Search results for "INTEGRITY"

Assessment of ecosystem integrity and service gradients across Europe using the LTER Europe network

2015

Better integration of knowledge from ecological, social and economic science is necessary to advance the understanding and modelling of socio-ecological systems. To model ecosystem integrity (EI) and ecosystem services (ES) at the landscape scale, assessment matrices are commonly used. These matrices assign capacities to provide different services to different land cover types. We revised such an existing matrix and examined the regional heterogeneity in EI and ES provision in Europe and searched for spatial gradients in their provision to elucidate their suitability for large-scale EI and ES mapping in Europe. Overall, 28 sites belonging to the Long-Term Ecological Research network in Euro…

Front Cover: Filling the Gap in the Metallacrown Family: The 9‐MC‐3 Chromium Metallacrown (Chem. Eur. J. 13/2021)

2021

The effects of cryogenic cooling on surface integrity in hard machining: A comparison with dry machining

2012

The role of cell interactions in the control of RNA synthesis.

1967

Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions

2010

How DNA repair machineries detect and access, within the context of chromatin, lesions inducing little or no distortion of the DNA structure is a poorly understood process. Removal of oxidized bases is initiated by a DNA glycosylase that recognises and excises the damaged base, initiating the base excision repair (BER) pathway. We show that upon induction of 8-oxoguanine, a mutagenic product of guanine oxidation, the mammalian 8-oxoguanine DNA glycosylase OGG1 is recruited together with other proteins involved in BER to euchromatin regions rich in RNA and RNA polymerase II and completely excluded from heterochromatin. The underlying mechanism does not require direct interaction of the prote…

Nucleotide excision repair of abasic DNA lesions

2019

AbstractApurinic/apyrimidinic (AP) sites are a class of highly mutagenic and toxic DNA lesions arising in the genome from a number of exogenous and endogenous sources. Repair of AP lesions takes place predominantly by the base excision pathway (BER). However, among chemically heterogeneous AP lesions formed in DNA, some are resistant to the endonuclease APE1 and thus refractory to BER. Here, we employed two types of reporter constructs accommodating synthetic APE1-resistant AP lesions to investigate the auxiliary repair mechanisms in human cells. By combined analyses of recovery of the transcription rate and suppression of transcriptional mutagenesis at specifically positioned AP lesions, w…

Spatio-temporal Schema Integration with Validation: A Practical Approach

2005

We propose to enhance a schema integration process with a validation phase employing logic-based data models. In our methodology, we validate the source schemas against the data model; the inter-schema mappings are validated against the semantics of the data model and the syntax of the correspondence language. In this paper, we focus on how to employ a reasoning engine to validate spatio-temporal schemas and describe where the reasoning engine is plugged into our integration methodology. The validation phase distinguishes our integration methodology from other approaches. We shift the emphasis on automation from the a priori discovery to the a posteriori checking of the inter-schema mapping…

An Experimental Investigation of Residual Stresses in Hard Machining of AISI 52100 Steel

2011

In this paper an experimental investigation was conducted to determine the effects of the tool cutting-edge geometry, workpiece hardness, cutting speed, and microstructural changes (white and dark layers) on the residual stresses in dry orthogonal hard machining of AISI 52100 steel. X-ray diffraction technique was used to obtain in-depth residual stresses profiles in both axial and circumferential directions. The results show that tool geometry, workpiece hardness and cutting parameters significantly affect the surface residual stress, maximum compressive residual stress below the machined surface and its location. Moreover, microstructural analysis shows that thermally-induced phase transf…

Human Dignity and Legally Protected Goods in Criminal Law

2020

Criminal law protects certain basic goods because they are directly or indirectly connected with the dignity of the person. However, in cases such as euthanasia, prostitution or surrogacy motherhood, the appeal to the dignity of the person is used, in the opposite sense, as the basis for decriminalization. In these cases, dignity is identified with the autonomy of the person and their capacity to dispose of all their goods, even if they are essential. This work argues that there is an ontological core of dignity (requirement of absolute respect) that is subtracted from autonomy and that is protected by the concept of ‘moral integrity’. It prevents certain conducts from being decriminalized …

Erratum to “Hydrolytic enzyme activity of Paenibacillus sp. strain B2 and effects of the antagonistic bacterium on cell integrity of two soil-borne p…

2001

Ce texte contient des corrections apportées à l'article " Hydrolytic enzyme activity of Paenibacillus sp. strain B2 and effects of the antagonistic bacterium on cell integrity of two soil-borne pathogenic fungi" sorti dans le numéro 15 du journal "Applied Soil Ecology" sorti en 2000.