Search results for "INTEGRITY"
showing 10 items of 134 documents
Excitability regulation in the dorsomedial prefrontal cortex during sustained instructed fear responses: a TMS-EEG study
2018
AbstractThreat detection is essential for protecting individuals from adverse situations, in which a network of amygdala, limbic regions and dorsomedial prefrontal cortex (dmPFC) regions are involved in fear processing. Excitability regulation in the dmPFC might be crucial for fear processing, while abnormal patterns could lead to mental illness. Notwithstanding, non-invasive paradigms to measure excitability regulation during fear processing in humans are missing. To address this challenge we adapted an approach for excitability characterization, combining electroencephalography (EEG) and transcranial magnetic stimulation (TMS) over the dmPFC during an instructed fear paradigm, to dynamica…
Use of Information from Clinical Trials for an Integrated Cancer Registry
1990
AbstractThe registry of childhood malignancies in the F.R.G. is a combination of a population-based and hospital-based cancer registry. A large amount of the collected data originates from multicenter clinical trials which are integrated into the documentation system of the cancer registry. The paper describes the information flow and the system of data storage which consists of a central database on a departmental system at the registry and of several coordinated peripheral databases on microcomputers at the trial centers. Practical experience shows an increased availability and validity of the data in the registry since the implementation of the system. Aspects of data integrity and secur…
Efficacy and safety of bempedoic acid for the treatment of hypercholesterolemia: A systematic review and meta-analysis
2020
Background Bempedoic acid is a first-in-class lipid-lowering drug recommended by guidelines for the treatment of hypercholesterolemia. Our objective was to estimate its average effect on plasma lipids in humans and its safety profile. Methods and findings We carried out a systematic review and meta-analysis of phase II and III randomized controlled trials on bempedoic acid (PROSPERO: CRD42019129687). PubMed (Medline), Scopus, Google Scholar, and Web of Science databases were searched, with no language restriction, from inception to 5 August 2019. We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,460]; control arm [n = 1,328]). Effect sizes for changes in lipids and high-…
Attacks Against the WAP WTLS Protocol
1999
The WAP WTLS protocol was designed to provide privacy, data integrity, and authentication for wireless terminals. The protocol is currently being fielded, and it is expected that the protocol will be contained in millions of devices in a few years.
Look for methods, not conclusions
2019
Qualunque sia l'esito effettivo di un'indagine su un caso di presunta manipolazione dei dati, ci sono alcuni principi fermi che sono sempre veri e alcuni errori che devono essere evitati.
Experimental assessment of the hydro-mechanical behaviour of a shale caprock during CO2 injection
2021
Abstract The presented experimental study focuses on the hydro-mechanical characterisation of a shale caprock (Opalinus Clay) in contact with carbon dioxide. The objective of this paper, consists in the evaluation of the material's sealing capacity in terms of entry-pressure, mechanical behaviour and sensitivity of the transport properties to chemo-mechanical effects induced by gaseous and liquid CO2 injection. Two types of Opalinus Clay core samples are tested; shaly and carbonate-rich. The sealing capacity has been evaluated on the shaly OPA according to the stepwise and the residual methods and compared to the results from mercury intrusion porosimetry. The obtained results and the diffe…
Meta-analysis of the correlation between serum uric acid level and carotid intima-media thickness
2021
Objective Recently, increasing epidemiological evidence has shown that there is a correlation between serum uric acid level (SUA) and carotid intima-media thickness (CIMT). This paper explored the relationship between them through meta-analysis. Methods PubMed, Cochrane Library, EMBASE, Web of Science and Google Scholar were searched to obtain literature. The keywords used to retrieve the literature were carotid intima thickness, intima-media thickness, carotid atherosclerosis, carotid stenosis, carotid artery, uric acid, blood uric acid, and hyperuricaemia. The retrieval time was from the establishment of the database through July 2020. Stata15.0 and RevMan5.3 software were used for stati…
The yeast mitogen-activated protein kinase Slt2 is involved in the cellular response to genotoxic stress
2012
Abstract Background The maintenance of genomic integrity is essential for cell viability. Complex signalling pathways (DNA integrity checkpoints) mediate the response to genotoxic stresses. Identifying new functions involved in the cellular response to DNA-damage is crucial. The Saccharomyces cerevisiae SLT2 gene encodes a member of the mitogen-activated protein kinase (MAPK) cascade whose main function is the maintenance of the cell wall integrity. However, different observations suggest that SLT2 may also have a role related to DNA metabolism. Results This work consisted in a comprehensive study to connect the Slt2 protein to genome integrity maintenance in response to genotoxic stresses.…
Promoting and Assessing Integrity in the Research Degree
2008
Although postgraduate research is increasingly supported through the formalisation of supervision and programs providing generic support, those programs have seldom addressed the intention, often stated by universities in their graduate profiles, that postgraduates should have integrity, and ethical values. What methodology is required – how will universities support students to cultivate such sensitivity, assess this, and fulfill the expectation? The paper provides evidence that quality statements including some aspect of integrity are used in many UK and Australian universities. The importance of integrity, or ethical behaviour more generally, in postgraduate degrees and in professional p…
The Reprocessed Proba-V Collection 2: Product Validation
2021
With the objective to improve data quality in terms of cloud detection, absolute radiometric calibration and atmospheric correction, the PRoject for On-Board Autonomy-Vegetation (PROBA-V) data archive (October 2013 - June 2020) will be reprocessed to Collection 2 (C2). The product validation is organized in three phases and focuses on the intercomparison with PROBA-V Collection 1 (C1), but also consistency analysis with SPOT-VGT, Sentinel-3 SYN-VGT, Terra-MODIS and METOP-AVHRR is foreseen. First preliminary results show the better performance of cloud and snow/ice masking, and indicate that statistical consistency between PROBA-V C2 and C1 are in line with expectations. PROBA-V C2 data are …