment that is efficacious in all KD patients. Recent evidence from studies in animals and humans suggest a critical role for interleukin-1 (IL-1) α and β in the pathogenesis of KD. Objectives: To identify the clinical characteristics, reasons for use and response to treatment with anakinra in a retrospective series of patients with Kawasaki …
New In-Depth Analytical Approach of the Porcine Seminal Plasma Proteome Reveals Potential Fertility Biomarkers
2018
A complete characterization of the proteome of seminal plasma (SP) is an essential step to understand how SP influences sperm function and fertility after artificial insemination (AI). The purpose of this study was to identify which among characterized proteins in boar SP were differently expressed among AI boars with significantly different fertility outcomes. A total of 872 SP proteins, 390 of them belonging specifically to Sus Scrofa taxonomy, were identified (Experiment 1) by using a novel proteomic approach that combined size exclusion chromatography and solid-phase extraction as prefractionation steps prior to Nano LC-ESI-MS/MS analysis. The SP proteomes of 26 boars showing significan…
Drug survival of anakinra and canakinumab in monogenic autoinflammatory diseases: observational study from the International AIDA Registry
2021
Abstract Objectives To investigate survival of IL-1 inhibitors in monogenic autoinflammatory disorders (mAID) through drug retention rate (DRR) and identify potential predictive factors of drug survival from a real-life perspective. Patients and methods Multicentre retrospective study analysing patients affected by the most common mAID treated with anakinra or canakinumab. Survival curves were analysed with the Kaplan-Meier method. Statistical analysis included a Cox-proportional hazard model to detect factors responsible for drug discontinuation. Results Seventy-eight patients for a total of 102 treatment regimens were enrolled. The mean treatment duration was 29.59 months. The estimated D…