Search results for "INTESTINAL MICROBIOTA"
showing 6 items of 16 documents
High frequencies of antibiotic resistance genes in infants' meconium and early fecal samples
2016
The gastrointestinal tract (GIT) microbiota has been identified as an important reservoir of antibiotic resistance genes (ARGs) that can be horizontally transferred to pathogenic species. Maternal GIT microbes can be transmitted to the offspring, and recent work indicates that such transfer starts before birth. We have used culture-independent genetic screenings to explore whether ARGs are already present in the meconium accumulated in the GIT during fetal life and in feces of 1-week-old infants. We have analyzed resistance to β-lactam antibiotics (BLr) and tetracycline (Tcr), screening for a variety of genes conferring each. To evaluate whether ARGs could have been inherited by maternal tr…
Effect of a Prebiotic Formulation on Frailty Syndrome
2016
Aging can result in major changes in the composition and metabolic activities of bacterial populations in the gastrointestinal system and result in impaired function of the immune system. We assessed the efficacy of prebiotic Darmocare Pre (R) (Bonusan Besloten Vennootschap (BV), Numansdorp, The Netherlands) to evaluate whether the regular intake of this product can improve frailty criteria, functional status and response of the immune system in elderly people affected by the frailty syndrome. The study was a placebo-controlled, randomized, double blind design in sixty older participants aged 65 and over. The prebiotic product was composed of a mixture of inulin plus fructooligosaccharides …
The “unnatural” history of colorectal cancer in Lynch syndrome : lessons from colonoscopy surveillance
2021
Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alon…
Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: A potential role for bile acids
2017
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, yet the pathogenesis of NAFLD is only partially understood. Here, we investigated the role of the gut bacteria in NAFLD by stimulating the gut bacteria via feeding mice the fermentable dietary fiber, guar gum (GG), and suppressing the gut bacteria via chronic oral administration of antibiotics. GG feeding profoundly altered the gut microbiota composition, in parallel with reduced diet-induced obesity and improved glucose tolerance. Strikingly, despite reducing adipose tissue mass and inflammation, GG enhanced hepatic inflammation and fibrosis, concurrent with markedly elevated plasma and hepatic bile acid l…
Dietary polyphenols as antidiabetic agents: Advances and opportunities
2020
Abstract Dietary polyphenols have been widely investigated as antidiabetic agents in cell, animals, human study, and clinical trial. The number of publication (Indexed by Web of Science) on “polyphenols and diabetes” significantly increased since 2010. This review highlights the advances and opportunities of dietary polyphenols as antidiabetic agents. Dietary polyphenols prevent and manage Type 2 diabetes mellitus via the insulin‐dependent approaches, for instance, protection of pancreatic islet β‐cell, reduction of β‐cell apoptosis, promotion of β‐cell proliferation, attenuation of oxidative stress, activation of insulin signaling, and stimulation of pancreas to secrete insulin, as well as…
Cities and their effects on free-living and host-associated microbes
2023
Mikrobit ovat oleellisen tärkeitä elämälle maapallolla, ja niitä esiintyy vapaina ympäristössä tai isäntäorganismeissa tukien ekosysteemien ja/tai isäntien normaalia toimintaa. Ihminen vaikuttaa lähes kaikkiin planeettamme elinympäristöihin aiheuttaen niiden häviämistä ja huonontumista (mukaan lukien kaupunkien rakentaminen) sekä ympäristöjen saastumista ja ilmastonmuutosta. Mikrobiyhteisöjen (kutsutaan myös mikrobiotaksi, mukaan lukien bakteerit ja sienet) odotetaan reagoivan näihin ihmisen aiheuttamiin valintapaineisiin sopeutumalla muuttuvaan ympäristöön. Siten ihmisen aiheuttamat muutokset ympäristössä voivat muovata mikrobiyhteisöjä (sekä vapaasti eläviä että isäntiin liittyviä) muutta…