Search results for "IPM"
showing 10 items of 1361 documents
Biases in study design, implementation, and data analysis that distort the appraisal of clinical benefit and ESMO-Magnitude of Clinical Benefit Scale…
2021
BACKGROUND: The European Society for Medical Oncology-Magnitude of Clinical Benefit Scale (ESMO-MCBS) is a validated, widely used tool developed to score the clinical benefit from cancer medicines reported in clinical trials. ESMO-MCBS scores assume valid research methodologies and quality trial implementation. Studies incorporating flawed design, implementation, or data analysis may generate outcomes that exaggerate true benefit and are not generalisable. Failure to either indicate or penalise studies with bias undermines the intention and diminishes the integrity of ESMO-MCBS scores. This review aimed to evaluate the adequacy of the ESMO-MCBS to address bias generated by flawed design, im…
Shaping inter-firm collaboration in new product development in the automobile industry: A trade-off between a transaction and relational-based approa…
2008
Abstract Shaping collaboration in the new product development (NPD) has always been a very difficult task, especially in complex industries like the automobile one. This complexity is particularly true during the engineering phase of the NPD process, where different complex systems are to be designed in a collaborative way. Basically, two-kind of approaches have been observed in the literature and industry: one is more related to market transactions, specifically the west car-company style, the other is more relational based, as in the Japanese car-company style. Now, the increasing globalisation of the industry asks for a merge of the two approaches; indeed, the increasing use of standard …
Magnetization of3He spin filter cells
2007
A number of valved quartz glass 3He spin filter cells have been repeatedly exposed to various external magnetic fields in order to determine the influence of induced wall magnetization on the relaxation time in the cells. The procedures of magnetizing and degaussing of cells are described. A comparison of T1 measurements performed in the same cell by different methods attest the good reliability of the measurements as well as the time stability of T1 in Cs-coated quartz glass cells. No orientation dependence of the relaxation in fields of 8 G was observed. A strong dependence of T1 on the strengths of external magnetic fields, applied perpendicular to the direction of the guide field used d…
Presenting signs and patient co-variables in Gaucher disease: outcome of the Gaucher Earlier Diagnosis Consensus (GED-C) Delphi initiative.
2019
Background: Gaucher disease (GD) presents with a range of signs and symptoms. Physicians can fail to recognise the early stages of GD owing to a lack of disease awareness, which can lead to significant diagnostic delays and sometimes irreversible but avoidable morbidities. Aim: The Gaucher Earlier Diagnosis Consensus (GED-C) initiative aimed to identify signs and co-variables considered most indicative of early type 1 and type 3 GD, to help non-specialists identify ‘at-risk’ patients who may benefit from diagnostic testing. Methods: An anonymous, three-round Delphi consensus process was deployed among a global panel of 22 specialists in GD (median experience 17.5 years, collectively managin…
N2O emission in maize-crops fertilized with pig slurry, matured pig manure or ammonium nitrate in Brittany
2008
International audience; N2O is a potent greenhouse gas and solutions have to be sought to reduce its emission from agriculture. This work evaluates N2O emission from maize-crop (Zea mays) fields submitted to different organic or mineral fertilizers (pig slurry, matured pig manure or ammonium nitrate) in Brittany (France). N2O emission was evaluated along a year in two experimental sites receiving 110 or 180 kg N ha−1 as ammonium nitrate or pig slurry and 180 or 132 kg N ha−1 as ammonium nitrate or matured pig manure at Champ Noel and Le Rheu experimental plots, respectively. N2O emission was evaluated by interpolation method of periodic fluxes on the field scale and by simulation with NOE a…
Tooth-implant connection in removable denture.
2016
When the patient cannot be rehabilitated with a fixed denture, or when he does not succeed in adapting to a traditional removable denture, a possible alternative solution consists in the use of a limited number of implants, placed in strategic positions in the arches of the patient, and subsequently connected to their residual teeth. The aim of this review is to evaluate the progress made on connections between teeth and implants in removable denture, to analyze their advantages and disadvantages and to compare the survival rate, both of the teeth and of the implants used as abutments, present in the various studies taken into examination, with the aim of being able to evaluate the effectiv…
Cutting efficiency of heat-treated nickel-titanium single-file systems at different incidence angles.
2020
Cutting efficiency of Reciproc R25 (REC) and Reciproc blue R25 (REB) at different inclinations was evaluated. Sixty new files were tested at 90°, 70° and 45° of inclination in relation to the sample (n = 10), using a customised machine. All files were activated in reciprocation against standardised gypsum blocks for 120 s. Cutting efficiency was determined by measuring the block weight loss with an analytical balance and measuring the length of the block surface cut using a digital calliper. Data were statistically analysed (two-way ANOVA, Bonferroni t-test) with the significance level set at P < 0.05. There was no difference for REC among the tested angles. REB had no statistical differenc…
Length of endodontic files measured in digital radiographs with and without noise-suppression filters: an ex-vivo study
2011
The aim of this study is to evaluate if theoretically possible edge shifts induced by noise-suppression filters potentially occur on objects found in digital radiographs. Most manufacturers carry out noise-suppression filtering of their images before they are displayed to the user. It is not usually possible for the user to disrupt the function of the filters. The use of these filters can lead to deletion of small image structures.K-files (ISO size 06, 08, 10 and 15) were placed in the root canals of 6 human teeth located in cadaver jaw segments. File tip positions were measured on original and filtered digital images by three observers. The file position was marked on each filtered image a…
Electrochemical corrosion assessment of RaCe and Mtwo rotary nickle-titanium instruments after clinical use and sterilization
2010
Aim: The aim of the present study was to electrochemically evaluate corrosion resistance of RaCe and Mtwo files after repeated sterilization and preparation procedures. Study Design: A total of 450 rotary files were used. In the working groups, 72 files from each file type were distributed into 4 groups. RaCe and Mtwo files were used to prepare one root canal of the mesial root of extracted human mandibular first molars. The procedure was repeated to prepare 2 to 8 canals. The following irrigation solutions were used: group 1, RaCe files with 2.5% NaOCl; group 2, RaCe files with normal saline; group 3, Mtwo files with 2.5% NaOCl; and group 4, Mtwo files with normal saline in the manner desc…
In vitro comparison of the retention capacity of new aesthetic brackets.
1999
Tensile bond strength and bond failure location were evaluated in vitro for two types of aesthetic brackets (non-silanated ceramic, polycarbonate) and one stainless steel bracket, using bovine teeth as the substrate and diacrylate resin as the adhesive. The results show that metallic bracket had the highest bond strength (13.21 N) followed by the new plastic bracket (12.01 N), which does not require the use of a primer. The non-silanated ceramic bracket produced the lowest bond strength (8.88 N). Bond failures occurred mainly between bracket and cement, although a small percentage occurred between the enamel-cement interface with the metal and plastic brackets and within the cement for the …