Search results for "IONT"
showing 10 items of 382 documents
Combination strategies for enhancing transdermal absorption of sumatriptan through skin
2006
The aim of the present work was to characterize in vitro sumatriptan transdermal absorption through human skin and to investigate the effect of chemical enhancers and iontophoresis applied both individually and in combination. A secondary objective was to compare the results obtained with those in porcine skin under the same conditions, in order to characterize the relationship between the two skin models and validate the porcine model for further research use. Transdermal flux of sumatriptan was determined in different situations: (a) after pre-treatment of human skin with ethanol, Azone (1-dodecyl-azacycloheptan-2-one), polyethylene glycol 600 and R-(+)-limonene, (b) under iontophoresis a…
Physical Methods for Enhancing Oral Mucosal Delivery: Sonophoresis, Iontophoresis and Electroporation
2015
The need for more rapid onset of action and improved absorption of medications has resulted in great development of drug delivery technologies. Transmucosal drug delivery offers a convenient route of administration for a variety of clinical indications. Unfortunately, the wide variability in structure of the oral mucosal tissues could constitute a key factor in drug penetration and absorption. To circumvent this obstacle and to increase the drug flux through the mucosal membranes, different approaches to permeation enhancement are used. This chapter describes the most significant aspects of the physical techniques widely used such as sonophoresis, iontophoresis, and electroporation. These p…
Transdermal and Skin-Targeted Drug Delivery
1997
Background: The application of therapeutic agents to the skin addresses three general objectives: (a) the treatment of a variety of dermatologic diseases; (b) the “targeted” delivery of drugs to deeper subcutaneous tissues, with a concomitant reduction in systemic exposure; and (c) socalled transdermal administration to elicit a systemic pharmacologic effect. Objective: Recently, significant progress towards all three goals has been recorded and the level of research and development activity remains high. We aim to discuss these advances from mechanistic and clinical standpoints. Results: For the topical treatment of skin disease, novel vehicles (e.g., stabilized, supersaturated systems and…
A performance study of LTE MIMO-OFDM systems using the extended one-ring MIMO channel model
2012
In this paper, we consider a long-term evolution (LTE) system for the downlink by using multiple-input multiple-output (MIMO) orthogonal frequency division multiplexing (OFDM) techniques. The downlink channel is modeled by the socalled extended MIMO one-ring model. This model extends the well-known narrowband one-ring model with respect to frequency selectivity. The symbol error rate (SER) performance of the LTE MIMO-OFDM system is investigated for the downlink by employing different kinds of spatial encoders, where it is assumed that the channel state information (CSI) is perfectly known. For comparison, the space-time block coding (STBC) scheme, the vertical Bell Laboratories layered spac…
A limited feedback scheme based on spatially correlated channels for coordinated multipoint systems
2012
High spectral efficiency can be achieved in the downlink of multi-antenna coordinated multi-point systems provided that the multiuser interference is appropriately managed at the transmitter side. For this sake, downlink channel information needs to be sent back by the users, thus reducing the rate available at the uplink channel. The amount and type of feedback information required has been extensively studied and many limited feedback schemes have been proposed lately. A common pattern to all of them is that achieving low rates of feedback information is possible at the cost of increasing complexity at the user side and, sometimes, assuming that some statistics of the channel are known. I…
The influence of severity of fading on the statistical properties of the capacity of Nakagami-m channels with MRC and EGC
2010
In this article, we have studied the statistical properties of the capacity of Nakagami-m channels when spatial diversity combining, such as maximal ratio combining (MRC) and equal gain combining (EGC), is employed at the receiver. The presented results provide insight into the statistical properties of the channel capacity under a wide range of fading conditions in wireless links using L-branch diversity combining techniques. We have derived closed-form analytical expressions for the probability density function (PDF), cumulative distribution function (CDF), level-crossing rate (LCR), and average duration of fades (ADF) of the channel capacity. The statistical properties of the capacity ar…
Reducing complexity in H.264/AVC motion estimation by using a GPU
2011
H.264/AVC applies a complex mode decision technique that has high computational complexity in order to reduce the temporal redundancies of video sequences. Several algorithms have been proposed in the literature in recent years with the aim of accelerating this part of the encoding process. Recently, with the emergence of many-core processors or accelerators, a new approach can be adopted for reducing the complexity of the H.264/AVC encoding algorithm. This paper focuses on reducing the inter prediction complexity adopted in H.264/AVC and proposes a GPU-based implementation using CUDA. Experimental results show that the proposed approach reduces the complexity by as much as 99% (100x of spe…
Periodic Orthogonal Wavelets and Wavelet Packets
2018
In this chapter, we discuss how to derive versatile families of periodic discrete-time orthogonal wavelets and wavelet packets from discrete and discrete-time splines outlined in Chap. 3. These wavelets and wavelet packets, although not having compact supports, are well localized in the time domain. They can have any number of discrete vanishing moments. Their DFT spectra tend to have a rectangular shape when the spline order grows and provide a collection of refined splits of the Nyquist frequency band. The wavelet and wavelet packet transforms are implemented in a fast way using the FFT.
Discrete-Time Periodic Wavelet Packets
2014
Direct and inverse wavelet and wavelet packet transforms of a spline are implemented by filtering the spline’s coordinates by two-channel critically sampled p-filter banks. In this chapter, those p-filter banks are utilized for processing discrete-time signals. The p-filter banks generate discrete-time wavelets and wavelet packets in the spaces of 1D and 2D periodic signals.
State Estimation of a Nonlinear Unmanned Aerial Vehicle Model using an Extended Kalman Filter
2008
An Extended Kalman Filter is designed in order to estimate both state variables and wind velocity vector at the same time for a non conventional unmanned aircraft. The proposed observer uses few measurements, obtained by means of either conventional simple air data sensors or a low cost GPS. To cope with the low rate of the GPS with respect to the other sensors, the EKF algorithm has been modified to allow for a dual rate measurement model. State propagation is obtained by means of an accurate six degrees of freedom nonlinear model of the aircraft dynamics. To obtain joint estimation of state and disturbance, wind velocity components are included in the set of the state variables. Both stoc…