Search results for "IP3R"
showing 3 items of 3 documents
Redox signaling in acute pancreatitis
2015
Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…
Taste receptors signalling
2010
International audience
Piecing together the taste signaling puzzle
2010
International audience; The identification of the genes coding for bitter, umami, sweet and sour taste receptors has provided us with unique tools to investigate the gustatory system. As a consequence, tremendous progress towards our understanding of the functional organization of the peripheral taste system has been achieved over the past decade. In particular, key components of the taste receptors signaling cascades have been identified as well as populations of chemosensory cells in the olfactory, respiratory and digestive systems expressing taste receptors. Besides sharing receptors and signaling molecules (gustducin, phospholipase-C b2…) with taste bud cells, these cells display a simi…